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Sash1 Gene Detail
Summary
  • Symbol
    Sash1
  • Name
    SAM and SH3 domain containing 1
  • Synonyms
    1100001C18Rik, 2500002E12Rik, A330076K04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917347
    NCBI Gene: 70097
  • Gene Overview
    MyGene.info: SASH1
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:8722219-8886070 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 2.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1676 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917347
protein coding gene Chr10:8722217-9027745 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017004
protein coding gene Chr10:5995766-6170353 (-)
A/J MGP_AJ_G0016982
protein coding gene Chr10:5696083-5864878 (-)
AKR/J MGP_AKRJ_G0016946
protein coding gene Chr10:5802643-5982208 (-)
BALB/cJ MGP_BALBcJ_G0016940
protein coding gene Chr10:5641826-5813961 (-)
C3H/HeJ MGP_C3HHeJ_G0016765
protein coding gene Chr10:5965472-6141947 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017402
protein coding gene Chr10:6119790-6294797 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015107
protein coding gene Chr10:5226529-5390112 (-)
CAST/EiJ MGP_CASTEiJ_G0016347
protein coding gene Chr10:5835309-6010454 (-)
CBA/J MGP_CBAJ_G0016737
protein coding gene Chr10:6332819-6523979 (-)
DBA/2J MGP_DBA2J_G0016845
protein coding gene Chr10:5614149-5778898 (-)
FVB/NJ MGP_FVBNJ_G0016840
protein coding gene Chr10:5560402-5726115 (-)
LP/J MGP_LPJ_G0016920
protein coding gene Chr10:5804574-5970451 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016870
protein coding gene Chr10:6252092-6423826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017440
protein coding gene Chr10:5771600-5942065 (-)
PWK/PhJ MGP_PWKPhJ_G0016132
protein coding gene Chr10:5569141-5735697 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015914
protein coding gene Chr10:5845726-6025346 (-)
WSB/EiJ MGP_WSBEiJ_G0016409
protein coding gene Chr10:5770564-5941208 (-)



Homology
more
  • Human Ortholog
    SASH1, SAM and SH3 domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SASH1, SAM and SH3 domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ323M4.1, SH3D6A
  • Links
    NCBI Gene ID: 23328
    neXtProt AC: NX_O94885
    UniProt: O94885

  • Chr Location
    6q24.3-q25.1; chr6:148193440-148552049 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69182
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SASH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015305 Ensembl Gene Model | MGI Sequence Detail 163852 C57BL/6J ±  kb
transcript ENSMUST00000015449 Ensembl | MGI Sequence Detail 7183 Not Applicable  
polypeptide ENSMUSP00000015449 Ensembl | MGI Sequence Detail 1230 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 55

    Microarray probesets 2
Other
Accession IDs
less
MGI:1915682, MGI:2444711
References
more
  • Summaries
    All 27
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:205449 Dauphinee SM, et al., SASH1 is a scaffold molecule in endothelial TLR4 signaling. J Immunol. 2013 Jul 15;191(2):892-901

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory