Slc44a4 MGI Mouse Gene Detail - MGI:1917379 - solute carrier family 44, member 4

Symbol

Slc44a4
Name

solute carrier family 44, member 4
Synonyms

2210409B01Rik, NG22

Feature Type

protein coding gene
IDs

MGI:1917379
NCBI Gene: 70129
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:35133442-35149412 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.46 cM, cytoband B2
Mapping Data

2 experiments

Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917379	protein coding gene	Chr17:35133200-35149412 (+)
129S1/SvImJ	ENSMUSG00200048595	protein coding gene	Chr17:30837555-30853521 (+)
A/J	ENSMUSG00195040783	protein coding gene	Chr17:31737718-31753677 (+)
AKR/J	ENSMUSG00220049314	protein coding gene	Chr17:30766399-30782364 (+)
BALB/cJ	ENSMUSG00180039397	protein coding gene	Chr17:31107592-31123552 (+)
C3H/HeJ	ENSMUSG00175034204	protein coding gene	Chr17:30652518-30668482 (+)
C57BL/6NJ	ENSMUSG00215050803	protein coding gene	Chr17:30677749-30693715 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021484	protein coding gene	Chr17:31653408-31670388 (+)
CAST/EiJ	ENSTCUG00005048302	protein coding gene	Chr17:31696179-31712156 (+)
CBA/J	ENSMUSG00210044501	protein coding gene	Chr17:30474626-30490590 (+)
DBA/2J	ENSMUSG00185050979	protein coding gene	Chr17:33126835-33142793 (+)
FVB/NJ	ENSMUSG00205052072	protein coding gene	Chr17:30996355-31012339 (+)
JF1/MsJ	ENSUMUG00000049398	protein coding gene	Chr17:32379656-32395858 (+)
LP/J	ENSMUSG00230054574	protein coding gene	Chr17:34235812-34251782 (+)
NOD/ShiLtJ	ENSMUSG00190041504	protein coding gene	Chr17:30597323-30613303 (+)
NZO/HlLtJ	ENSMUSG00225054177	protein coding gene	Chr17:36248958-36264928 (+)
PWK/PhJ	ENSLUMG00010038907	protein coding gene	Chr17:30214211-30230405 (+)
SPRET/EiJ	ENSMSPG00010048266	protein coding gene	Chr17:31400804-31416788 (+)
WSB/EiJ	ENSIUOG00005049787	protein coding gene	Chr17:31324930-31340934 (+)

Human Ortholog

SLC44A4, solute carrier family 44 member 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC44A4, solute carrier family 44 member 4
Synonyms

C6orf29, CTL4, DFNA72, hTPPT1, NG22, TPPT
Links

HGNC:13941

NCBI Gene ID: 80736

UniProt: Q53GD3
Chr Location

6p21.33; chr6:31863192-31879198 (-) GRCh38

MGI Vertebrate Homology

Slc44a4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC44A4
Gene Tree

Slc44a4

Diseases

1 with human SLC44A4 associations

				Human Disease	Mouse Models
				autosomal dominant nonsyndromic deafness 72 IDs autosomal dominant nonsyndromic deafness 72 DOID:0080268 OMIM:617606

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

3
Gene trapped

6
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display decreased body weight, reduced colon length, and impaired intestinal thiamine pyrophosphate absorption. Mice homozygous for a second null allele display increased circulating bilirubin and glucose levels and decreased prepulse inhibition.

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All GO Annotations

38
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

598
Tissues

1
cDNA Data

76
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc44a4

ZFIN slc44a4

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All Sequences

42
RefSeq

4
UniProt

4
CCDS

CCDS37591.1

Ensembl

ENSMUSG00000007034 (Evidence)
NCBI Gene

70129

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007034	Ensembl Gene Model \| MGI Sequence Detail	15971	C57BL/6J	± kb
transcript	ENSMUST00000007249	Ensembl \| MGI Sequence Detail	2261	Not Applicable
polypeptide	ENSMUSP00000007249	Ensembl \| MGI Sequence Detail	707	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015146 choline transporter-like protein 4

(term hierarchy)
InterPro Domains

IPR007603 Choline transporter-like
GlyGen

Q91VA1 10 sites, 3 N-linked glycans (4 sites)

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All nucleic 77

cDNA 76

Primer pair 1

Microarray probesets 2

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 14
Earliest

J:63110 Allcock RJ, et al., The mouse as a model for the effects of MHC genes on human disease. Immunol Today. 2000 Jul;21(7):328-32
Latest

J:351314 Sabui S, et al., Effect of knocking out mouse Slc44a4 on colonic uptake of the microbiota-generated thiamine pyrophosphate and colon physiology. Am J Physiol Gastrointest Liver Physiol. 2024 Jul 1;327(1):G36-G46

TSS for Slc44a4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144137	Chr17:35133221-35133252 (+)	-205 bp
Tssr144138	Chr17:35133408-35133422 (+)	-27 bp
Tssr144139	Chr17:35133435-35133452 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24