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Gtpbp3 Gene Detail
Summary
  • Symbol
    Gtpbp3
  • Name
    GTP binding protein 3
  • Synonyms
    2410009F13Rik, Gtpbp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917609
    NCBI Gene: 70359
  • Gene Overview
    MyGene.info: GTPBP3
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr8:71488103-71499583 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 34.43 cM, cytoband C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917609
protein coding gene Chr8:71486144-71499624 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033749
protein coding gene Chr8:71886328-71898557 (+)
A/J MGP_AJ_G0033732
protein coding gene Chr8:68959253-68970692 (+)
AKR/J MGP_AKRJ_G0033657
protein coding gene Chr8:70992167-71005297 (+)
BALB/cJ MGP_BALBcJ_G0033728
protein coding gene Chr8:69130872-69141508 (+)
C3H/HeJ MGP_C3HHeJ_G0033438
protein coding gene Chr8:71571819-71582498 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034246
protein coding gene Chr8:74626810-74638443 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031188
protein coding gene Chr8:63599412-63610947 (+)
CAST/EiJ MGP_CASTEiJ_G0032763
protein coding gene Chr8:71036566-71047928 (+)
CBA/J MGP_CBAJ_G0033416
protein coding gene Chr8:77269615-77281467 (+)
DBA/2J MGP_DBA2J_G0033570
protein coding gene Chr8:68690266-68702398 (+)
FVB/NJ MGP_FVBNJ_G0033512
protein coding gene Chr8:67770389-67781535 (+)
LP/J MGP_LPJ_G0033657
protein coding gene Chr8:71861958-71874997 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033559
protein coding gene Chr8:79824331-79835773 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034263
protein coding gene Chr8:71057099-71067785 (+)
PWK/PhJ MGP_PWKPhJ_G0032470
protein coding gene Chr8:67965776-67977691 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032307
protein coding gene Chr8:70003952-70015391 (+)
WSB/EiJ MGP_WSBEiJ_G0032878
protein coding gene Chr8:71405079-71416391 (+)



Homology
more
  • Human Ortholog
    GTPBP3, GTP binding protein 3, mitochondrial
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GTPBP3, GTP binding protein 3, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COXPD23, GTPBG3, MSS1, MTGP1, THDF1
  • Links
    NCBI Gene ID: 84705
    neXtProt AC: NX_Q969Y2
    UniProt: Q969Y2

  • Chr Location
    19p13.11; chr19:17334982-17342731 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GTPBP3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormalities in chorion, placenta and trophoblast layer morphology and partial preweaning lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007610 Ensembl Gene Model | MGI Sequence Detail 11481 C57BL/6J ±  kb
    transcript ENSMUST00000168847 Ensembl | MGI Sequence Detail 2803 Not Applicable  
    polypeptide ENSMUSP00000126761 Ensembl | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008335 tRNA modification GTPase GTPBP3, mitochondrial
    • InterPro Domains
      IPR006073 GTP binding domain
      IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
      IPR018948 GTP-binding protein TrmE, N-terminal
      IPR025867 MnmE, helical domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR005225 Small GTP-binding protein domain
      IPR031168 TrmE-type guanine nucleotide-binding domain
      IPR004520 tRNA modification GTPase MnmE
      IPR027368 tRNA modification GTPase MnmE domain 2
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 2
      cDNA 9

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142594
    References
    more
    • Summaries
      All 33
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/19/2020
    MGI 6.15
    The Jackson Laboratory