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Plscr3
Gene Detail
Symbol

Name
ID
Plscr3
phospholipid scramblase 3
MGI:1917560
Synonyms
2210403O21Rik, 2610037N06Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:69846376-69851043 bp, + strand
From VEGA annotation of GRCm38

  4668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23219  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PLSCR3
Protein SuperFamily: phospholipid scramblase
Gene Tree: Plscr3

Human
homologs
PLSCR3, phospholipid scramblase 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57048
neXtProt AC: NX_Q9NRY6

Human Chr (Location): 17p13.1; chr17:7389727-7394843 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Genomic Mutations involving Plscr3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display lipid-engorged adipocytes, increased abdominal fat stores, mild hyperglycemia, dyslipidemia, impaired glucose tolerance, insulin resistance, altered plasma adiponectin and leptin levels, and impaired insulin-stimulated glucose uptake by adipocytes.
 
Human Diseases Modeled in Mice Using Plscr3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Plscr3 interacts with 229 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process apoptotic process, cholesterol homeostasis, ...
Component integral component of membrane, membrane, ...
Function calcium-dependent protein binding, phospholipid scramblase activity, ...
External Resources: FuncBase
Expression
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plscr3 ; ZFIN plscr3b    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006010 (Evidence)
Ensembl Gene Model ENSMUSG00000019461 (Evidence)
Entrez Gene 70310 (Evidence)
Consensus CDS Project CCDS24916.1
International Mouse Phenotyping Consortium Status Plscr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006010 VEGA Gene Model | MGI Sequence Detail 4668 C57BL/6J ±  kb
transcript OTTMUST00000013465 VEGA | MGI Sequence Detail 1835 Not Applicable 
polypeptide OTTMUSP00000006233 VEGA | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(11) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005552 Scramblase
Protein Ontology PR:000012886 phospholipid scramblase 3
References
(Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(30)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-28121, MGI:104827, MGI:1917313

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory