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Inf2
Gene Detail
Symbol

Name
ID
Inf2
inverted formin, FH2 and WH2 domain containing
MGI:1917685
Synonyms
2610204M08Rik, EG629699
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.20 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:112588784-112615556 bp, + strand
From Ensembl annotation of GRCm38

  26773 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:82406  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: INF2
Gene Tree: Inf2

Human
homologs
INF2, inverted formin, FH2 and WH2 domain containing
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 64423
neXtProt AC: NX_Q27J81

Human Synonyms: C14orf151, C14orf173, CMTDIE, FSGS5, pp9484

Human Chr (Location): 14q32.33; chr14:104689606-104719610 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human INF2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Inf2 interacts with 92 markers (Mir17, Mir20b, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process actin cytoskeleton organization, cellular component organization, ...
Component cytoplasm, endoplasmic reticulum, ...
Function actin binding, Rho GTPase binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (3)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 30
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000037679 (Evidence)
Entrez Gene 70435 (Evidence)
UniGene 250193
DFCI TC1581708, TC1585923, TC1706605
DoTS DT.101375005, DT.487839, DT.99854716
NIA Mouse Gene Index U014450
Consensus CDS Project CCDS36571.1
International Mouse Phenotyping Consortium Status Inf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037679 Ensembl Gene Model | MGI Sequence Detail 26773 C57BL/6J ±  kb
transcript ENSMUST00000101029 Ensembl | MGI Sequence Detail 4600 Not Applicable 
polypeptide ENSMUSP00000098591 Ensembl | MGI Sequence Detail 1271 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(359 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015425 Actin-binding FH2
InterPro IPR016024 Armadillo-type fold
InterPro IPR010472 Diaphanous FH3
InterPro IPR010473 Diaphanous GTPase-binding
InterPro IPR014768 GTPase-binding/formin homology 3
InterPro IPR003124 WH2 domain
Protein Ontology PR:000009032 inverted formin-2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193484 Korobova F, et al., An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science. 2013 Jan 25;339(6118):464-7
All references(35)
Other
accession IDs
MGI:2144743, MGI:2145010, MGI:3647580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory