Bclaf1 MGI Mouse Gene Detail - MGI:1917580 - BCL2-associated transcription factor 1

Bclaf1 Gene Detail

Symbol

Bclaf1
Name

BCL2-associated transcription factor 1
Synonyms

2610102K23Rik, 2700025J07Rik, 2810454G14Rik, 5730534O06Rik, mKIAA0164

Feature Type

protein coding gene
IDs

MGI:1917580
NCBI Gene: 72567
Gene Overview

MyGene.info: BCLAF1

Sequence Map

Chr10:20312472-20344613 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

32142 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 9.75 cM, cytoband A3
Mapping Data

3 experiments

Human Ortholog

BCLAF1, BCL2 associated transcription factor 1

Vertebrate Orthologs

8

Human Ortholog

BCLAF1, BCL2 associated transcription factor 1
Orthology source: HomoloGene, HGNC
Synonyms

bK211L9.1, BTF
Links

HGNC:16863

NCBI Gene ID: 9774

neXtProt AC: NX_Q9NYF8

UniProt: Q9NYF8
Chr Location

6q23.3; chr6:136256863-136290645 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8832
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed
HCOP

human homology predictions: BCLAF1
Gene Tree

Bclaf1

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Chemically induced (other)

1
Gene trapped

65
Targeted

5
Genomic Mutations

1 involving Bclaf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

49 strains or lines available

Mice homozygous for a knock-out allele exhibit postnatal lethality, impaired lung development, and T cell and B cell homeostasis abnormalities.

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All GO Annotations

17
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

87
Tissues

74
cDNA Data

404
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Bclaf1 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

100
RefSeq

15
UniProt

11
CCDS

CCDS23721.1, CCDS35858.1, CCDS78798.1
UniGene

294783

			Length	Strain/Species	Flank
genomic	OTTMUSG00000049448	VEGA Gene Model \| MGI Sequence Detail	32142	C57BL/6J	± kb
transcript	OTTMUST00000126053	VEGA \| MGI Sequence Detail	5437	Not Applicable
polypeptide	OTTMUSP00000068204	VEGA \| MGI Sequence Detail	919	Not Applicable

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SNPs within 2kb

97 from dbSNP Build 142

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UniProt

11 Sequences
Protein Ontology

PR:000004706 bcl-2-associated transcription factor 1

(term hierarchy)
InterPro Domains

IPR026668 Bcl-2-associated transcription factor 1

IPR029199 THRAP3/BCLAF1 family

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All nucleic 405

cDNA 405

Microarray probesets 7

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MGI:1914501, MGI:1917913, MGI:1919817, MGI:2143607, MGI:2143868

Summaries

All 54

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 21
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/10/2017 MGI 6.10