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Cox10
Gene Detail
 Symbol
Name
ID
Cox10
cytochrome c oxidase assembly protein 10
MGI:1917633
Synonyms 2410004F01Rik
Feature Type protein coding gene
Genetic Map
Chromosome 11
39.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:63962627-64079468 bp, - strand
From VEGA annotation of GRCm38

  116842 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:80170  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protoheme IX farnesyltransferase, mitochondrial type
Gene Tree: Cox10

Human
homologs
Human Homolog COX10, cytochrome c oxidase assembly homolog 10 (yeast)
NCBI Gene ID 1352
neXtProt AC  NX_Q12887
Human Chr (Location)  17p12; chr17:14069402-14208679 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human COX10
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Human Diseases Modeled Using Mouse Cox10 (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Cox10 interacts with 213 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process aerobic respiration, cellular respiration, ...
Component integral component of membrane, membrane, ...
Function 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity, 4-hydroxybenzoate octaprenyltransferase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (108)    Tissues (97)    Images (17)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 108
cDNA source data(43)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(43) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005891 (Evidence)
Ensembl Gene ModelENSMUSG00000042148 (Evidence)
Entrez Gene70383 (Evidence)
UniGene340211
DFCITC1575820, TC1610514
DoTSDT.529249, DT.55282291, DT.99860052
NIA Mouse Gene IndexU032918
EC2.5.1.-
Consensus CDS ProjectCCDS24839.1
International Mouse Knockout Project StatusCox10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005891 VEGA Gene Model | MGI Sequence Detail 116842 C57BL/6J ±  kb
transcript OTTMUST00000013112 VEGA | MGI Sequence Detail 2915 Not Applicable 
polypeptide OTTMUSP00000006085 VEGA | MGI Sequence Detail 443 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(890 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006369 Protohaem IX farnesyltransferase
InterPro IPR016315 Protohaem IX farnesyltransferase, mitochondria
InterPro IPR000537 UbiA prenyltransferase family
Protein Ontology PR:000005769 protoheme IX farnesyltransferase, mitochondrial
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:188773 Diaz F, et al., A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions. Hum Mol Genet. 2012 Dec 1;21(23):5066-77
All references(46)
Disease annotation references (2)
Other
accession IDs
MGI:2144433

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory