Ufsp1 MGI Mouse Gene Detail - MGI:1917490 - UFM1-specific peptidase 1

Symbol

Ufsp1
Name

UFM1-specific peptidase 1
Synonyms

2700038N03Rik, D5Ertd655e

Feature Type

protein coding gene
IDs

MGI:1917490
NCBI Gene: 70240
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:137292931-137293926 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 76.33 cM
Mapping Data

3 experiments

SNPs within 2kb

98 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917490	protein coding gene	Chr5:137292891-137293927 (+)
129S1/SvImJ	ENSMUSG00200042556	protein coding gene	Chr5:131087295-131088331 (+)
A/J	ENSMUSG00195048210	protein coding gene	Chr5:130589988-130591024 (+)
AKR/J	ENSMUSG00220047437	protein coding gene	Chr5:130065324-130066360 (+)
BALB/cJ	ENSMUSG00180035831	protein coding gene	Chr5:130686555-130687591 (+)
C3H/HeJ	ENSMUSG00175044909	protein coding gene	Chr5:132614101-132615137 (+)
C57BL/6NJ	ENSMUSG00215047562	protein coding gene	Chr5:130735954-130736990 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027869	protein coding gene	Chr5:130100109-130101156 (+)
CAST/EiJ	ENSTCUG00005009479	protein coding gene	Chr5:129957412-129958448 (+)
CBA/J	ENSMUSG00210006382	protein coding gene	Chr5:131431670-131432706 (+)
DBA/2J	ENSMUSG00185052417	protein coding gene	Chr5:134447060-134448096 (+)
FVB/NJ	ENSMUSG00205045220	protein coding gene	Chr5:130331500-130332536 (+)
JF1/MsJ	ENSUMUG00000022768	protein coding gene	Chr5:137337441-137338477 (+)
LP/J	ENSMUSG00230042939	protein coding gene	Chr5:138560540-138561576 (+)
NOD/ShiLtJ	ENSMUSG00190037922	protein coding gene	Chr5:130386349-130387385 (+)
NZO/HlLtJ	ENSMUSG00225023251	protein coding gene	Chr5:146235803-146236839 (+)
PWK/PhJ	ENSLUMG00010017784	protein coding gene	Chr5:129193907-129194943 (+)
SPRET/EiJ	ENSMSPG00010033526	protein coding gene	Chr5:132596532-132597507 (+)
WSB/EiJ	ENSIUOG00005033933	protein coding gene	Chr5:133037355-133038391 (+)

Human Ortholog

UFSP1, UFM1 specific peptidase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UFSP1, UFM1 specific peptidase 1
Synonyms

UFSP
Links

HGNC:33821

NCBI Gene ID: 402682

UniProt: Q6NVU6
Chr Location

7q22.1; chr7:100888721-100889715 (-) GRCh38

MGI Vertebrate Homology

Ufsp1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: UFSP1
Gene Tree

Ufsp1

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

2
Gene trapped

1
Find Mice (IMSR)

6 strains or lines available

Homozygous null mice show mild alterations of the neuromuscular synapse, but show normal skeletal muscle morphology and function.

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All GO Annotations

17
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

806
Tissues

32
cDNA Data

15
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS19764.1

Ensembl

ENSMUSG00000051502 (Evidence)
NCBI Gene

70240

			Length	Strain/Species	Flank
genomic	70240	NCBI Gene Model \| MGI Sequence Detail	996	C57BL/6J	± kb
transcript	NM_027356	RefSeq \| MGI Sequence Detail	1018	C57BL/6
polypeptide	Q9CZP0	UniProt \| EBI \| MGI Sequence Detail	217	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032517 Ufm1-specific protease 1

(term hierarchy)
PDB

2Z84
EC

3.4.22.-
InterPro Domains

IPR012462 UFSP1/2/DUB, catalytic domain

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All nucleic 16

cDNA 15

Primer pair 1

Antibodies 1

Microarray probesets 3

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MGI:1277240

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 3
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:372394 Calvo C, et al., Loss of Ufsp1 does not cause major changes at the neuromuscular junction. PLoS One. 2025;20(8):e0328690

TSS for Ufsp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49326	Chr5:137292866-137292902 (+)	-47 bp
Tssr49327	Chr5:137292903-137292927 (+)	-16 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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