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Oxsr1
Gene Detail
 Symbol
Name
ID
Oxsr1
oxidative-stress responsive 1
MGI:1917378
Synonyms 2210022N24Rik, 2810422B09Rik, Osr1
Feature Type protein coding gene
Genetic Map
Chromosome 9
71.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:119238432-119322427 bp, - strand
From VEGA annotation of GRCm38

  83996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31288  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Oxsr1

Human
homologs
Human Homolog OXSR1, oxidative stress responsive 1
NCBI Gene ID 9943
neXtProt AC  NX_O95747
Human Synonyms  OSR1
Human Chr (Location)  3p22.2; chr3:38165531-38255488 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(51) : Gene trapped(48) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele are embryonic lethal.
 
Interactions
Oxsr1 interacts with 371 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular hypotonic response, intracellular signal transduction, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (23)    Tissues (2)   
Theiler Stages: 28
Assay TypeResults
Immunohistochemistry 4
Western blot 19
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030092 (Evidence)
Ensembl Gene ModelENSMUSG00000036737 (Evidence)
Entrez Gene108737 (Evidence)
DFCITC1582652, TC1597962, TC1608371, TC1753877
DoTSDT.490964, DT.94336216
NIA Mouse Gene IndexU031426
EC2.7.11.1
Consensus CDS ProjectCCDS57714.1
International Mouse Knockout Project StatusOxsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030092 VEGA Gene Model | MGI Sequence Detail 83996 C57BL/6J ±  kb
transcript OTTMUST00000074550 VEGA | MGI Sequence Detail 4647 Not Applicable 
polypeptide OTTMUSP00000038878 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(7) UniProt(4)
Polymorphisms SNPs within 2kb(745 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology PR:000012099 serine/threonine-protein kinase OSR1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211319 de Los Heros P, et al., The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. Biochem J. 2014 Mar 15;458(3):559-73
All references(52)
Other
accession IDs
MGI:1919422, MGI:2143065, MGI:2143297

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory