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Acot7 Gene Detail
Summary
  • Symbol
    Acot7
  • Name
    acyl-CoA thioesterase 7
  • Synonyms
    2410041A17Rik, AU014716, Bach
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917275
    NCBI Gene: 70025
  • Gene Overview
    MyGene.info: ACOT7
Location & Maps
more
  • Sequence Map
    Chr4:152178134-152271852 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      93719 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 82.93 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACOT7, acyl-CoA thioesterase 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACOT7, acyl-CoA thioesterase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACH1, ACT, BACH, CTE-II, hBACH, LACH, LACH1
  • Links
    NCBI Gene ID: 11332
    neXtProt AC: NX_O00154

  • Chr Location
    1p36; chr1:6264272-6393766 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    87
  • Gene trapped
    81
  • Targeted
    6
  • Genomic Mutations
    3 involving Acot7
  • Incidental Mutations
    APF
Mice homozygous for a floxed allele activated in neurons exhibit abnormal glucose and lipid homeostasis, altered metabolism, increaased adiposity, decreased lean mass, progressive neurodegeneration, and neurological defects in aged mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010306 VEGA Gene Model | MGI Sequence Detail 93719 C57BL/6J ±  kb
transcript OTTMUST00000024016 VEGA | MGI Sequence Detail 1425 Not Applicable  
polypeptide OTTMUSP00000011019 VEGA | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    404 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 108
    cDNA 107
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2140421, MGI:2140425, MGI:2140481, MGI:2140603
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory