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Cox10 Gene Detail
Summary
  • Symbol
    Cox10
  • Name
    cytochrome c oxidase assembly protein 10
  • Synonyms
    2410004F01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917633
    NCBI Gene: 70383
Location & Maps
more
  • Sequence Map
    Chr11:63962627-64079468 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      116842 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    COX10, COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    COX10, COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 1352
    neXtProt AC: NX_Q12887

  • Chr Location
    17p12; chr17:14069402-14217922 (+)  GRCh38.p2

Human Diseases
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  • Diseases
    2 with Cox10 mouse models; 2 with human COX10 associations

Human Disease Mouse Models
       Mitochondrial Complex IV Deficiency   OMIM: 220110 View 1 model
       Mitochondrial Myopathy   OMIM: 251900 View 1 model
       Leigh Syndrome; LS   OMIM: 256000
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    2
  • Genomic Mutations
    1 involving Cox10
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005891 VEGA Gene Model | MGI Sequence Detail 116842 C57BL/6J ±  kb
transcript OTTMUST00000013112 VEGA | MGI Sequence Detail 2915 Not Applicable  
polypeptide OTTMUSP00000006085 VEGA | MGI Sequence Detail 443 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    890 from dbSNP Build 137
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005769 protoheme IX farnesyltransferase, mitochondrial
  • EC
  • InterPro Domains
    IPR006369 Protohaem IX farnesyltransferase
    IPR016315 Protohaem IX farnesyltransferase, mitochondria
    IPR030470 UbiA prenyltransferase conserved site
    IPR000537 UbiA prenyltransferase family
Molecular
Reagents
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  • All nucleic 45
    cDNA 43
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGI:2144433
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:188773 Diaz F, et al., A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions. Hum Mol Genet. 2012 Dec 1;21(23):5066-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory