Yars2
Gene Detail

Symbol Name ID

Yars2 tyrosyl-tRNA synthetase 2 (mitochondrial) MGI:1917370

Synonyms

2210023C10Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 16

10.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:16302965-16309640 bp, + strand From VEGA annotation of GRCm38   6676 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7097  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Yars2

Human homologs

Human Homolog		YARS2, tyrosyl-tRNA synthetase 2, mitochondrial
NCBI Gene ID		51067
neXtProt AC		NX_Q9Y2Z4
Human Synonyms		MLASA2, MT-TYRRS, TYRRS
Human Chr (Location)		12p11.21; chr12:32899478-32908887 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human YARS2

Alleles and phenotypes

All alleles(10) : Targeted(2) Gene trapped(8)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	mitochondrial tyrosyl-tRNA aminoacylation, translation, ...
Component	cytoplasm, mitochondrion
Function	aminoacyl-tRNA ligase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (156)    Tissues (103)    Images (23)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	156

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) cDNA(35)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026531 (Evidence)
Ensembl Gene Model	ENSMUSG00000022792 (Evidence)
Entrez Gene	70120 (Evidence)
UniGene	37486
DFCI	TC1578616, TC1588511
DoTS	DT.101362235, DT.110732284, DT.40136575, DT.485757, DT.94245366
NIA Mouse Gene Index	U016854
EC	6.1.1.1
Consensus CDS Project	CCDS27983.1
International Mouse Knockout Project Status	Yars2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026531	VEGA Gene Model | MGI Sequence Detail	6676	C57BL/6J
transcript	OTTMUST00000065640	VEGA | MGI Sequence Detail	1574	Not Applicable
polypeptide	OTTMUSP00000032741	VEGA | MGI Sequence Detail	472	Not Applicable

All sequences(50) RefSeq(3) UniProt(5)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002305	Aminoacyl-tRNA synthetase, class Ic
InterPro	IPR001412	Aminoacyl-tRNA synthetase, class I, conserved site
InterPro	IPR002942	RNA-binding S4 domain
InterPro	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
InterPro	IPR002307	Tyrosine-tRNA ligase
InterPro	IPR024088	Tyrosine-tRNA ligase, bacterial-type
Protein Ontology	PR:000017524	tyrosyl-tRNA synthetase, mitochondrial

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(32)

Other accession IDs

MGI:2146633