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Ifi35 Gene Detail
Summary
  • Symbol
    Ifi35
  • Name
    interferon-induced protein 35
  • Synonyms
    2010008K16Rik, IFP35
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917360
    NCBI Gene: 70110
  • Gene Overview
    MyGene.info: IFI35
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101339238-101349527 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 65.07 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917360
protein coding gene Chr11:101339233-101349527 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019203
protein coding gene Chr11:104315936-104326725 (+)
A/J MGP_AJ_G0019171
protein coding gene Chr11:99930226-99940526 (+)
AKR/J MGP_AKRJ_G0019140
protein coding gene Chr11:103036744-103047031 (+)
BALB/cJ MGP_BALBcJ_G0019145
protein coding gene Chr11:100422709-100432986 (+)
C3H/HeJ MGP_C3HHeJ_G0018954
protein coding gene Chr11:103211524-103223585 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019594
protein coding gene Chr11:107591139-107601379 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017220
protein coding gene Chr11:97327228-97338308 (+)
CAST/EiJ MGP_CASTEiJ_G0018508
protein coding gene Chr11:104191906-104202266 (+)
CBA/J MGP_CBAJ_G0018923
protein coding gene Chr11:112018497-112029933 (+)
DBA/2J MGP_DBA2J_G0019035
protein coding gene Chr11:99451702-99462546 (+)
FVB/NJ MGP_FVBNJ_G0019025
protein coding gene Chr11:98994933-99004890 (+)
LP/J MGP_LPJ_G0019104
protein coding gene Chr11:104856002-104866304 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019056
protein coding gene Chr11:111575665-111585865 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019632
protein coding gene Chr11:103366471-103376658 (+)
PWK/PhJ MGP_PWKPhJ_G0018271
protein coding gene Chr11:100513947-100524801 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018063
protein coding gene Chr11:103088788-103100031 (+)
WSB/EiJ MGP_WSBEiJ_G0018557
protein coding gene Chr11:103361716-103371977 (+)



Homology
more
  • Human Ortholog
    IFI35, interferon induced protein 35
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFI35, interferon induced protein 35
  • Synonyms
    IFP35
  • Links
    NCBI Gene ID: 3430
    neXtProt AC: NX_P80217
    UniProt: P80217

  • Chr Location
    17q21.31; chr17:43006725-43014459 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a different null allele exhibit reduced susceptibility to LPS treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70110 NCBI Gene Model | MGI Sequence Detail 10290 C57BL/6J ±  kb
    transcript NM_027320 RefSeq | MGI Sequence Detail 1360 C57BL/6  
    polypeptide Q9D8C4 UniProt | EBI | MGI Sequence Detail 286 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 75

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144592
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:309551 Jing X, et al., IFP35 family proteins promote neuroinflammation and multiple sclerosis. Proc Natl Acad Sci U S A. 2021 Aug 10;118(32)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/19/2021
    MGI 6.17
    The Jackson Laboratory