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Prpf4 Gene Detail
Summary
  • Symbol
    Prpf4
  • Name
    pre-mRNA processing factor 4
  • Synonyms
    1600015H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917302
    NCBI Gene: 70052
  • Gene Overview
    MyGene.info: PRPF4
Location & Maps
more
  • Sequence Map
    Chr4:62408797-62426990 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18194 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 33.13 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRPF4, pre-mRNA processing factor 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRPF4, pre-mRNA processing factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60
  • Links
    NCBI Gene ID: 9128
    neXtProt AC: NX_O43172

  • Chr Location
    9q31-q33; chr9:113275634-113293914 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3446
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PRPF4
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PRPF4 associations

Human Disease Mouse Models
       Retinitis Pigmentosa 70; RP70   OMIM: 615922
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase prpf4
    ZFIN prpf4
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000234 VEGA Gene Model | MGI Sequence Detail 18194 C57BL/6J ±  kb
transcript OTTMUST00000000683 VEGA | MGI Sequence Detail 5223 Not Applicable  
polypeptide OTTMUSP00000000303 VEGA | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013283 U4/U6 small nuclear ribonucleoprotein Prp4
  • InterPro Domains
    IPR020472 G-protein beta WD-40 repeat
    IPR014906 Pre-mRNA processing factor 4 (PRP4)-like
    IPR027106 U4/U6 small nuclear ribonucleoprotein Prp4
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 73
    cDNA 73

    Microarray probesets 7
Other
Accession IDs
less
MGI:2140401, MGI:2140542
References
more
  • Summaries
    All 31
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory