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Inf2 Gene Detail
Summary
  • Symbol
    Inf2
  • Name
    inverted formin, FH2 and WH2 domain containing
  • Synonyms
    2610204M08Rik, EG629699
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917685
    NCBI Gene: 70435
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:112555218-112581991 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 61.20 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    359 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917685
protein coding gene Chr12:112555121-112581991 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020153
protein coding gene Chr12:115045801-115072119 (+)
A/J MGP_AJ_G0020109
protein coding gene Chr12:110616787-110644692 (+)
AKR/J MGP_AKRJ_G0020084
protein coding gene Chr12:113806363-113834314 (+)
BALB/cJ MGP_BALBcJ_G0020094
protein coding gene Chr12:111061535-111087808 (+)
C3H/HeJ MGP_C3HHeJ_G0019896
protein coding gene Chr12:114312064-114339373 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020539
protein coding gene Chr12:118607290-118639636 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018152
protein coding gene Chr12:107048423-107075494 (+)
CAST/EiJ MGP_CASTEiJ_G0019436
protein coding gene Chr12:109157905-109185888 (+)
CBA/J MGP_CBAJ_G0019863
protein coding gene Chr12:123141395-123170152 (+)
DBA/2J MGP_DBA2J_G0019980
protein coding gene Chr12:110096898-110123472 (+)
FVB/NJ MGP_FVBNJ_G0019965
protein coding gene Chr12:108919970-108946807 (+)
LP/J MGP_LPJ_G0020054
protein coding gene Chr12:114872145-114898371 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020003
protein coding gene Chr12:126232025-126258455 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020568
protein coding gene Chr12:113329239-113357194 (+)
PWK/PhJ MGP_PWKPhJ_G0019198
protein coding gene Chr12:104754178-104781082 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019001
protein coding gene Chr12:107485156-107514342 (+)
WSB/EiJ MGP_WSBEiJ_G0019496
protein coding gene Chr12:114236286-114264807 (+)



Homology
more
  • Human Ortholog
    INF2, inverted formin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INF2, inverted formin 2
  • Synonyms
    C14orf151, C14orf173, CMTDIE, FSGS5, pp9484
  • Links
    NCBI Gene ID: 64423
    neXtProt AC: NX_Q27J81
    UniProt: Q27J81

  • Chr Location
    14q32.33; chr14:104681146-104722535 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human INF2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display placental vasculopathy, restricted fetal growth, increased gestational length and transient increase in maternal blood pressure in the late stages of pregnancy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037679 Ensembl Gene Model | MGI Sequence Detail 26774 C57BL/6J ±  kb
    transcript ENSMUST00000101029 Ensembl | MGI Sequence Detail 4001 Not Applicable  
    polypeptide ENSMUSP00000098591 Ensembl | MGI Sequence Detail 1271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 52
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144743, MGI:2145010, MGI:3647580
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:338401 Nutter CA, et al., Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1. Brain. 2023 May 5;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory