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Basp1 Gene Detail
Summary
  • Symbol
    Basp1
  • Name
    brain abundant, membrane attached signal protein 1
  • Synonyms
    2610024P12Rik, CAP-23, CAP23, Ckap3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917600
    NCBI Gene: 70350
  • Alliance
    genome feature page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:25363363-25413850 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 9.16 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1652 from dbSNP Build 142
  • Strain Annotations
    20
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917600
 protein coding gene Chr15:25363363-25413850 (-)
129S1/SvImJ ENSMUSG00200026570
 protein coding gene Chr15:22374889-22425377 (-)
A/J ENSMUSG00195013699
 protein coding gene Chr15:22320939-22371245 (-)
AKR/J ENSMUSG00220036904
 protein coding gene Chr1:61585243-61587069 (+)
AKR/J ENSMUSG00220047024
 protein coding gene Chr15:22171066-22221565 (-)
BALB/cJ ENSMUSG00180005297
 protein coding gene Chr15:22254905-22305401 (-)
C3H/HeJ ENSMUSG00175004401
 protein coding gene Chr15:22389326-22439767 (-)
C57BL/6NJ ENSMUSG00215005046
 protein coding gene Chr15:22310847-22361345 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019694
 protein coding gene Chr15:20781409-20831781 (-)
CAST/EiJ ENSTCUG00005014721
 protein coding gene Chr15:22368461-22419015 (-)
CBA/J ENSMUSG00210024179
 protein coding gene Chr15:22365466-22415951 (-)
DBA/2J ENSMUSG00185023221
 protein coding gene Chr15:22358006-22408495 (-)
FVB/NJ ENSMUSG00205012597
 protein coding gene Chr15:22281185-22331493 (-)
JF1/MsJ ENSUMUG00000010940
 protein coding gene Chr15:22354198-22404900 (-)
LP/J ENSMUSG00230015046
 protein coding gene Chr15:25844677-25895162 (-)
NOD/ShiLtJ ENSMUSG00190011662
 protein coding gene Chr15:22328574-22379070 (-)
NZO/HlLtJ ENSMUSG00225031704
 protein coding gene Chr15:26070902-26121340 (-)
PWK/PhJ ENSLUMG00010021282
 protein coding gene Chr15:22465942-22516604 (-)
SPRET/EiJ ENSMSPG00010023214
 protein coding gene Chr15:22882747-22933231 (-)
WSB/EiJ ENSIUOG00005020357
 protein coding gene Chr15:22371158-22421647 (-)



Homology
more
  • Human Ortholog
    BASP1, brain abundant membrane attached signal protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BASP1, brain abundant membrane attached signal protein 1
  • Synonyms
    CAP-23, CAP23, NAP-22, NAP22
  • Links
    NCBI Gene ID: 10409
    UniProt: P80723

  • Chr Location
    5p15.1; chr5:17065598-17276843 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    1 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality, hyperactivity, decreased body weight, and defects in neurite axon outgrowth, Schwann cell morphology, and brain ventricle size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    35
  • cDNA Data
    109
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70350 NCBI Gene Model | MGI Sequence Detail 50488 C57BL/6J ±  kb
    transcript NM_027395 RefSeq | MGI Sequence Detail 1855 C57BL/6  
    polypeptide Q91XV3 UniProt | EBI | MGI Sequence Detail 226 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 109
      Other 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1929858
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:363362 Meng Z, et al., Myeloid-specific ablation of Basp1 ameliorates diet-induced NASH in mice by attenuating pro-inflammatory signaling. Hepatology. 2024 Feb 1;79(2):409-424
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory