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Mllt3
Gene Detail
Symbol

Name
ID
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MGI:1917372
Synonyms
2210011H10Rik, 2610012I03Rik, 3830408D16Rik, Af9, D4Ertd321e
Feature Type
protein coding gene
Genetic Map
Chromosome 4
41.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:87769925-88033364 bp, - strand
From VEGA annotation of GRCm38

  263440 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37933  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: MLLT3
Protein SuperFamily: MLLT
Gene Tree: Mllt3

Human
homologs
MLLT3, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4300
neXtProt AC: NX_P42568

Human Synonyms: AF9, YEATS3

Human Chr (Location): 9p22; chr9:20341665-20622543 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(3) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
About 50% of homozygous null mice die perinatally while the remaining 50% become runted and die within two weeks of birth with severe defects of the axial skeleton, including anterior homeotic transformation of the cervical and thoracic regions, a deformed atlas and an extra cervical vertebra.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Mllt3 interacts with 446 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process anterior/posterior pattern specification, negative regulation of canonical Wnt signaling pathway, ...
Component extracellular exosome, nucleus, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (409)    Tissues (130)    Images (95)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 306
In situ reporter (knock in) 91
RT-PCR 12
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MLLT3 ; Xenbase mllt3 ; ZFIN mllt3    NEW 
Molecular
reagents
All nucleic(22) cDNA(20) Primer pair(2)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000007699 (Evidence)
Ensembl Gene Model ENSMUSG00000028496 (Evidence)
Entrez Gene 70122 (Evidence)
DFCI TC1684653, TC1588740, TC1578398, TC1682215, TC1601354, TC1648671, TC1640878, TC1609892, TC1626375
DoTS DT.94397709, DT.91336985, DT.91306202, DT.524772, DT.101376146, DT.480707, DT.101367706, DT.94397710
NIA Mouse Gene Index U025239
Consensus CDS Project CCDS38796.1, CCDS38797.1, CCDS71418.1
International Mouse Phenotyping Consortium Status Mllt3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007699 VEGA Gene Model | MGI Sequence Detail 263440 C57BL/6J ±  kb
transcript OTTMUST00000017631 VEGA | MGI Sequence Detail 6069 Not Applicable 
polypeptide OTTMUSP00000008140 VEGA | MGI Sequence Detail 569 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(14) UniProt(7)
Polymorphisms
SNPs within 2kb(1446 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005033 YEATS
Protein Ontology PR:000010452 protein AF-9
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(50)
Other
accession IDs
MGI:1196448, MGI:1919694, MGI:1924826

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory