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Oxsr1
Gene Detail
Symbol

Name
ID
Oxsr1
oxidative-stress responsive 1
MGI:1917378
Synonyms
2210022N24Rik, 2810422B09Rik, Osr1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:119238432-119322427 bp, - strand
From VEGA annotation of GRCm38

  83996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31288  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: OXSR1
Gene Tree: Oxsr1

Human
homologs
OXSR1, oxidative stress responsive 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9943
neXtProt AC: NX_O95747

Human Synonyms: OSR1

Human Chr (Location): 3p22.2; chr3:38165260-38255488 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(51) : Gene trapped(48) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele are embryonic lethal.
 
Interactions
Oxsr1 interacts with 371 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process activation of protein kinase activity, cellular hypotonic response, ...
Component cytoplasm, extracellular exosome, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (23)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
Western blot 19
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase stk39    NEW 
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000030092 (Evidence)
Ensembl Gene Model ENSMUSG00000036737 (Evidence)
Entrez Gene 108737 (Evidence)
DFCI TC1582652, TC1597962, TC1753877, TC1608371
DoTS DT.94336216, DT.490964
NIA Mouse Gene Index U031426
EC 2.7.11.1
Consensus CDS Project CCDS57714.1
International Mouse Phenotyping Consortium Status Oxsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030092 VEGA Gene Model | MGI Sequence Detail 83996 C57BL/6J ±  kb
transcript OTTMUST00000074550 VEGA | MGI Sequence Detail 4647 Not Applicable 
polypeptide OTTMUSP00000038878 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(9) UniProt(4)
Polymorphisms
SNPs within 2kb(745 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology PR:000012099 serine/threonine-protein kinase OSR1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219977 Terker AS, et al., Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride. Cell Metab. 2015 Jan 6;21(1):39-50
All references(51)
Other
accession IDs
MGI:1919422, MGI:2143065, MGI:2143297

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory