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Bclaf1 Gene Detail
Summary
  • Symbol
    Bclaf1
  • Name
    BCL2-associated transcription factor 1
  • Synonyms
    2610102K23Rik, 2700025J07Rik, 2810454G14Rik, 5730534O06Rik, mKIAA0164
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917580
    NCBI Gene: 72567
  • Gene Overview
    MyGene.info: BCLAF1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:20312078-20342644 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 9.75 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917580
protein coding gene Chr10:20312078-20344613 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017054
protein coding gene Chr10:18055151-18088410 (+)
A/J MGP_AJ_G0017032
protein coding gene Chr10:17367501-17399665 (+)
AKR/J MGP_AKRJ_G0016996
protein coding gene Chr10:17681627-17716552 (+)
BALB/cJ MGP_BALBcJ_G0016990
protein coding gene Chr10:17436273-17468364 (+)
C3H/HeJ MGP_C3HHeJ_G0016815
protein coding gene Chr10:17996659-18028781 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017452
protein coding gene Chr10:18510977-18543040 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015157
protein coding gene Chr10:16363269-16396181 (+)
CAST/EiJ MGP_CASTEiJ_G0016397
protein coding gene Chr10:17866362-17899969 (+)
CBA/J MGP_CBAJ_G0016787
protein coding gene Chr10:19342479-19376677 (+)
DBA/2J MGP_DBA2J_G0016895
protein coding gene Chr10:17252723-17284888 (+)
FVB/NJ MGP_FVBNJ_G0016890
protein coding gene Chr10:17007238-17039433 (+)
LP/J MGP_LPJ_G0016970
protein coding gene Chr10:17856569-17891506 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016920
protein coding gene Chr10:19586384-19623415 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017490
protein coding gene Chr10:17663229-17695906 (+)
PWK/PhJ MGP_PWKPhJ_G0016182
protein coding gene Chr10:17127982-17161293 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015965
protein coding gene Chr10:17808895-17845334 (+)
WSB/EiJ MGP_WSBEiJ_G0016459
protein coding gene Chr10:17747500-17779603 (+)



Homology
more
  • Human Ortholog
    BCLAF1, BCL2 associated transcription factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    BCLAF1, BCL2 associated transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bK211L9.1, BTF
  • Links
    NCBI Gene ID: 9774
    neXtProt AC: NX_Q9NYF8
    UniProt: Q9NYF8

  • Chr Location
    6q23.3; chr6:136256863-136290645 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality, impaired lung development, and T cell and B cell homeostasis abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72567 NCBI Gene Model | MGI Sequence Detail 30567 C57BL/6J ±  kb
    transcript NM_001025392 RefSeq | MGI Sequence Detail 5454 Not Specified  
    polypeptide Q8K019 UniProt | EBI | MGI Sequence Detail 919 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 406
      cDNA 406

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1914501, MGI:1917913, MGI:1919817, MGI:2143607, MGI:2143868
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory