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Shprh Gene Detail
Summary
  • Symbol
    Shprh
  • Name
    SNF2 histone linker PHD RING helicase
  • Synonyms
    2610103K11Rik, D230017O13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917581
    NCBI Gene: 268281
  • Gene Overview
    MyGene.info: SHPRH
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:11149427-11217595 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 3.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917581
protein coding gene Chr10:11149319-11217595 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017012
protein coding gene Chr10:8518888-8589368 (+)
A/J MGP_AJ_G0016990
protein coding gene Chr10:8132088-8202158 (+)
AKR/J MGP_AKRJ_G0016954
protein coding gene Chr10:8334908-8403014 (+)
BALB/cJ MGP_BALBcJ_G0016948
protein coding gene Chr10:8144864-8213088 (+)
C3H/HeJ MGP_C3HHeJ_G0016773
protein coding gene Chr10:8500052-8568370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017410
protein coding gene Chr10:8719669-8794309 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015115
protein coding gene Chr10:7527286-7598216 (+)
CAST/EiJ MGP_CASTEiJ_G0016355
protein coding gene Chr10:8358750-8433265 (+)
CBA/J MGP_CBAJ_G0016745
protein coding gene Chr10:9029623-9102377 (+)
DBA/2J MGP_DBA2J_G0016853
protein coding gene Chr10:8050343-8118580 (+)
FVB/NJ MGP_FVBNJ_G0016848
protein coding gene Chr10:7952593-8021538 (+)
LP/J MGP_LPJ_G0016928
protein coding gene Chr10:8316017-8386341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016878
protein coding gene Chr10:8946429-9033430 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017448
protein coding gene Chr10:8271217-8341464 (+)
PWK/PhJ MGP_PWKPhJ_G0016140
protein coding gene Chr10:7969140-8039891 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015923
protein coding gene Chr10:8316597-8390882 (+)
WSB/EiJ MGP_WSBEiJ_G0016417
protein coding gene Chr10:8289522-8358946 (+)



Homology
more
  • Human Ortholog
    SHPRH, SNF2 histone linker PHD RING helicase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SHPRH, SNF2 histone linker PHD RING helicase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA545I5.2
  • Links
    NCBI Gene ID: 257218
    neXtProt AC: NX_Q149N8
    UniProt: Q149N8

  • Chr Location
    6q24.3; chr6:145857838-145964436 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6489
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SHPRH
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    6 phenotype references
The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000090112 Ensembl Gene Model | MGI Sequence Detail 68169 C57BL/6J ±  kb
transcript ENSMUST00000044053 Ensembl | MGI Sequence Detail 9271 Not Applicable  
polypeptide ENSMUSP00000039422 Ensembl | MGI Sequence Detail 1674 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 7
Other
Accession IDs
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MGI:2441961, MGI:2446137, MGI:3035103, MGI:3035296
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:235620 Qu Y, et al., Axitinib blocks Wnt/beta-catenin signaling and directs asymmetric cell division in cancer. Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9339-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory