About   Help   FAQ
Afap1 Gene Detail
Summary
  • Symbol
    Afap1
  • Name
    actin filament associated protein 1
  • Synonyms
    2600003E23Rik, 9630044L16Rik, mKIAA3018
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917542
    NCBI Gene: 70292
  • Gene Overview
    MyGene.info: AFAP1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr5:35893319-36003923 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      110605 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.02 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AFAP1, actin filament associated protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AFAP1, actin filament associated protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AFAP, AFAP110, AFAP-110
  • Links
    NCBI Gene ID: 60312
    neXtProt AC: NX_Q8N556
    UniProt: Q8N556

  • Chr Location
    4p16.1; chr4:7758713-7939926 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 11009
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AFAP1
  • Gene Tree
    Afap1
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit inability to nurse pups due to failed secretory activation, reduced milk lipid synthesis and precocious mammary gland involution.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2
  • Tissues
    2
  • cDNA Data
    52
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024856 VEGA Gene Model | MGI Sequence Detail 110605 C57BL/6J ±  kb
    transcript OTTMUST00000061234 VEGA | MGI Sequence Detail 6618 Not Applicable  
    polypeptide OTTMUSP00000029993 VEGA | MGI Sequence Detail 731 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      992 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140986
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 4
      Phenotypes 28
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:221250 Cunnick JM, et al., Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland. Oncogene. 2015 May 14;34(20):2640-9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory