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Degs2 Gene Detail
Summary
  • Symbol
    Degs2
  • Name
    delta(4)-desaturase, sphingolipid 2
  • Synonyms
    2210008A03Rik, Des2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917309
    NCBI Gene: 70059
  • Gene Overview
    MyGene.info: DEGS2
Location & Maps
more
  • Sequence Map
    Chr12:108686792-108702306 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15515 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 59.46 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DEGS2, delta(4)-desaturase, sphingolipid 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DEGS2, delta(4)-desaturase, sphingolipid 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C14orf66, DES2, FADS8
  • Links
    NCBI Gene ID: 123099
    neXtProt AC: NX_Q6QHC5

  • Chr Location
    14q32.2; chr14:100146416-100166882 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70059 NCBI Gene Model | MGI Sequence Detail 15515 C57BL/6J ±  kb
transcript NM_001171002 RefSeq | MGI Sequence Detail 3185 C57BL/6  
polypeptide Q8R2F2 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    96 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006414 sphingolipid delta(4)-desaturase/C4-hydroxylase DES2
  • EC
  • InterPro Domains
    IPR005804 Fatty acid desaturase domain
    IPR011388 Sphingolipid delta4-desaturase
    IPR031195 Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2
    IPR013866 Sphingolipid delta4-desaturase, N-terminal
Molecular
Reagents
less
  • All nucleic 45
    cDNA 45

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144905
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:216600 Lau CG, et al., Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory