Cox10
Gene Detail

Symbol Name ID

Cox10 cytochrome c oxidase assembly protein 10 MGI:1917633

Synonyms

2410004F01Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

39.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:63962627-64079468 bp, - strand From VEGA annotation of GRCm38   116842 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:80170  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protoheme IX farnesyltransferase, mitochondrial type
Gene Tree: Cox10

Human homologs

Human Homolog		COX10, cytochrome c oxidase assembly homolog 10 (yeast)
NCBI Gene ID		1352
neXtProt AC		NX_Q12887
Human Chr (Location)		17p12; chr17:13972719-14111996 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
Human Diseases Modeled Using Mouse Cox10 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	aerobic respiration, cellular respiration, ...
Component	integral to membrane, membrane, ...
Function	cytochrome-c oxidase activity, farnesyltranstransferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (108)    Tissues (97)    Images (17)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	108

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) cDNA(43) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005891 (Evidence)
Ensembl Gene Model	ENSMUSG00000042148 (Evidence)
Entrez Gene	70383 (Evidence)
UniGene	340211
DFCI	TC1575820, TC1610514
DoTS	DT.529249, DT.55282291, DT.99860052
NIA Mouse Gene Index	U032918
EC	2.5.1.-
Consensus CDS Project	CCDS24839.1
International Mouse Knockout Project Status	Cox10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005891	VEGA Gene Model | MGI Sequence Detail	116842	C57BL/6J
transcript	OTTMUST00000013112	VEGA | MGI Sequence Detail	2915	Not Applicable
polypeptide	OTTMUSP00000006085	VEGA | MGI Sequence Detail	443	Not Applicable

All sequences(57) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(493 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006369	Protohaem IX farnesyltransferase
InterPro	IPR016315	Protohaem IX farnesyltransferase, mitochondria
InterPro	IPR000537	UbiA prenyltransferase family
Protein Ontology	PR:000005769	protoheme IX farnesyltransferase, mitochondrial

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:188773 Diaz F, et al., A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions. Hum Mol Genet. 2012 Dec 1;21(23):5066-77
All references(45)

Other accession IDs

MGI:2144433