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Rnf168
Gene Detail
 Symbol
Name
ID
Rnf168
ring finger protein 168
MGI:1917488
Synonyms 3110001H15Rik
Feature Type protein coding gene
Genetic Map
Chromosome 16
22.51 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:32277459-32300906 bp, + strand
From VEGA annotation of GRCm38

  23448 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:87044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Rnf168

Human
homologs
Human Homolog RNF168, ring finger protein 168, E3 ubiquitin protein ligase
NCBI Gene ID 165918
neXtProt AC  NX_Q8IYW5
Human Synonyms  hRNF168
Human Chr (Location)  3q29; chr3:196468783-196503768 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RNF168
Alleles
and
phenotypes
All alleles(59) : Gene trapped(57) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit immunodeficient, increased radiosensitivity and age-dependent reduction in male infertility.
 
Human Diseases Modeled Using Mouse Rnf168 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process cellular response to DNA damage stimulus, chromatin modification, ...
Component mitochondrion, nucleus, ...
Function chromatin binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (52)    Tissues (31)    Images (5)
Theiler Stages: 17, 21, 23
Assay TypeResults
RNA in situ 52
cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000025774 (Evidence)
Ensembl Gene ModelENSMUSG00000014074 (Evidence)
Entrez Gene70238 (Evidence)
DFCITC1579051, TC1763190
DoTSDT.101734804, DT.40136609, DT.91316066, DT.91574526
NIA Mouse Gene IndexU017014
EC6.3.2.-
Consensus CDS ProjectCCDS49825.1
International Mouse Knockout Project StatusRnf168
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025774 VEGA Gene Model | MGI Sequence Detail 23448 C57BL/6J ±  kb
transcript OTTMUST00000063481 VEGA | MGI Sequence Detail 3932 Not Applicable 
polypeptide OTTMUSP00000031384 VEGA | MGI Sequence Detail 565 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000014101 E3 ubiquitin-protein ligase RNF168
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:184808 Luijsterburg MS, et al., A new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure. EMBO J. 2012;31(11):2511-27
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory