Med23
Gene Detail

Symbol Name ID

Med23 mediator complex subunit 23 MGI:1917458

Synonyms

3000002A17Rik, Crsp3, ESTM7, mKIAA1216, Sur2, X83317

Feature Type

protein coding gene

Genetic Map

Chromosome 10

12.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:24869986-24913681 bp, + strand From VEGA annotation of GRCm38   43696 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3552  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Med23

Human homologs

Human Homolog		MED23, mediator complex subunit 23
NCBI Gene ID		9439
neXtProt AC		NX_Q9ULK4
Human Synonyms		ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR2, SUR-2
Human Chr (Location)		6q22.33-q24.1; chr6:131895106-131949379 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MED23

Alleles and phenotypes

All alleles(10) : Targeted(4) Gene trapped(6)
 

Homozygous null mice display embryonic lethality during organogenesis with disorganization of the vasculature and peripheral nervous system.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	regulation of transcription, DNA-dependent, transcription, DNA-dependent
Component	mediator complex, nucleus, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (25)    Tissues (16)    Images (3)
Theiler Stages: 23

Assay Type	Results
RNA in situ	25

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(9)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000039802 (Evidence)
Ensembl Gene Model	ENSMUSG00000019984 (Evidence)
Entrez Gene	70208 (Evidence)
DFCI	TC1575074, TC1591951, TC1594583, TC1742863
DoTS	DT.101303404, DT.491882, DT.55229246, DT.97394581
NIA Mouse Gene Index	U011349
Consensus CDS Project	CCDS35871.2, CCDS48522.1
International Mouse Knockout Project Status	Med23

Sequences

Length	Strain/Species
genomic	OTTMUSG00000039802	VEGA Gene Model | MGI Sequence Detail	43696	C57BL/6J
transcript	OTTMUST00000103466	VEGA | MGI Sequence Detail	5098	Not Applicable
polypeptide	OTTMUSP00000057813	VEGA | MGI Sequence Detail	1376	Not Applicable

All sequences(67) RefSeq(4) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(388 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021629	Mediator complex, subunit Med23
Protein Ontology	PR:000010295	mediator of RNA polymerase II transcription subunit 23

References

(Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:187746 Yin JW, et al., Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev. 2012 Oct 1;26(19):2192-205
All references(43)

Other accession IDs

MGD-MRK-28117, MGI:104823