Dnmbp MGI Mouse Gene Detail - MGI:1917352

Symbol

Dnmbp
Name

dynamin binding protein
Synonyms

2410003L07Rik, 2410003M15Rik, Tuba

Feature Type

protein coding gene
IDs

MGI:1917352
NCBI Gene: 71972
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr19:43835260-43928630 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 36.67 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

735 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917352	protein coding gene	Chr19:43835259-43930930 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025159	protein coding gene	Chr19:43275832-43376840 (-)
A/J	MGP_AJ_G0025136	protein coding gene	Chr19:41218482-41293537 (-)
AKR/J	MGP_AKRJ_G0025104	protein coding gene	Chr19:42512572-42577132 (-)
BALB/cJ	MGP_BALBcJ_G0025130	protein coding gene	Chr19:41264030-41357365 (-)
C3H/HeJ	MGP_C3HHeJ_G0024890	protein coding gene	Chr19:42694955-42790471 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025573	protein coding gene	Chr19:44343924-44411409 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022987	protein coding gene	Chr19:40511391-40607573 (-)
CAST/EiJ	MGP_CASTEiJ_G0024355	protein coding gene	Chr19:42388310-42496210 (-)
CBA/J	MGP_CBAJ_G0024870	protein coding gene	Chr19:46544388-46649191 (-)
DBA/2J	MGP_DBA2J_G0025002	protein coding gene	Chr19:41044935-41138138 (-)
FVB/NJ	MGP_FVBNJ_G0024963	protein coding gene	Chr19:40794958-40869261 (-)
LP/J	MGP_LPJ_G0025088	protein coding gene	Chr19:43241542-43318529 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024994	protein coding gene	Chr19:46081156-46158931 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025631	protein coding gene	Chr19:42608815-42685108 (-)
PWK/PhJ	MGP_PWKPhJ_G0024104	protein coding gene	Chr19:40938688-41034545 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023908	protein coding gene	Chr19:41327186-41391408 (-)
WSB/EiJ	MGP_WSBEiJ_G0024425	protein coding gene	Chr19:42746170-42841440 (-)

Human Ortholog

DNMBP, dynamin binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNMBP, dynamin binding protein
Synonyms

ARHGEF36, CTRCT48, TUBA
Links

HGNC:30373

NCBI Gene ID: 23268

neXtProt AC: NX_Q6XZF7

UniProt: Q6XZF7
Chr Location

10q24.2; chr10:99875571-100009947 (-) GRCh38

MGI Vertebrate Homology

Dnmbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNMBP
Gene Tree

Dnmbp

Diseases

1 with human DNMBP associations

				Human Disease	Mouse Models
				cataract 48 IDs cataract 48 DOID:0070354 OMIM:618415

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Endonuclease-mediated

2
Gene trapped

33
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

69 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

11
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DNMBP

Xenbase dnmbp

ZFIN dnmbp

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All Sequences

75
RefSeq

20
UniProt

6
CCDS

CCDS29839.1, CCDS84442.1

Ensembl

ENSMUSG00000025195 (Evidence)
NCBI Gene

71972

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025195	Ensembl Gene Model \| MGI Sequence Detail	93371	C57BL/6J	± kb
transcript	ENSMUST00000212396	Ensembl \| MGI Sequence Detail	6100	Not Applicable
polypeptide	ENSMUSP00000148582	Ensembl \| MGI Sequence Detail	1580	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006605 dynamin-binding protein

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR004148 BAR domain

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR035820 Dynamin-binding protein, first C-terminal SH3 domain

IPR035817 Dynamin-binding protein, first N-terminal SH3 domain

IPR035818 Dynamin-binding protein, second N-terminal SH3 domain

IPR035819 Dynamin-binding protein, third N-terminal SH3 domain

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 18

Genomic 2

cDNA 14

Primer pair 2

Microarray probesets 5

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MGI:1919222

Summaries

All 40

Developmental Gene Expression 6

Gene Ontology 7

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:330827 Yoo D, et al., Little skate genome provides insights into genetic programs essential for limb-based locomotion. Elife. 2022 Oct 26;11:e78345

TSS for Dnmbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159402	Chr19:43928642-43928671 (-)	-27 bp
Tssr159401	Chr19:43928607-43928638 (-)	7 bp
Tssr159400	Chr19:43928585-43928604 (-)	35 bp
Tssr159399	Chr19:43909849-43909858 (-)	18,776 bp
Tssr159398	Chr19:43879031-43879049 (-)	49,590 bp
Tssr159397	Chr19:43879014-43879025 (-)	49,610 bp
Tssr159396	Chr19:43878994-43879005 (-)	49,630 bp
Tssr159395	Chr19:43868211-43868241 (-)	60,404 bp
Tssr159394	Chr19:43868150-43868168 (-)	60,471 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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