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Lman1
Gene Detail
 Symbol
Name
ID
Lman1
lectin, mannose-binding, 1
MGI:1917611
Synonyms 2610020P13Rik, ERGIC53, F5F8D, gp58, MCFD1, MR60, P58
Feature Type protein coding gene
Genetic Map
Chromosome 18
39.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:65980754-66022580 bp, - strand
From VEGA annotation of GRCm38

  41827 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4070  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: L-type lectin, animal type
Gene Tree: Lman1

Human
homologs
Human Homolog LMAN1, lectin, mannose-binding, 1
NCBI Gene ID 3998
neXtProt AC  NX_P49257
Human Synonyms  ERGIC53, ERGIC-53, F5F8D, FMFD1, gp58, MCFD1, MR60
Human Chr (Location)  18q21.3-q22; chr18:59327823-59359276 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LMAN1
Alleles
and
phenotypes
All alleles(11) : Targeted(2) Gene trapped(9)
 
Mice homozygous for a gene trap allele exhibit strain dependent postnatal lethality and slightly dilated endoplasmic reticulum in hepatocytes.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process endoplasmic reticulum organization, ER to Golgi vesicle-mediated transport, ...
Component cell, endoplasmic reticulum, ...
Function identical protein binding, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 1
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000030654 (Evidence)
Ensembl Gene ModelENSMUSG00000041891 (Evidence)
Entrez Gene70361 (Evidence)
DFCITC1572392, TC1600867, TC1620541, TC1624676
DoTSDT.534731, DT.101141419, DT.55268347, DT.91294863, DT.94241947
NIA Mouse Gene IndexU038506
Consensus CDS ProjectCCDS29313.1
International Mouse Knockout Project StatusLman1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030654 VEGA Gene Model | MGI Sequence Detail 41827 C57BL/6J ±  kb
transcript OTTMUST00000075892 VEGA | MGI Sequence Detail 3563 Not Applicable 
polypeptide OTTMUSP00000039858 VEGA | MGI Sequence Detail 517 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(376 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR005052 Legume-like lectin
Protein Ontology PR:000009850 protein ERGIC-53
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:177067 Zhang B, et al., Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of {alpha}1-antitrypsin. Blood. 2011 Sep 22;118(12):3384-91
All references(51)
Other
accession IDs
MGI:2147213, MGI:2147326

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory