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Tmem143 Gene Detail
Summary
  • Symbol
    Tmem143
  • Name
    transmembrane protein 143
  • Synonyms
    2310076O21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917459
    NCBI Gene: 70209
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45896990-45917418 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.58 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    244 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917459
protein coding gene Chr7:45896941-45917418 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032254
protein coding gene Chr7:46222845-46243798 (+)
A/J MGP_AJ_G0032233
protein coding gene Chr7:45295656-45315878 (+)
AKR/J MGP_AKRJ_G0032169
protein coding gene Chr7:46571058-46591353 (+)
BALB/cJ MGP_BALBcJ_G0032245
protein coding gene Chr7:45295675-45316368 (+)
C3H/HeJ MGP_C3HHeJ_G0031960
protein coding gene Chr7:47050893-47072063 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032737
protein coding gene Chr7:48486980-48510089 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029751
protein coding gene Chr7:47848609-47866387 (+)
CAST/EiJ MGP_CASTEiJ_G0031288
protein coding gene Chr7:38498649-38522660 (+)
CBA/J MGP_CBAJ_G0031925
protein coding gene Chr7:50111820-50133328 (+)
DBA/2J MGP_DBA2J_G0032082
protein coding gene Chr7:44975687-44996525 (+)
FVB/NJ MGP_FVBNJ_G0032034
protein coding gene Chr7:44758904-44778545 (+)
LP/J MGP_LPJ_G0032161
protein coding gene Chr7:46930411-46950929 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032071
protein coding gene Chr7:48780778-48802218 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032752
protein coding gene Chr7:45770635-45793464 (+)
PWK/PhJ MGP_PWKPhJ_G0031011
protein coding gene Chr7:38346648-38367517 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030849
protein coding gene Chr7:33800333-33822193 (+)
WSB/EiJ MGP_WSBEiJ_G0031406
protein coding gene Chr7:46275408-46297205 (+)



Homology
more
  • Human Ortholog
    TMEM143, transmembrane protein 143
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TMEM143, transmembrane protein 143
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55260
    neXtProt AC: NX_Q96AN5
    UniProt: Q96AN5

  • Chr Location
    19q13.33; chr19:48332356-48364237 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70209 NCBI Gene Model | MGI Sequence Detail 20429 C57BL/6J ±  kb
transcript NM_144801 RefSeq | MGI Sequence Detail 2184 C57BL/6  
polypeptide Q8VD26 UniProt | EBI | MGI Sequence Detail 458 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141987
References
more
  • Summaries
    All 28
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory