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Inf2 Gene Detail
Summary
  • Symbol
    Inf2
  • Name
    inverted formin, FH2 and WH2 domain containing
  • Synonyms
    2610204M08Rik, EG629699
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917685
    NCBI Gene: 70435
  • Gene Overview
    MyGene.info: INF2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:112588784-112615557 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26774 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 61.20 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    INF2, inverted formin, FH2 and WH2 domain containing
  • Vertebrate Orthologs
    8
  • Human Ortholog
    INF2, inverted formin, FH2 and WH2 domain containing
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C14orf151, C14orf173, CMTDIE, FSGS5, pp9484
  • Links
    NCBI Gene ID: 64423
    neXtProt AC: NX_Q27J81
    UniProt: Q27J81

  • Chr Location
    14q32.33; chr14:104689606-104719610 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human INF2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display placental vasculopathy, restricted fetal growth, increased gestational length and transient increase in maternal blood pressure in the late stages of pregnancy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037679 Ensembl Gene Model | MGI Sequence Detail 26774 C57BL/6J ±  kb
    transcript ENSMUST00000101029 Ensembl | MGI Sequence Detail 4001 Not Applicable  
    polypeptide ENSMUSP00000098591 Ensembl | MGI Sequence Detail 1271 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      363 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 51
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144743, MGI:2145010, MGI:3647580
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:255715 Lamm KYB, et al., Inverted formin 2 regulates intracellular trafficking, placentation, and pregnancy outcome. Elife. 2018 Jan 8;7(None):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory