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Lrch3 Gene Detail
Summary
  • Symbol
    Lrch3
  • Name
    leucine-rich repeats and calponin homology (CH) domain containing 3
  • Synonyms
    2210409B11Rik, LOC385628
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917394
    NCBI Gene: 70144
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32914100-33015647 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 23.46 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    584 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917394
protein coding gene Chr16:32914093-33016029 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022749
protein coding gene Chr16:31041555-31152673 (+)
A/J MGP_AJ_G0022714
protein coding gene Chr16:29555840-29680448 (+)
AKR/J MGP_AKRJ_G0022687
protein coding gene Chr16:30617579-30725369 (+)
BALB/cJ MGP_BALBcJ_G0022716
protein coding gene Chr16:29696748-29799055 (+)
C3H/HeJ MGP_C3HHeJ_G0022481
protein coding gene Chr16:30741839-30851463 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023165
protein coding gene Chr16:31706935-31827426 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020683
protein coding gene Chr16:29922746-30034657 (+)
CAST/EiJ MGP_CASTEiJ_G0022009
protein coding gene Chr16:30893640-30999391 (+)
CBA/J MGP_CBAJ_G0022451
protein coding gene Chr16:32978638-33103833 (+)
DBA/2J MGP_DBA2J_G0022584
protein coding gene Chr16:29403366-29504859 (+)
FVB/NJ MGP_FVBNJ_G0022559
protein coding gene Chr16:29388675-29495648 (+)
LP/J MGP_LPJ_G0022651
protein coding gene Chr16:30805484-30918645 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022578
protein coding gene Chr16:32391265-32509240 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023177
protein coding gene Chr16:30606884-30731529 (+)
PWK/PhJ MGP_PWKPhJ_G0021748
protein coding gene Chr16:29739839-29845377 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021579
protein coding gene Chr16:30405511-30527849 (+)
WSB/EiJ MGP_WSBEiJ_G0022053
protein coding gene Chr16:30573956-30699432 (+)



Homology
more
  • Human Ortholog
    LRCH3, leucine rich repeats and calponin homology domain containing 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LRCH3, leucine rich repeats and calponin homology domain containing 3
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 84859
    neXtProt AC: NX_Q96II8
    UniProt: Q96II8

  • Chr Location
    3q29; chr3:197790855-197889346 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022801 Ensembl Gene Model | MGI Sequence Detail 101548 C57BL/6J ±  kb
transcript ENSMUST00000135193 Ensembl | MGI Sequence Detail 2794 Not Applicable  
polypeptide ENSMUSP00000130708 Ensembl | MGI Sequence Detail 796 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR001715 Calponin homology domain
    IPR036872 CH domain superfamily
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 6
Other
Accession IDs
less
MGI:2146632, MGI:2686588
References
more
  • Summaries
    All 26
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory