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Poc1a Gene Detail
Summary
  • Symbol
    Poc1a
  • Name
    POC1 centriolar protein A
  • Synonyms
    2510040D07Rik, cha, Wdr51a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917485
    NCBI Gene: 70235
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106281022-106349891 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.46 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    604 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917485
protein coding gene Chr9:106281022-106350521 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035226
protein coding gene Chr9:108079892-108149408 (+)
A/J MGP_AJ_G0035206
protein coding gene Chr9:104177246-104246393 (+)
AKR/J MGP_AKRJ_G0035138
protein coding gene Chr9:106773003-106842146 (+)
BALB/cJ MGP_BALBcJ_G0035199
protein coding gene Chr9:103860611-103930502 (+)
C3H/HeJ MGP_C3HHeJ_G0034909
protein coding gene Chr9:107181706-107251794 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035719
protein coding gene Chr9:111050909-111123826 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032617
protein coding gene Chr9:101668426-101737480 (+)
CAST/EiJ MGP_CASTEiJ_G0034221
protein coding gene Chr9:107077482-107150650 (+)
CBA/J MGP_CBAJ_G0034878
protein coding gene Chr9:114947992-115040585 (+)
DBA/2J MGP_DBA2J_G0035039
protein coding gene Chr9:103636694-103706003 (+)
FVB/NJ MGP_FVBNJ_G0034987
protein coding gene Chr9:102413483-102484527 (+)
LP/J MGP_LPJ_G0035115
protein coding gene Chr9:108298846-108370219 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035026
protein coding gene Chr9:116593521-116663060 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035741
protein coding gene Chr9:107014620-107086222 (+)
PWK/PhJ MGP_PWKPhJ_G0033928
protein coding gene Chr9:103930169-104001275 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033763
protein coding gene Chr9:107076278-107149055 (+)
WSB/EiJ MGP_WSBEiJ_G0034341
protein coding gene Chr9:106914461-106985581 (+)



Homology
more
  • Human Ortholog
    POC1A, POC1 centriolar protein A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POC1A, POC1 centriolar protein A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PIX2, SOFT, WDR51A
  • Links
    NCBI Gene ID: 25886
    neXtProt AC: NX_Q8NBT0
    UniProt: Q8NBT0

  • Chr Location
    3p21.2; chr3:52075233-52154690 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 51460
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: POC1A
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for this mutation exhibit disproportionate dwarfism and male infertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70235 NCBI Gene Model | MGI Sequence Detail 68870 C57BL/6J ±  kb
transcript NM_027354 RefSeq | MGI Sequence Detail 1707 C57BL/6  
polypeptide Q8JZX3 UniProt | EBI | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 3
Other
Accession IDs
less
MGI:2135613
References
more
  • Summaries
    All 35
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:227335 Geister KA, et al., LINE-1 Mediated Insertion into Poc1a (Protein of Centriole 1 A) Causes Growth Insufficiency and Male Infertility in Mice. PLoS Genet. 2015 Oct;11(10):e1005569

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory