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Med23 Gene Detail
Summary
  • Symbol
    Med23
  • Name
    mediator complex subunit 23
  • Synonyms
    3000002A17Rik, Crsp3, ESTM7, mKIAA1216, Sur2, X83317
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917458
    NCBI Gene: 70208
  • Gene Overview
    MyGene.info: MED23
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:24869986-24913529 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 12.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    520 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917458
protein coding gene Chr10:24869986-24913681 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017095
protein coding gene Chr10:22866436-22911660 (+)
A/J MGP_AJ_G0017072
protein coding gene Chr10:22191497-22235229 (+)
AKR/J MGP_AKRJ_G0017032
protein coding gene Chr10:22566704-22611062 (+)
BALB/cJ MGP_BALBcJ_G0017035
protein coding gene Chr10:22287096-22333100 (+)
C3H/HeJ MGP_C3HHeJ_G0016855
protein coding gene Chr10:22774453-22819546 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017493
protein coding gene Chr10:23571563-23616244 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015191
protein coding gene Chr10:20880587-20927121 (+)
CAST/EiJ MGP_CASTEiJ_G0016434
protein coding gene Chr10:22704278-22752554 (+)
CBA/J MGP_CBAJ_G0016829
protein coding gene Chr10:24643431-24688967 (+)
DBA/2J MGP_DBA2J_G0016934
protein coding gene Chr10:21922167-21965693 (+)
FVB/NJ MGP_FVBNJ_G0016929
protein coding gene Chr10:21620503-21665433 (+)
LP/J MGP_LPJ_G0017011
protein coding gene Chr10:22850452-22904494 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016959
protein coding gene Chr10:24752785-24797890 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017529
protein coding gene Chr10:22419755-22463625 (+)
PWK/PhJ MGP_PWKPhJ_G0016216
protein coding gene Chr10:21708428-21753178 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016000
protein coding gene Chr10:22246277-22299546 (+)
WSB/EiJ MGP_WSBEiJ_G0016497
protein coding gene Chr10:22547713-22596024 (+)



Homology
more
  • Human Ortholog
    MED23, mediator complex subunit 23
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MED23, mediator complex subunit 23
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR2, SUR-2
  • Links
    NCBI Gene ID: 9439
    neXtProt AC: NX_Q9ULK4
    UniProt: Q9ULK4

  • Chr Location
    6q23.2; chr6:131573966-131628239 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3552
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MED23
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MED23 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis with disorganization of the vasculature and peripheral nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70208 NCBI Gene Model | MGI Sequence Detail 43544 C57BL/6J ±  kb
transcript NM_001166416 RefSeq | MGI Sequence Detail 4946 C57BL/6  
polypeptide Q80YQ2 UniProt | EBI | MGI Sequence Detail 1367 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 131
    cDNA 131

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-28117, MGI:104823
References
more
  • Summaries
    All 54
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory