Rbm25 MGI Mouse Gene Detail - MGI:1914289 - RNA binding motif protein 25

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Rbm25 Gene Detail

Symbol

Rbm25
Name

RNA binding motif protein 25
Synonyms

2600011C06Rik, 2610015J01Rik, A130095G20Rik

Feature Type

protein coding gene
IDs

MGI:1914289
NCBI Gene: 67039
Alliance

gene page
Transcription Start Sites

28 TSS

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Sequence Map

Chr12:83678990-83729901 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 38.81 cM, cytoband D3
Mapping Data

3 experiments

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SNPs within 2kb

206 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1914289	protein coding gene	Chr12:83678010-83729901 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019915	protein coding gene	Chr12:84277968-84331501 (+)
A/J	MGP_AJ_G0019872	protein coding gene	Chr12:81081994-81138449 (+)
AKR/J	MGP_AKRJ_G0019848	protein coding gene	Chr12:83270933-83334903 (+)
BALB/cJ	MGP_BALBcJ_G0019852	protein coding gene	Chr12:81433411-81485772 (+)
C3H/HeJ	MGP_C3HHeJ_G0019658	protein coding gene	Chr12:83738683-83799112 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020304	protein coding gene	Chr12:86695923-86748536 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017921	protein coding gene	Chr12:78009311-78061156 (+)
CAST/EiJ	MGP_CASTEiJ_G0019207	protein coding gene	Chr12:78676301-78729418 (+)
CBA/J	MGP_CBAJ_G0019629	protein coding gene	Chr12:90021324-90086124 (+)
DBA/2J	MGP_DBA2J_G0019744	protein coding gene	Chr12:80629322-80683520 (+)
FVB/NJ	MGP_FVBNJ_G0019730	protein coding gene	Chr12:79572826-79631379 (+)
LP/J	MGP_LPJ_G0019816	protein coding gene	Chr12:84148532-84205392 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019769	protein coding gene	Chr12:92993373-93061649 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020338	protein coding gene	Chr12:82873615-82927173 (+)
PWK/PhJ	MGP_PWKPhJ_G0018971	protein coding gene	Chr12:75102761-75155471 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018766	protein coding gene	Chr12:77336919-77478921 (+)
WSB/EiJ	MGP_WSBEiJ_G0019259	protein coding gene	Chr12:83539928-83600283 (+)

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Human Ortholog

RBM25, RNA binding motif protein 25

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBM25, RNA binding motif protein 25
Synonyms

fSAP94, NET52, RED120, RNPC7, S164, Snu71
Links

HGNC:23244

NCBI Gene ID: 58517

neXtProt AC: NX_P49756

UniProt: P49756
Chr Location

14q24.2; chr14:73058532-73123899 (+) GRCh38

MGI Vertebrate Homology

Rbm25 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RBM25
Gene Tree

Rbm25

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

158
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

156
Genomic Mutations

1 involving Rbm25
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

22
cDNA Data

266
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rbm25

ZFIN rbm25b

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All Sequences

132
RefSeq

42
UniProt

11
CCDS

CCDS49107.1

Ensembl

ENSMUSG00000010608 (Evidence)
NCBI Gene

67039

Representative Sequences				Length	Strain/Species	Flank
	genomic	67039	NCBI Gene Model \| MGI Sequence Detail	50912	C57BL/6J	± kb
	transcript	NM_001364415	RefSeq \| MGI Sequence Detail	4340	C57BL/6
	polypeptide	B2RY56	UniProt \| EBI \| MGI Sequence Detail	838	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000013790 RNA-binding protein 25

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR002483 PWI domain

IPR036483 PWI domain superfamily

IPR034268 RBM25, RNA recognition motif

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

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All nucleic 267

cDNA 266

Primer pair 1

Microarray probesets 12

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MGI:1917471, MGI:2144767, MGI:2144925, MGI:2144966, MGI:3034522

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Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:337874 Bramlett C, et al., RNA splicing factor Rbm25 underlies heterogeneous preleukemic clonal expansion in mice. Blood. 2023 Jun 15;141(24):2961-2972

TSS for Rbm25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114260	Chr12:83678968-83678977 (+)	-17 bp
Tssr114261	Chr12:83678982-83679099 (+)	51 bp
Tssr114263	Chr12:83688274-83688279 (+)	9,287 bp
Tssr114264	Chr12:83689407-83689449 (+)	10,438 bp
Tssr114265	Chr12:83691161-83691199 (+)	12,190 bp
Tssr114266	Chr12:83692927-83692967 (+)	13,957 bp
Tssr114267	Chr12:83698064-83698096 (+)	19,090 bp
Tssr114268	Chr12:83700203-83700207 (+)	21,215 bp
Tssr114269	Chr12:83706192-83706199 (+)	27,206 bp
Tssr114270	Chr12:83706202-83706213 (+)	27,218 bp
Tssr114271	Chr12:83706274-83706289 (+)	27,292 bp
Tssr114272	Chr12:83706290-83706301 (+)	27,306 bp
Tssr114273	Chr12:83706328-83706342 (+)	27,345 bp
Tssr114274	Chr12:83707076-83707107 (+)	28,102 bp
Tssr114275	Chr12:83707364-83707419 (+)	28,402 bp
Tssr114276	Chr12:83710685-83710701 (+)	31,703 bp
Tssr114277	Chr12:83710868-83710878 (+)	31,883 bp
Tssr114278	Chr12:83710906-83710946 (+)	31,936 bp
Tssr114279	Chr12:83710968-83711006 (+)	31,997 bp
Tssr114280	Chr12:83714859-83714878 (+)	35,879 bp
Tssr114281	Chr12:83714895-83714932 (+)	35,924 bp
Tssr114282	Chr12:83718678-83718699 (+)	39,699 bp
Tssr114283	Chr12:83719502-83719518 (+)	40,520 bp
Tssr114284	Chr12:83719607-83719633 (+)	40,630 bp
Tssr114285	Chr12:83721809-83721827 (+)	42,828 bp
Tssr114286	Chr12:83729321-83729334 (+)	50,338 bp
Tssr114287	Chr12:83729692-83729703 (+)	50,708 bp
Tssr114288	Chr12:83729747-83729771 (+)	50,769 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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