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Ppp4r1 Gene Detail
Summary
  • Symbol
    Ppp4r1
  • Name
    protein phosphatase 4, regulatory subunit 1
  • Synonyms
    3110001J10Rik, Pp4r1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917601
    NCBI Gene: 70351
  • Gene Overview
    MyGene.info: PPP4R1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:65782573-65841926 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 35.26 cM, cytoband E1.2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    225 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917601
protein coding gene Chr17:65782378-65841926 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023980
protein coding gene Chr17:67936577-67997684 (+)
A/J MGP_AJ_G0023938
protein coding gene Chr17:65897798-65957321 (+)
AKR/J MGP_AKRJ_G0023907
protein coding gene Chr17:66818893-66887585 (+)
BALB/cJ MGP_BALBcJ_G0023939
protein coding gene Chr17:65849577-65912837 (+)
C3H/HeJ MGP_C3HHeJ_G0023703
protein coding gene Chr17:67708891-67773068 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024385
protein coding gene Chr17:70554116-70619827 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021831
protein coding gene Chr17:61931328-61994870 (+)
CAST/EiJ MGP_CASTEiJ_G0023185
protein coding gene Chr17:68048014-68111172 (+)
CBA/J MGP_CBAJ_G0023679
protein coding gene Chr17:73312325-73383630 (+)
DBA/2J MGP_DBA2J_G0023807
protein coding gene Chr17:64645002-64708839 (+)
FVB/NJ MGP_FVBNJ_G0023773
protein coding gene Chr17:64133426-64193467 (+)
LP/J MGP_LPJ_G0023889
protein coding gene Chr17:68650911-68713257 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023801
protein coding gene Chr17:73416060-73480850 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024429
protein coding gene Chr17:67276969-67341430 (+)
PWK/PhJ MGP_PWKPhJ_G0022931
protein coding gene Chr17:63892915-63977728 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022742
protein coding gene Chr17:63962835-64025175 (+)
WSB/EiJ MGP_WSBEiJ_G0023251
protein coding gene Chr17:67988224-68049470 (+)



Homology
more
  • Human Ortholog
    PPP4R1, protein phosphatase 4 regulatory subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPP4R1, protein phosphatase 4 regulatory subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEG1, PP4R1, PP4(Rmeg)
  • Links
    NCBI Gene ID: 9989
    neXtProt AC: NX_Q8TF05
    UniProt: Q8TF05

  • Chr Location
    18p11.22; chr18:9546791-9615274 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 81737
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PPP4R1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061950 Ensembl Gene Model | MGI Sequence Detail 59354 C57BL/6J ±  kb
transcript ENSMUST00000073104 Ensembl | MGI Sequence Detail 3850 Not Applicable  
polypeptide ENSMUSP00000072848 Ensembl | MGI Sequence Detail 951 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 6
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:237306 Hwang J, et al., Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes. J Biol Chem. 2016 Sep 30;291(40):21008-21019

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory