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Cysltr2 Gene Detail
Summary
  • Symbol
    Cysltr2
  • Name
    cysteinyl leukotriene receptor 2
  • Synonyms
    2300001H05Rik, Cyslt2, CysLT2, CYSLT2R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917336
    NCBI Gene: 70086
Location & Maps
more
  • Sequence Map
    Chr14:73029128-73049114 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19987 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 38.54 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CYSLTR2, cysteinyl leukotriene receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CYSLTR2, cysteinyl leukotriene receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYSLT2, CYSLT2R, GPCR21, HG57, hGPCR21, HPN321, KPG_011, PSEC0146
  • Links
    NCBI Gene ID: 57105
    neXtProt AC: NX_Q9NS75

  • Chr Location
    13q14.2; chr13:48706815-48709362 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    1 involving Cysltr2
Homozygous null mice display reduced bleomycin-induced pulmonary fibrosis and reduced IgE dependent passive cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033470 Ensembl Gene Model | MGI Sequence Detail 19987 C57BL/6J ±  kb
transcript ENSMUST00000044664 Ensembl | MGI Sequence Detail 1802 Not Applicable  
polypeptide ENSMUSP00000040715 Ensembl | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    238 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001219 cysteinyl leukotriene receptor 2
  • InterPro Domains
    IPR004071 Cysteinyl leukotriene receptor
    IPR013311 Cysteinyl leukotriene receptor 2
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 7
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:210862 Kawakami Y, et al., Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies. Biochim Biophys Acta. 2014 Jun;1840(6):1625-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory