Krt78 Gene Detail

Summary

• Symbol
  Krt78
• Name
  keratin 78
• Synonyms
  2310030B04Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1917529
  NCBI Gene: 332131
• Gene Overview
  MyGene.info: KRT78
• Alliance
  gene page
• Transcription Start Sites
  2 TSS

Location &
Maps

• Sequence Map
  Chr15:101946001-101954287 bp, - strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 15, 57.15 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  87 from dbSNP Build 142
• Strain Annotations
  16

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917529	protein coding gene	Chr15:101946001-101996624 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022394	protein coding gene	Chr15:104079005-104086881 (-)
A/J	no annotation
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0022360	protein coding gene	Chr15:100046105-100054116 (-)
C3H/HeJ	MGP_C3HHeJ_G0022127	protein coding gene	Chr15:103088478-103098393 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022809	protein coding gene	Chr15:107948628-107956506 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020332	protein coding gene	Chr15:95782542-95790566 (-)
CAST/EiJ	MGP_CASTEiJ_G0021653	protein coding gene	Chr15:103947967-103955408 (-)
CBA/J	MGP_CBAJ_G0022096	protein coding gene	Chr15:111711671-111720654 (-)
DBA/2J	MGP_DBA2J_G0022227	protein coding gene	Chr15:99285904-99294054 (-)
FVB/NJ	MGP_FVBNJ_G0022203	protein coding gene	Chr15:98343864-98351611 (-)
LP/J	MGP_LPJ_G0022296	protein coding gene	Chr15:104234764-104244224 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022225	protein coding gene	Chr15:115328704-115336452 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022821	protein coding gene	Chr15:103047740-103055977 (-)
PWK/PhJ	MGP_PWKPhJ_G0021393	protein coding gene	Chr15:99434308-99442228 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021225	protein coding gene	Chr15:102881138-102889023 (-)
WSB/EiJ	MGP_WSBEiJ_G0021703	protein coding gene	Chr15:103672431-103680848 (-)

Homology

• Human Ortholog
  KRT78, keratin 78

• Vertebrate Orthologs
  7

• Human Ortholog
  KRT78, keratin 78
  Orthology source: HomoloGene, HGNC
• Synonyms
  CK-78, K5B, K78, Kb40
• Links
  HGNC:28926

  NCBI Gene ID: 196374

  neXtProt AC: NX_Q8N1N4

  UniProt: Q8N1N4

  
  
• Chr Location
  12q13.13; chr12:52837804-52848994 (-)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 65261
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
  
• HCOP
  human homology predictions: KRT78
• Gene Tree
  Krt78
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  24 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Radiation induced
  2
• Targeted
  3
• Genomic Mutations
  4 involving Krt78
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  36 strains or lines available

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• cDNA Data
  7

• Other Mouse Links
  GEO
  Expression Atlas

Interactions

• Krt78 interacts with 33 markers (Mir24-1, Mir24-2, Mir150, ...) View All

Sequences &
Gene Models

• All Sequences
  42
• RefSeq
  6
• UniProt
  6
• CCDS
  CCDS49736.1
• UniGene
  325105

• Ensembl
  ENSMUSG00000050463 (Evidence)
• NCBI Gene
  332131

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000050463	Ensembl Gene Model | MGI Sequence Detail	8287	C57BL/6J
transcript	ENSMUST00000164932	Ensembl | MGI Sequence Detail	3437	Not Applicable
polypeptide	ENSMUSP00000126197	Ensembl | MGI Sequence Detail	1068	Not Applicable

Protein
Information

• UniProt
  6 Sequences
• InterPro Domains
  IPR001664 Intermediate filament protein
  IPR039008 Intermediate filament, rod domain
  IPR003054 Keratin, type II
  IPR032444 Keratin type II head

Molecular
Reagents

• All nucleic 7

  cDNA 7

  
  

  Microarray probesets 2

References

• Summaries
  All 40

  Diseases 1

  Phenotypes 24
• Earliest
  J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
• Latest
  J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

TSS for Krt78:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136646	Chr15:101954276-101954294 (-)	2 bp
Tssr136645	Chr15:101954249-101954265 (-)	30 bp