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Dazap1 Gene Detail
Summary
  • Symbol
    Dazap1
  • Name
    DAZ associated protein 1
  • Synonyms
    2410042M16Rik, mPrrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917498
    NCBI Gene: 70248
  • Gene Overview
    MyGene.info: DAZAP1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80261486-80288408 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917498
protein coding gene Chr10:80261467-80288413 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017492
protein coding gene Chr10:80858786-80886260 (+)
A/J MGP_AJ_G0017470
protein coding gene Chr10:78025571-78053789 (+)
AKR/J MGP_AKRJ_G0017431
protein coding gene Chr10:80157026-80187824 (+)
BALB/cJ MGP_BALBcJ_G0017432
protein coding gene Chr10:78256893-78284561 (+)
C3H/HeJ MGP_C3HHeJ_G0017255
protein coding gene Chr10:80253506-80282967 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017886
protein coding gene Chr10:83647606-83690138 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015574
protein coding gene Chr10:74248449-74275447 (+)
CAST/EiJ MGP_CASTEiJ_G0016822
protein coding gene Chr10:80458355-80487035 (+)
CBA/J MGP_CBAJ_G0017227
protein coding gene Chr10:86888445-86915254 (+)
DBA/2J MGP_DBA2J_G0017333
protein coding gene Chr10:77246495-77273285 (+)
FVB/NJ MGP_FVBNJ_G0017327
protein coding gene Chr10:76431620-76460582 (+)
LP/J MGP_LPJ_G0017404
protein coding gene Chr10:81331467-81359991 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017353
protein coding gene Chr10:88832381-88860761 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017927
protein coding gene Chr10:80143334-80176288 (+)
PWK/PhJ MGP_PWKPhJ_G0016603
protein coding gene Chr10:77114031-77141776 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016392
protein coding gene Chr10:79124253-79150830 (+)
WSB/EiJ MGP_WSBEiJ_G0016882
protein coding gene Chr10:80179451-80209776 (+)



Homology
more
  • Human Ortholog
    DAZAP1, DAZ associated protein 1
  • Vertebrate Orthologs
    2
  • Human Ortholog
    DAZAP1, DAZ associated protein 1
    Orthology source: HGNC
  • Links
    NCBI Gene ID: 26528
    neXtProt AC: NX_Q96EP5
    UniProt: Q96EP5

  • Chr Location
    19p13.3; chr19:1407569-1435687 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show partial lethality during fetal growth through weaning, growth retardation, spermatogenic arrest, and premature death. Homozygotes for a hypomorphic allele live longer but are small and sterile and display small gonads, spermatogenic arrest, and abnormal pregnancy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069565 Ensembl Gene Model | MGI Sequence Detail 26923 C57BL/6J ±  kb
    transcript ENSMUST00000105361 Ensembl | MGI Sequence Detail 1537 Not Applicable  
    polypeptide ENSMUSP00000101000 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR034134 DAZ-associated protein 1, RNA recognition motif 1
      IPR034131 DAZ-associated protein 1, RNA recognition motif 2
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 90
      Primer pair 3
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:210719 Chen HY, et al., DAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts. Nucleic Acids Res. 2013 Nov;41(21):9858-69

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory