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Lman1 Gene Detail
Summary
  • Symbol
    Lman1
  • Name
    lectin, mannose-binding, 1
  • Synonyms
    2610020P13Rik, ERGIC53, F5F8D, gp58, MCFD1, MR60, P58
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917611
    NCBI Gene: 70361
  • Gene Overview
    MyGene.info: LMAN1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:65980754-66022580 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41827 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 39.08 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LMAN1, lectin, mannose binding 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LMAN1, lectin, mannose binding 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERGIC53, ERGIC-53, F5F8D, FMFD1, gp58, MCFD1, MR60
  • Links
    NCBI Gene ID: 3998
    neXtProt AC: NX_P49257
    UniProt: P49257

  • Chr Location
    18q21.32; chr18:59327823-59359276 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit strain dependent postnatal lethality, slightly dilated endoplasmic reticulum in hepatocytes, and decreased serum levels of factor V and VII and aspartate transaminase with accumulation of those proteins in those ER of hepatocytes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000030654 VEGA Gene Model | MGI Sequence Detail 41827 C57BL/6J ±  kb
    transcript OTTMUST00000075892 VEGA | MGI Sequence Detail 3563 Not Applicable  
    polypeptide OTTMUSP00000039858 VEGA | MGI Sequence Detail 517 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      368 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2147213, MGI:2147326
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 4
      Gene Ontology 15
      Phenotypes 12
    • Earliest
      J:33331 Nishiguchi S, et al., A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996 Apr;119(4):749-67
    • Latest
      J:262681 Zhu M, et al., Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct functions in vivo. Blood Adv. 2018 May 8;2(9):1014-1021

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory