About   Help   FAQ
Med23
Gene Detail
 Symbol
Name
ID
Med23
mediator complex subunit 23
MGI:1917458
Synonyms 3000002A17Rik, Crsp3, ESTM7, mKIAA1216, Sur2, X83317
Feature Type protein coding gene
Genetic Map
Chromosome 10
12.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:24869986-24913681 bp, + strand
From VEGA annotation of GRCm38

  43696 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3552  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Med23

Human
homologs
Human Homolog MED23, mediator complex subunit 23
NCBI Gene ID 9439
neXtProt AC  NX_Q9ULK4
Human Synonyms  ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR2, SUR-2
Human Chr (Location)  6q22.33-q24.1; chr6:131573966-131628239 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MED23
Alleles
and
phenotypes
All alleles(12) : Gene trapped(6) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality during organogenesis with disorganization of the vasculature and peripheral nervous system.
 
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated
Component mediator complex, nucleus, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (25)    Tissues (16)    Images (3)
Theiler Stages: 23
Assay TypeResults
RNA in situ 25
cDNA source data(130)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(130) cDNA(130)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000039802 (Evidence)
Ensembl Gene ModelENSMUSG00000019984 (Evidence)
Entrez Gene70208 (Evidence)
UniGene28020
DFCITC1575074, TC1591951, TC1594583, TC1742863
DoTSDT.101303404, DT.491882, DT.55229246, DT.97394581
NIA Mouse Gene IndexU011349
Consensus CDS ProjectCCDS35871.2, CCDS48522.1
International Mouse Knockout Project StatusMed23
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039802 VEGA Gene Model | MGI Sequence Detail 43696 C57BL/6J ±  kb
transcript OTTMUST00000103466 VEGA | MGI Sequence Detail 5098 Not Applicable 
polypeptide OTTMUSP00000057813 VEGA | MGI Sequence Detail 1376 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(4) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(531 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021629 Mediator complex, subunit Med23
Protein Ontology PR:000010295 mediator of RNA polymerase II transcription subunit 23
References (Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:187746 Yin JW, et al., Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation. Genes Dev. 2012 Oct 1;26(19):2192-205
All references(46)
Other
accession IDs
MGD-MRK-28117, MGI:104823

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory