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Ica1l Gene Detail
Summary
  • Symbol
    Ica1l
  • Name
    islet cell autoantigen 1-like
  • Synonyms
    1700030B17Rik, Als2cr15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917625
    NCBI Gene: 70375
Location & Maps
more
  • Sequence Map
    Chr1:59982490-60043184 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60695 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 30.45 cM, cytoband C2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ICA1L, islet cell autoantigen 1 like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ICA1L, islet cell autoantigen 1 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS2CR14, ALS2CR15
  • Links
    NCBI Gene ID: 130026
    neXtProt AC: NX_Q8NDH6

  • Chr Location
    2q33.2; chr2:202773150-202871985 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Ica1l
  • Incidental Mutations
Mice homozygous for a hypomorphic allele exhibit reduced male fertility with oligospermia, globospermia, and abnormal spermiogenesis, sperm nucleus and mitochondrial sheath morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047263 VEGA Gene Model | MGI Sequence Detail 60695 C57BL/6J ±  kb
transcript OTTMUST00000122201 VEGA | MGI Sequence Detail 1320 Not Applicable  
polypeptide OTTMUSP00000067111 VEGA | MGI Sequence Detail 439 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    309 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Gene Ontology 1
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:233657 He J, et al., ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. J Cell Sci. 2015 Oct 15;128(20):3822-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory