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Rnf168
Gene Detail
Symbol

Name
ID
Rnf168
ring finger protein 168
MGI:1917488
Synonyms
3110001H15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 16
22.51 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:32277459-32300906 bp, + strand
From VEGA annotation of GRCm38

  23448 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:87044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RNF168
Gene Tree: Rnf168

Human
homologs
RNF168, ring finger protein 168, E3 ubiquitin protein ligase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 165918
neXtProt AC: NX_Q8IYW5

Human Synonyms: hRNF168

Human Chr (Location): 3q29; chr3:196468783-196503768 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RNF168

Mutations,
alleles, and
phenotypes
All mutations/alleles(59) : Gene trapped(57) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit immunodeficient, increased radiosensitivity and age-dependent reduction in male infertility.
 
Human Diseases Modeled in Mice Using Rnf168 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Rnf168 interacts with 217 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cellular response to DNA damage stimulus, chromatin modification, ...
Component cytoplasm, nucleoplasm, ...
Function chromatin binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (52)    Tissues (31)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 52
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rnf168 ; ZFIN rnf168    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000025774 (Evidence)
Ensembl Gene Model ENSMUSG00000014074 (Evidence)
Entrez Gene 70238 (Evidence)
DFCI TC1763190, TC1579051
DoTS DT.101734804, DT.91316066, DT.40136609, DT.91574526
NIA Mouse Gene Index U017014
EC 6.3.2.-
Consensus CDS Project CCDS49825.1
International Mouse Phenotyping Consortium Status Rnf168
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025774 VEGA Gene Model | MGI Sequence Detail 23448 C57BL/6J ±  kb
transcript OTTMUST00000063481 VEGA | MGI Sequence Detail 3932 Not Applicable 
polypeptide OTTMUSP00000031384 VEGA | MGI Sequence Detail 565 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000014101 E3 ubiquitin-protein ligase RNF168
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218138 Munoz MC, et al., An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells. Nucleic Acids Res. 2014 Jul;42(12):7720-33
All references(35)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory