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Cysltr2 Gene Detail
Summary
  • Symbol
    Cysltr2
  • Name
    cysteinyl leukotriene receptor 2
  • Synonyms
    2300001H05Rik, Cyslt2, CysLT2, CYSLT2R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917336
    NCBI Gene: 70086
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:73025772-73049114 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 38.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    272 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917336
protein coding gene Chr14:73025603-73049114 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021553
protein coding gene Chr14:67768494-67790239 (-)
A/J MGP_AJ_G0021512
protein coding gene Chr14:66283144-66303120 (-)
AKR/J MGP_AKRJ_G0021488
protein coding gene Chr14:68237218-68257162 (-)
BALB/cJ MGP_BALBcJ_G0021518
protein coding gene Chr14:66047533-66067509 (-)
C3H/HeJ MGP_C3HHeJ_G0021295
protein coding gene Chr14:67962070-67982049 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021959
protein coding gene Chr14:70737626-70757612 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019497
protein coding gene Chr14:64005321-64025897 (-)
CAST/EiJ MGP_CASTEiJ_G0020813
protein coding gene Chr14:64610986-64630959 (-)
CBA/J MGP_CBAJ_G0021263
protein coding gene Chr14:72961857-72981840 (-)
DBA/2J MGP_DBA2J_G0021386
protein coding gene Chr14:65668268-65688241 (-)
FVB/NJ MGP_FVBNJ_G0021364
protein coding gene Chr14:65051702-65071664 (-)
LP/J MGP_LPJ_G0021456
protein coding gene Chr14:68942695-68962755 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021393
protein coding gene Chr14:71812725-71833659 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021981
protein coding gene Chr14:67502020-67522006 (-)
PWK/PhJ MGP_PWKPhJ_G0020556
protein coding gene Chr14:62435647-62455785 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020391
protein coding gene Chr14:63477417-63497265 (-)
WSB/EiJ MGP_WSBEiJ_G0020866
protein coding gene Chr14:67856641-67876677 (-)



Homology
more
  • Human Ortholog
    CYSLTR2, cysteinyl leukotriene receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYSLTR2, cysteinyl leukotriene receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CYSLT2, CYSLT2R, GPCR21, HG57, hGPCR21, HPN321, KPG_011, PSEC0146
  • Links
    NCBI Gene ID: 57105
    neXtProt AC: NX_Q9NS75
    UniProt: Q9NS75

  • Chr Location
    13q14.2; chr13:48653711-48709362 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced bleomycin-induced pulmonary fibrosis and reduced IgE dependent passive cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70086 NCBI Gene Model | MGI Sequence Detail 23343 C57BL/6J ±  kb
transcript NM_133720 RefSeq | MGI Sequence Detail 1802 C57BL/6  
polypeptide Q920A1 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:258129 Liu T, et al., Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. J Immunol. 2018 Feb 1;200(3):915-927

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory