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Ica1l Gene Detail
Summary
  • Symbol
    Ica1l
  • Name
    islet cell autoantigen 1-like
  • Synonyms
    1700030B17Rik, Als2cr15, b2b3465Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917625
    NCBI Gene: 70375
Location & Maps
more
  • Sequence Map
    Chr1:59982490-60043184 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60695 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.45 cM, cytoband C2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ICA1L, islet cell autoantigen 1 like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ICA1L, islet cell autoantigen 1 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS2CR14, ALS2CR15
  • Links
    NCBI Gene ID: 130026
    neXtProt AC: NX_Q8NDH6
    UniProt: Q8NDH6

  • Chr Location
    2q33.2; chr2:202773150-202871985 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    21 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ica1l
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for a hypomorphic allele exhibit reduced male fertility with oligospermia, globospermia, and abnormal spermiogenesis, sperm nucleus and mitochondrial sheath morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047263 VEGA Gene Model | MGI Sequence Detail 60695 C57BL/6J ±  kb
transcript OTTMUST00000122201 VEGA | MGI Sequence Detail 1320 Not Applicable  
polypeptide OTTMUSP00000067111 VEGA | MGI Sequence Detail 439 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    309 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
Other
Accession IDs
less
MGI:5648232
References
more
  • Summaries
    All 33
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:233657 He J, et al., ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. J Cell Sci. 2015 Oct 15;128(20):3822-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory