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Bclaf1 Gene Detail
Summary
  • Symbol
    Bclaf1
  • Name
    BCL2-associated transcription factor 1
  • Synonyms
    2610102K23Rik, 2700025J07Rik, 2810454G14Rik, 5730534O06Rik, mKIAA0164
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917580
    NCBI Gene: 72567
  • Gene Overview
    MyGene.info: BCLAF1
Location & Maps
more
  • Sequence Map
    Chr10:20312472-20344613 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      32142 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 9.75 cM, cytoband A3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BCLAF1, BCL2 associated transcription factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    BCLAF1, BCL2 associated transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bK211L9.1, BTF
  • Links
    NCBI Gene ID: 9774
    neXtProt AC: NX_Q9NYF8
    UniProt: Q9NYF8

  • Chr Location
    6q23.3; chr6:136256863-136290645 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality, impaired lung development, and T cell and B cell homeostasis abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    87
  • Tissues
    74
  • cDNA Data
    404
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049448 VEGA Gene Model | MGI Sequence Detail 32142 C57BL/6J ±  kb
transcript OTTMUST00000126053 VEGA | MGI Sequence Detail 5437 Not Applicable  
polypeptide OTTMUSP00000068204 VEGA | MGI Sequence Detail 919 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    97 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 405
    cDNA 405

    Microarray probesets 7
Other
Accession IDs
less
MGI:1914501, MGI:1917913, MGI:1919817, MGI:2143607, MGI:2143868
References
more
  • Summaries
    All 54
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/08/2017
MGI 6.10 		The Jackson Laboratory