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Ddi2 Gene Detail
Summary
  • Symbol
    Ddi2
  • Name
    DNA-damage inducible protein 2
  • Synonyms
    1110056G13Rik, 1700027M01Rik, 9130022E05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917244
    NCBI Gene: 68817
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141683563-141723419 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 74.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    452 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917244
protein coding gene Chr4:141677549-141723419 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029054
protein coding gene Chr4:144767619-144814889 (-)
A/J MGP_AJ_G0029014
protein coding gene Chr4:138454449-138501093 (-)
AKR/J MGP_AKRJ_G0028966
protein coding gene Chr4:142480305-142534238 (-)
BALB/cJ MGP_BALBcJ_G0029038
protein coding gene Chr4:139152338-139199096 (-)
C3H/HeJ MGP_C3HHeJ_G0028752
protein coding gene Chr4:142843330-142892382 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029479
protein coding gene Chr4:149807421-149854250 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026750
protein coding gene Chr4:131369324-131414002 (-)
CAST/EiJ MGP_CASTEiJ_G0028184
protein coding gene Chr4:141112861-141158624 (-)
CBA/J MGP_CBAJ_G0028716
protein coding gene Chr4:154222137-154275372 (-)
DBA/2J MGP_DBA2J_G0028866
protein coding gene Chr4:138850304-138897022 (-)
FVB/NJ MGP_FVBNJ_G0028833
protein coding gene Chr4:137971849-138017794 (-)
LP/J MGP_LPJ_G0028965
protein coding gene Chr4:144785397-144830984 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028859
protein coding gene Chr4:157959368-158006415 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029517
protein coding gene Chr4:142996134-143044080 (-)
PWK/PhJ MGP_PWKPhJ_G0027905
protein coding gene Chr4:135744965-135791780 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027729
protein coding gene Chr4:138807039-138853304 (-)
WSB/EiJ MGP_WSBEiJ_G0028262
protein coding gene Chr4:143267600-143313522 (-)



Homology
more
  • Human Ortholog
    DDI2, DNA damage inducible 1 homolog 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDI2, DNA damage inducible 1 homolog 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 84301
    neXtProt AC: NX_Q5TDH0
    UniProt: Q5TDH0

  • Chr Location
    1p36.21; chr1:15617458-15661057 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 121661
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DDI2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68817 NCBI Gene Model | MGI Sequence Detail 39857 C57BL/6J ±  kb
transcript NM_001017966 RefSeq | MGI Sequence Detail 3539 C57BL/6  
polypeptide A2ADY9 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916067, MGI:1921816, MGI:2140343, MGI:2140476
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:261900 Ramirez J, et al., Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome. Hum Mol Genet. 2018 Jun 1;27(11):1955-1971

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory