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Chn2
Gene Detail
Symbol

Name
ID
Chn2
chimerin 2
MGI:1917243
Synonyms
1700026N20Rik, 4930557O16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 6
26.54 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:54039554-54301810 bp, + strand
From VEGA annotation of GRCm38

  262257 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31213  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: chimaerin
Gene Tree: Chn2

Human
homologs
Human Homolog CHN2, chimerin 2
NCBI Gene ID 1124
neXtProt AC  NX_P52757
Human Synonyms  ARHGAP3, BCH, CHN2-3, RHOGAP3
Human Chr (Location)  7p15.3; chr7:29194505-29514328 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(33) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele exhibit impaired infrapyramidal tract neuron prunning.
 
Interactions
Chn2 interacts with 284 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process intracellular signal transduction, positive regulation of GTPase activity, ...
Component intracellular, membrane, ...
Function GTPase activator activity, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (38)    Tissues (25)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 38
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000023143 (Evidence)
Ensembl Gene ModelENSMUSG00000004633 (Evidence)
Entrez Gene69993 (Evidence)
DFCITC1617451, TC1589556, TC1578195
DoTSDT.97369319, DT.97363182, DT.94122783, DT.101362928, DT.91335241, DT.87043711, DT.110483865, DT.487164
NIA Mouse Gene IndexU006885
Consensus CDS ProjectCCDS20154.1, CCDS51778.1
International Mouse Knockout Project StatusChn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023143 VEGA Gene Model | MGI Sequence Detail 262257 C57BL/6J ±  kb
transcript OTTMUST00000055937 VEGA | MGI Sequence Detail 2418 Not Applicable 
polypeptide OTTMUSP00000026841 VEGA | MGI Sequence Detail 468 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(10) UniProt(13)
Polymorphisms
SNPs within 2kb(2324 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017356 N-chimaerin
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR000980 SH2 domain
Protein Ontology PR:000005443 beta-chimaerin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186252 Riccomagno MM, et al., The RacGAP beta2-Chimaerin Selectively Mediates Axonal Pruning in the Hippocampus. Cell. 2012 Jun 22;149(7):1594-606
All references(38)
Other
accession IDs
MGI:1922054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory