Mkrn2os Gene Detail

Summary

• Symbol
  Mkrn2os
• Name
  makorin, ring finger protein 2, opposite strand
• Synonyms
  2510049J12Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1917541
  NCBI Gene: 70291
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr6:115583547-115592576 bp, - strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 53.60 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  56 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917541	protein coding gene	Chr6:115583544-115592576 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031150	protein coding gene	Chr6:118209904-118218866 (-)
A/J	MGP_AJ_G0031119	protein coding gene	Chr6:113671807-113681078 (-)
AKR/J	MGP_AKRJ_G0031050	protein coding gene	Chr6:116733545-116743355 (-)
BALB/cJ	MGP_BALBcJ_G0031130	protein coding gene	Chr6:113486771-113496062 (-)
C3H/HeJ	MGP_C3HHeJ_G0030578	protein coding gene	Chr6:67560612-67570927 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031589	protein coding gene	Chr6:121217761-121230436 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028753	protein coding gene	Chr6:110688566-110697397 (-)
CAST/EiJ	MGP_CASTEiJ_G0030237	protein coding gene	Chr6:117093512-117103375 (-)
CBA/J	MGP_CBAJ_G0030816	protein coding gene	Chr6:125979287-125989617 (-)
DBA/2J	MGP_DBA2J_G0030969	protein coding gene	Chr6:112604689-112613689 (-)
FVB/NJ	MGP_FVBNJ_G0030923	protein coding gene	Chr6:111775835-111785452 (-)
LP/J	MGP_LPJ_G0031049	protein coding gene	Chr6:118229821-118238574 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030957	protein coding gene	Chr6:130179612-130192090 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031616	protein coding gene	Chr6:116749361-116759441 (-)
PWK/PhJ	MGP_PWKPhJ_G0029953	protein coding gene	Chr6:111613452-111621566 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029781	protein coding gene	Chr6:115463500-115472265 (-)
WSB/EiJ	MGP_WSBEiJ_G0030321	protein coding gene	Chr6:117007268-117018136 (-)

Homology

• Human Ortholog
  MKRN2OS, MKRN2 opposite strand

• Vertebrate Orthologs
  9

• Human Ortholog
  MKRN2OS, MKRN2 opposite strand
  Orthology source: HomoloGene, HGNC
• Synonyms
  C3orf83, MKRN2-AS1
• Links
  HGNC:40375

  NCBI Gene ID: 100129480

  neXtProt AC: NX_H3BPM6

  UniProt: H3BPM6

  
  
• Chr Location
  3p25.2; chr3:12539713-12561227 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 66298
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
  
• HCOP
  human homology predictions: MKRN2OS
• Gene Tree
  Mkrn2os
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  7
• Gene trapped
  2
• Spontaneous
  1
• Targeted
  4
• Genomic Mutations
  1 involving Mkrn2os
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  6 strains or lines available

Expression

• cDNA Data
  10
• Literature Summary
  1

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Mkrn2os interacts with 244 markers (Mir7-1, Mir7-2, Mir10a, ...) View All

Sequences &
Gene Models

• All Sequences
  32
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS51877.1
• UniGene
  133694

• Ensembl
  ENSMUSG00000068011 (Evidence)
• NCBI Gene
  70291

Representative Sequences			Length	Strain/Species
genomic	70291	NCBI Gene Model | MGI Sequence Detail	9030	C57BL/6J
transcript	NM_001101431	RefSeq | MGI Sequence Detail	2539	C57BL/6
polypeptide	NP_001094901	RefSeq | MGI Sequence Detail	217	C57BL/6

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR032016 Protein of unknown function DUF4796

Molecular
Reagents

• All nucleic 13

  Genomic 2

  cDNA 11

  
  

  Microarray probesets 1

References

• Summaries
  All 24

  Developmental Gene Expression 1

  Phenotypes 7
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

TSS for Mkrn2os:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr62517	Chr6:115592571-115592599 (-)	-9 bp
Tssr62516	Chr6:115592543-115592570 (-)	19 bp
Tssr62515	Chr6:115592530-115592537 (-)	42 bp
Tssr62514	Chr6:115592510-115592529 (-)	56 bp
Tssr62513	Chr6:115592493-115592503 (-)	78 bp