Bclaf1
Gene Detail

Symbol Name ID

Bclaf1 BCL2-associated transcription factor 1 MGI:1917580

Synonyms

2610102K23Rik, 2700025J07Rik, 2810454G14Rik, 5730534O06Rik, mKIAA0164

Feature Type

protein coding gene

Genetic Map

Chromosome 10

9.75 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:20312469-20342501 bp, + strand From NCBI annotation of GRCm38   30033 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8832  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Bclaf1

Human homologs

Human Homolog		BCLAF1, BCL2-associated transcription factor 1
NCBI Gene ID		9774
neXtProt AC		NX_Q9NYF8
Human Synonyms		bK211L9.1, BTF
Human Chr (Location)		6q22-q23; chr6:136256863-136290645 (-)  GRCh38

Alleles and phenotypes

All alleles(70) : Gene trapped(65) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit postnatal lethality, impaired lung development, and T cell and B cell homeostasis abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	apoptotic process, negative regulation of transcription, DNA-templated, ...
Component	cytoplasm, nucleus
Function	DNA binding, poly(A) RNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (87)    Tissues (66)    Images (18)
Theiler Stages: 17, 18, 19, 21, 23, 28

Assay Type	Results
RNA in situ	87

cDNA source data(404)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(405) cDNA(405)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000037608 (Evidence)
Entrez Gene	72567 (Evidence)
UniGene	294783
DFCI	TC1572476, TC1586962, TC1597873, TC1598633, TC1608094, TC1648520
DoTS	DT.101180566, DT.101363002, DT.101384106, DT.101711209, DT.103577370, DT.103577371, DT.110593473, DT.55222318, DT.94290376
NIA Mouse Gene Index	U011319
Consensus CDS Project	CCDS23721.1, CCDS35858.1
International Mouse Knockout Project Status	Bclaf1

Sequences

Length	Strain/Species
genomic	72567	NCBI Gene Model | MGI Sequence Detail	30033	C57BL/6J
transcript	NM_001025392	RefSeq | MGI Sequence Detail	5454	Not Specified
polypeptide	Q8K019	UniProt | EBI | MGI Sequence Detail	919	Not Applicable

All sequences(81) RefSeq(14) UniProt(8)

Polymorphisms

SNPs within 2kb(87 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR026668	Bcl-2-associated transcription factor 1
Protein Ontology	PR:000004706	bcl-2-associated transcription factor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206963 Orieux G, et al., Involvement of Bcl-2-associated transcription factor 1 in the differentiation of early-born retinal cells. J Neurosci. 2014 Jan 22;34(4):1530-41
All references(48)

Other accession IDs

MGI:1914501, MGI:1917913, MGI:1919817, MGI:2143607, MGI:2143868