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Afap1 Gene Detail
Summary
  • Symbol
    Afap1
  • Name
    actin filament associated protein 1
  • Synonyms
    2600003E23Rik, 9630044L16Rik, mKIAA3018
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917542
    NCBI Gene: 70292
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:36050663-36161267 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.02 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    975 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917542
 protein coding gene Chr5:36050663-36161267 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029485
 protein coding gene Chr5:34204149-34320113 (+)
A/J MGP_AJ_G0029452
 protein coding gene Chr5:33081876-33194075 (+)
AKR/J MGP_AKRJ_G0029401
 protein coding gene Chr5:34342330-34463022 (+)
BALB/cJ MGP_BALBcJ_G0029462
 protein coding gene Chr5:33595481-33706744 (+)
C3H/HeJ MGP_C3HHeJ_G0029184
 protein coding gene Chr5:34354407-34476111 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029916
 protein coding gene Chr5:36104389-36215553 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027153
 protein coding gene Chr5:30836428-30948423 (+)
CAST/EiJ MGP_CASTEiJ_G0028593
 protein coding gene Chr5:33455610-33576245 (+)
CBA/J MGP_CBAJ_G0029152
 protein coding gene Chr5:36956383-37089101 (+)
DBA/2J MGP_DBA2J_G0029300
 protein coding gene Chr5:33226137-33337039 (+)
FVB/NJ MGP_FVBNJ_G0029259
 protein coding gene Chr5:32696440-32809771 (+)
LP/J MGP_LPJ_G0029385
 protein coding gene Chr5:34620484-34753388 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029289
 protein coding gene Chr5:37735716-37855759 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029949
 protein coding gene Chr5:33837384-33958346 (+)
PWK/PhJ MGP_PWKPhJ_G0028318
 protein coding gene Chr5:32394612-32507491 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028149
 protein coding gene Chr5:33311162-33419905 (+)
WSB/EiJ MGP_WSBEiJ_G0028674
 protein coding gene Chr5:33902794-34020301 (+)



Homology
more
  • Human Ortholog
    AFAP1, actin filament associated protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AFAP1, actin filament associated protein 1
  • Synonyms
    AFAP, AFAP110, AFAP-110
  • Links
    NCBI Gene ID: 60312
    neXtProt AC: NX_Q8N556
    UniProt: Q8N556

  • Chr Location
    4p16.1; chr4:7758713-7939926 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit inability to nurse pups due to failed secretory activation, reduced milk lipid synthesis and precocious mammary gland involution.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    674
  • Tissues
    2
  • cDNA Data
    52
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70292 NCBI Gene Model | MGI Sequence Detail 110605 C57BL/6J ±  kb
    transcript NM_001403419 RefSeq | MGI Sequence Detail 6835 C57BL/6  
    polypeptide Q80YS6 UniProt | EBI | MGI Sequence Detail 731 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140986
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 5
      Phenotypes 28
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:221250 Cunnick JM, et al., Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland. Oncogene. 2015 May 14;34(20):2640-9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/23/2022
    MGI 6.20     		The Jackson Laboratory