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Plscr3 Gene Detail
Summary
  • Symbol
    Plscr3
  • Name
    phospholipid scramblase 3
  • Synonyms
    2210403O21Rik, 2610037N06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917560
    NCBI Gene: 70310
  • Gene Overview
    MyGene.info: PLSCR3
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69846376-69852058 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917560
protein coding gene Chr11:69846248-69852058 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018561
protein coding gene Chr11:70329414-70335096 (+)
A/J MGP_AJ_G0018529
protein coding gene Chr11:67666822-67672504 (+)
AKR/J MGP_AKRJ_G0018498
protein coding gene Chr11:69688038-69693720 (+)
BALB/cJ MGP_BALBcJ_G0018501
protein coding gene Chr11:67994959-68000641 (+)
C3H/HeJ MGP_C3HHeJ_G0018314
protein coding gene Chr11:69721573-69727255 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018952
protein coding gene Chr11:72454531-72460213 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016597
protein coding gene Chr11:64590162-64596033 (+)
CAST/EiJ MGP_CASTEiJ_G0017869
protein coding gene Chr11:69963051-69966903 (+)
CBA/J MGP_CBAJ_G0018287
protein coding gene Chr11:75692173-75697855 (+)
DBA/2J MGP_DBA2J_G0018396
protein coding gene Chr11:67250672-67256354 (+)
FVB/NJ MGP_FVBNJ_G0018386
protein coding gene Chr11:66890673-66896355 (+)
LP/J MGP_LPJ_G0018466
protein coding gene Chr11:70896056-70901738 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018409
protein coding gene Chr11:76300906-76306588 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018994
protein coding gene Chr11:69949325-69955007 (+)
PWK/PhJ MGP_PWKPhJ_G0017643
protein coding gene Chr11:67900751-67906555 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017433
protein coding gene Chr11:69767163-69772845 (+)
WSB/EiJ MGP_WSBEiJ_G0017923
protein coding gene Chr11:69617006-69622689 (+)



Homology
more
  • Human Ortholog
    PLSCR3, phospholipid scramblase 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PLSCR3, phospholipid scramblase 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 57048
    neXtProt AC: NX_Q9NRY6
    UniProt: Q9NRY6

  • Chr Location
    17p13.1; chr17:7389727-7394843 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Plscr3 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display lipid-engorged adipocytes, increased abdominal fat stores, mild hyperglycemia, dyslipidemia, impaired glucose tolerance, insulin resistance, altered plasma adiponectin and leptin levels, and impaired insulin-stimulated glucose uptake by adipocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019461 Ensembl Gene Model | MGI Sequence Detail 5683 C57BL/6J ±  kb
transcript ENSMUST00000108632 Ensembl | MGI Sequence Detail 1835 Not Applicable  
polypeptide ENSMUSP00000104272 Ensembl | MGI Sequence Detail 296 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-28121, MGI:104827, MGI:1917313
References
more
  • Summaries
    All 43
    Diseases 1
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory