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Acot7 Gene Detail
Summary
  • Symbol
    Acot7
  • Name
    acyl-CoA thioesterase 7
  • Synonyms
    2410041A17Rik, AU014716, Bach
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917275
    NCBI Gene: 70025
  • Gene Overview
    MyGene.info: ACOT7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:152178134-152271852 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      93719 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 82.93 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACOT7, acyl-CoA thioesterase 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACOT7, acyl-CoA thioesterase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACH1, ACT, BACH, CTE-II, hBACH, LACH, LACH1
  • Links
    NCBI Gene ID: 11332
    neXtProt AC: NX_O00154
    UniProt: O00154

  • Chr Location
    1p36.31; chr1:6264272-6393766 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele activated in neurons exhibit abnormal glucose and lipid homeostasis, altered metabolism, increaased adiposity, decreased lean mass, progressive neurodegeneration, and neurological defects in aged mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010306 VEGA Gene Model | MGI Sequence Detail 93719 C57BL/6J ±  kb
    transcript OTTMUST00000024016 VEGA | MGI Sequence Detail 1425 Not Applicable  
    polypeptide OTTMUSP00000011019 VEGA | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      404 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 108
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140421, MGI:2140425, MGI:2140481, MGI:2140603
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:243411 Rutledge EA, et al., Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory