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Tspan15 Gene Detail
Summary
  • Symbol
    Tspan15
  • Name
    tetraspanin 15
  • Synonyms
    2700063A19Rik, Tm4sf15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917673
    NCBI Gene: 70423
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:62021175-62067030 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 32.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1563 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917673
 protein coding gene Chr10:62021175-62067055 (-)
129S1/SvImJ ENSMUSG00200025365
 protein coding gene Chr10:58693401-58739686 (-)
A/J ENSMUSG00195026592
 protein coding gene Chr10:59000726-59047006 (-)
AKR/J ENSMUSG00220036358
 protein coding gene Chr10:58694026-58740313 (-)
BALB/cJ ENSMUSG00180022295
 protein coding gene Chr10:59043009-59089288 (-)
C3H/HeJ ENSMUSG00175023477
 protein coding gene Chr10:58900656-58946935 (-)
C57BL/6NJ ENSMUSG00215016898
 protein coding gene Chr10:58641120-58687403 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015379
 protein coding gene Chr10:56693295-56736714 (-)
CAST/EiJ ENSTCUG00005027422
 protein coding gene Chr10:58693909-58740273 (-)
CBA/J ENSMUSG00210036017
 protein coding gene Chr10:58778953-58825230 (-)
DBA/2J ENSMUSG00185041047
 protein coding gene Chr10:59120510-59166770 (-)
FVB/NJ ENSMUSG00205022658
 protein coding gene Chr10:58794053-58840322 (-)
JF1/MsJ ENSUMUG00000011085
 protein coding gene Chr10:60357352-60403772 (-)
LP/J ENSMUSG00230017542
 protein coding gene Chr10:60923495-60969771 (-)
NOD/ShiLtJ ENSMUSG00190029870
 protein coding gene Chr10:59106131-59152400 (-)
NZO/HlLtJ ENSMUSG00225044981
 protein coding gene Chr10:65204469-65250740 (-)
PWK/PhJ ENSLUMG00010020792
 protein coding gene Chr10:58727004-58773410 (-)
SPRET/EiJ ENSMSPG00010022846
 protein coding gene Chr10:60316440-60358990 (-)
WSB/EiJ ENSIUOG00005037063
 protein coding gene Chr10:58676626-58722327 (-)



Homology
more
  • Human Ortholog
    TSPAN15, tetraspanin 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN15, tetraspanin 15
  • Synonyms
    2700063A19Rik, NET-7, NET7, TM4SF15
  • Links
    NCBI Gene ID: 23555
    UniProt: O95858

  • Chr Location
    10q22.1; chr10:69451150-69549508 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit a slight increase in mortality within the first 3 weeks of birth. No overt neurological symptoms or hippocampal synapse abnormalities are seen. A different knock-out allele showed incomplete preweaning lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    4
  • cDNA Data
    45
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037031 Ensembl Gene Model | MGI Sequence Detail 45856 C57BL/6J ±  kb
    transcript ENSMUST00000047883 Ensembl | MGI Sequence Detail 3638 Not Applicable  
    polypeptide ENSMUSP00000047029 Ensembl | MGI Sequence Detail 294 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 45
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915962, MGI:2143799
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:387130 Yea JH, et al., Signaling and transcriptional networks governing late synovial joint development. Dev Biol. 2026 Sep;537:28-38
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory