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Mcm10 Gene Detail
Summary
  • Symbol
    Mcm10
  • Name
    minichromosome maintenance 10 replication initiation factor
  • Synonyms
    2410041F14Rik, C330019M07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917274
    NCBI Gene: 70024
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:4995535-5017602 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 3.12 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    270 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917274
protein coding gene Chr2:4994525-5017602 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025319
protein coding gene Chr2:2079483-2101913 (-)
A/J MGP_AJ_G0025296
protein coding gene Chr2:1970416-1994642 (-)
AKR/J MGP_AKRJ_G0025264
protein coding gene Chr2:2009693-2035564 (-)
BALB/cJ MGP_BALBcJ_G0025292
protein coding gene Chr2:1955658-1978042 (-)
C3H/HeJ MGP_C3HHeJ_G0025052
protein coding gene Chr2:2004613-2027168 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025734
protein coding gene Chr2:2097311-2120870 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023148
protein coding gene Chr2:1821220-1844999 (-)
CAST/EiJ MGP_CASTEiJ_G0024515
protein coding gene Chr2:2028463-2050713 (-)
CBA/J MGP_CBAJ_G0025031
protein coding gene Chr2:2190750-2215174 (-)
DBA/2J MGP_DBA2J_G0025163
protein coding gene Chr2:1940923-1963624 (-)
FVB/NJ MGP_FVBNJ_G0025125
protein coding gene Chr2:1933307-1956955 (-)
LP/J MGP_LPJ_G0025249
protein coding gene Chr2:2059028-2082677 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025157
protein coding gene Chr2:2080958-2105024 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025792
protein coding gene Chr2:2011376-2034724 (-)
PWK/PhJ MGP_PWKPhJ_G0024266
protein coding gene Chr2:1921465-1944373 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024066
protein coding gene Chr2:1999898-2022502 (-)
WSB/EiJ MGP_WSBEiJ_G0024585
protein coding gene Chr2:2034889-2060053 (-)



Homology
more
  • Human Ortholog
    MCM10, minichromosome maintenance 10 replication initiation factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCM10, minichromosome maintenance 10 replication initiation factor
  • Synonyms
    CNA43, DNA43, IMD80, PRO2249
  • Links
    NCBI Gene ID: 55388
    neXtProt AC: NX_Q7L590
    UniProt: Q7L590

  • Chr Location
    10p13; chr10:13161558-13211110 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human MCM10 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced embryonic cell proliferation and early embryonic letahlity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70024 NCBI Gene Model | MGI Sequence Detail 22068 C57BL/6J ±  kb
    transcript NM_001305259 RefSeq | MGI Sequence Detail 3879 C57BL/6  
    polypeptide Q0VBD2 UniProt | EBI | MGI Sequence Detail 885 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925780, MGI:2139167, MGI:2139484
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory