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Yars2 Gene Detail
Summary
  • Symbol
    Yars2
  • Name
    tyrosyl-tRNA synthetase 2 (mitochondrial)
  • Synonyms
    2210023C10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917370
    NCBI Gene: 70120
Location & Maps
more
  • Sequence Map
    Chr16:16302965-16309640 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6676 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    YARS2, tyrosyl-tRNA synthetase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    YARS2, tyrosyl-tRNA synthetase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CGI-04, MLASA2, MT-TYRRS, TYRRS
  • Links
    NCBI Gene ID: 51067
    neXtProt AC: NX_Q9Y2Z4

  • Chr Location
    12p11.21; chr12:32725091-32755961 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7097
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: YARS2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human YARS2 associations

Human Disease Mouse Models
       Myopathy, Lactic Acidosis, and Sideroblastic Anemia 2; MLASA2   OMIM: 613561
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026531 VEGA Gene Model | MGI Sequence Detail 6676 C57BL/6J ±  kb
transcript OTTMUST00000065640 VEGA | MGI Sequence Detail 1574 Not Applicable  
polypeptide OTTMUSP00000032741 VEGA | MGI Sequence Detail 472 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    21 from dbSNP Build 137
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000017524 tyrosine--tRNA ligase, mitochondrial
  • EC
  • InterPro Domains
    IPR002305 Aminoacyl-tRNA synthetase, class Ic
    IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
    IPR002942 RNA-binding S4 domain
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR002307 Tyrosine-tRNA ligase
    IPR024088 Tyrosine-tRNA ligase, bacterial-type
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146633
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory