Bclaf1 MGI Mouse Gene Detail - MGI:1917580 - BCL2-associated transcription factor 1

Symbol

Bclaf1
Name

BCL2-associated transcription factor 1
Synonyms

2610102K23Rik, 2700025J07Rik, 2810454G14Rik, 5730534O06Rik, mKIAA0164

Feature Type

protein coding gene
IDs

MGI:1917580
NCBI Gene: 72567
Gene Overview

MyGene.info: BCLAF1
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:20312078-20342644 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 9.75 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

90 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917580	protein coding gene	Chr10:20312078-20344613 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0017054	protein coding gene	Chr10:18055151-18088410 (+)
A/J	MGP_AJ_G0017032	protein coding gene	Chr10:17367501-17399665 (+)
AKR/J	MGP_AKRJ_G0016996	protein coding gene	Chr10:17681627-17716552 (+)
BALB/cJ	MGP_BALBcJ_G0016990	protein coding gene	Chr10:17436273-17468364 (+)
C3H/HeJ	MGP_C3HHeJ_G0016815	protein coding gene	Chr10:17996659-18028781 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017452	protein coding gene	Chr10:18510977-18543040 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015157	protein coding gene	Chr10:16363269-16396181 (+)
CAST/EiJ	MGP_CASTEiJ_G0016397	protein coding gene	Chr10:17866362-17899969 (+)
CBA/J	MGP_CBAJ_G0016787	protein coding gene	Chr10:19342479-19376677 (+)
DBA/2J	MGP_DBA2J_G0016895	protein coding gene	Chr10:17252723-17284888 (+)
FVB/NJ	MGP_FVBNJ_G0016890	protein coding gene	Chr10:17007238-17039433 (+)
LP/J	MGP_LPJ_G0016970	protein coding gene	Chr10:17856569-17891506 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016920	protein coding gene	Chr10:19586384-19623415 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017490	protein coding gene	Chr10:17663229-17695906 (+)
PWK/PhJ	MGP_PWKPhJ_G0016182	protein coding gene	Chr10:17127982-17161293 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015965	protein coding gene	Chr10:17808895-17845334 (+)
WSB/EiJ	MGP_WSBEiJ_G0016459	protein coding gene	Chr10:17747500-17779603 (+)

Human Ortholog

BCLAF1, BCL2 associated transcription factor 1

Vertebrate Orthologs

8

Human Ortholog

BCLAF1, BCL2 associated transcription factor 1
Orthology source: HomoloGene, HGNC
Synonyms

bK211L9.1, BTF
Links

HGNC:16863

NCBI Gene ID: 9774

neXtProt AC: NX_Q9NYF8

UniProt: Q9NYF8
Chr Location

6q23.3; chr6:136256863-136290645 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8832
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed
HCOP

human homology predictions: BCLAF1
Gene Tree

Bclaf1

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Chemically induced (other)

1
Gene trapped

65
Targeted

5
Genomic Mutations

1 involving Bclaf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit postnatal lethality, impaired lung development, and T cell and B cell homeostasis abnormalities.

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All GO Annotations

14
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

87
Tissues

74
cDNA Data

405
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bclaf1

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Bclaf1 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

102
RefSeq

15
UniProt

11
CCDS

CCDS23721.1, CCDS35858.1, CCDS78798.1
UniGene

294783

Ensembl

ENSMUSG00000037608 (Evidence)
NCBI Gene

72567

			Length	Strain/Species	Flank
genomic	72567	NCBI Gene Model \| MGI Sequence Detail	30567	C57BL/6J	± kb
transcript	NM_001025392	RefSeq \| MGI Sequence Detail	5454	Not Specified
polypeptide	Q8K019	UniProt \| EBI \| MGI Sequence Detail	919	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000004706 bcl-2-associated transcription factor 1

(term hierarchy)
InterPro Domains

IPR026668 Bcl-2-associated transcription factor 1

IPR029199 THRAP3/BCLAF1 family

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All nucleic 406

cDNA 406

Microarray probesets 7

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MGI:1914501, MGI:1917913, MGI:1919817, MGI:2143607, MGI:2143868

Summaries

All 55

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Bclaf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92593	Chr10:20312363-20312400 (+)	304 bp
Tssr92594	Chr10:20312461-20312492 (+)	399 bp
Tssr92595	Chr10:20312498-20312518 (+)	430 bp
Tssr92596	Chr10:20312524-20312539 (+)	454 bp
Tssr92599	Chr10:20325375-20325399 (+)	13,309 bp
Tssr92603	Chr10:20339751-20339767 (+)	27,681 bp
Tssr92604	Chr10:20341226-20341230 (+)	29,150 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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