About   Help   FAQ
Rnf168 Gene Detail
Summary
  • Symbol
    Rnf168
  • Name
    ring finger protein 168
  • Synonyms
    3110001H15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917488
    NCBI Gene: 70238
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32277459-32301434 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 22.51 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917488
protein coding gene Chr16:32277459-32301442 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022735
protein coding gene Chr16:30332575-30361822 (+)
A/J MGP_AJ_G0022700
protein coding gene Chr16:28900947-28924964 (+)
AKR/J MGP_AKRJ_G0022673
protein coding gene Chr16:29953363-29977256 (+)
BALB/cJ MGP_BALBcJ_G0022702
protein coding gene Chr16:29053294-29073681 (+)
C3H/HeJ MGP_C3HHeJ_G0022467
protein coding gene Chr16:30082526-30109366 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023151
protein coding gene Chr16:30971521-30998358 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020669
protein coding gene Chr16:29272441-29299522 (+)
CAST/EiJ MGP_CASTEiJ_G0021995
protein coding gene Chr16:30205564-30230790 (+)
CBA/J MGP_CBAJ_G0022437
protein coding gene Chr16:32219734-32248737 (+)
DBA/2J MGP_DBA2J_G0022570
protein coding gene Chr16:28755334-28777181 (+)
FVB/NJ MGP_FVBNJ_G0022545
protein coding gene Chr16:28736906-28759185 (+)
LP/J MGP_LPJ_G0022637
protein coding gene Chr16:30111093-30132176 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022564
protein coding gene Chr16:31675644-31698344 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023163
protein coding gene Chr16:29931644-29955183 (+)
PWK/PhJ MGP_PWKPhJ_G0021734
protein coding gene Chr16:29072008-29096532 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021565
protein coding gene Chr16:29728362-29750245 (+)
WSB/EiJ MGP_WSBEiJ_G0022039
protein coding gene Chr16:29875900-29898328 (+)



Homology
more
  • Human Ortholog
    RNF168, ring finger protein 168
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RNF168, ring finger protein 168
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hRNF168
  • Links
    NCBI Gene ID: 165918
    neXtProt AC: NX_Q8IYW5
    UniProt: Q8IYW5

  • Chr Location
    3q29; chr3:196468783-196503768 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Rnf168 mouse models; 1 with human RNF168 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 1 genetic background
    5 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit immunodeficient, increased radiosensitivity and age-dependent reduction in male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014074 Ensembl Gene Model | MGI Sequence Detail 23976 C57BL/6J ±  kb
    transcript ENSMUST00000171474 Ensembl | MGI Sequence Detail 4460 Not Applicable  
    polypeptide ENSMUSP00000126484 Ensembl | MGI Sequence Detail 567 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 6
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:274082 Zong D, et al., BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Mol Cell. 2019 Mar 21;73(6):1267-1281.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/04/2019
    MGI 6.14
    The Jackson Laboratory