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Med23 Gene Detail
Summary
  • Symbol
    Med23
  • Name
    mediator complex subunit 23
  • Synonyms
    3000002A17Rik, Crsp3, ESTM7, mKIAA1216, Sur2, X83317
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917458
    NCBI Gene: 70208
  • Gene Overview
    MyGene.info: MED23
Location & Maps
more
  • Sequence Map
    Chr10:24869986-24913681 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43696 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 12.26 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MED23, mediator complex subunit 23
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED23, mediator complex subunit 23
    Orthology source: HomoloGene
  • Synonyms
    ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR2, SUR-2
  • Links
    NCBI Gene ID: 9439
    neXtProt AC: NX_Q9ULK4

  • Chr Location
    6q22.33-q24.1; chr6:131573966-131628239 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3552
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MED23
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MED23 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Recessive 18; MRT18   OMIM: 614249
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    7
  • Genomic Mutations
    1 involving Med23
  • Incidental Mutations
Homozygous null mice display embryonic lethality during organogenesis with disorganization of the vasculature and peripheral nervous system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039802 VEGA Gene Model | MGI Sequence Detail 43696 C57BL/6J ±  kb
transcript OTTMUST00000103466 VEGA | MGI Sequence Detail 5098 Not Applicable  
polypeptide OTTMUSP00000057813 VEGA | MGI Sequence Detail 1376 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    522 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000010295 mediator of RNA polymerase II transcription subunit 23
  • InterPro Domains
    IPR021629 Mediator complex, subunit Med23
Molecular
Reagents
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  • All nucleic 130
    cDNA 130

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-28117, MGI:104823
References
more
  • Summaries
    All 44
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
  • Latest
    J:217860 Kasper LH, et al., T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. PLoS One. 2014;9(7):e102076

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory