Plscr3
Gene Detail

Symbol Name ID

Plscr3 phospholipid scramblase 3 MGI:1917560

Synonyms

2210403O21Rik, 2610037N06Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:69846376-69851043 bp, + strand From VEGA annotation of GRCm38   4668 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23219  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: phospholipid scramblase
Gene Tree: Plscr3

Human homologs

Human Homolog		PLSCR3, phospholipid scramblase 3
NCBI Gene ID		57048
neXtProt AC		NX_Q9NRY6
Human Chr (Location)		17p13.1; chr17:7293046-7298162 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Homozygous null mice display lipid-engorged adipocytes, increased abdominal fat stores, mild hyperglycemia, dyslipidemia, impaired glucose tolerance, insulin resistance, altered plasma adiponectin and leptin levels, and impaired insulin-stimulated glucose uptake by adipocytes.

 
Human Diseases Modeled Using Mouse Plscr3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	apoptotic process, cholesterol homeostasis, ...
Component	integral to membrane, membrane, ...
Function	calcium-dependent protein binding, SH3 domain binding

External Resources: FuncBase

Expression

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006010 (Evidence)
Ensembl Gene Model	ENSMUSG00000019461 (Evidence)
Entrez Gene	70310 (Evidence)
Consensus CDS Project	CCDS24916.1
International Mouse Knockout Project Status	Plscr3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006010	VEGA Gene Model | MGI Sequence Detail	4668	C57BL/6J
transcript	OTTMUST00000013464	VEGA | MGI Sequence Detail	1927	Not Applicable
polypeptide	OTTMUSP00000006232	VEGA | MGI Sequence Detail	296	Not Applicable

All sequences(36) RefSeq(5) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005552	Scramblase
Protein Ontology	PR:000012886	phospholipid scramblase 3

References

(Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)

Other accession IDs

MGD-MRK-28121, MGI:104827, MGI:1917313