Sis
Gene Detail

Symbol Name ID

Sis sucrase isomaltase (alpha-glucosidase) MGI:1917233

Synonyms

2010204N08Rik, Si-s, sucrase-isomaltase

Feature Type

protein coding gene

Genetic Map

Chromosome 3

32.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr3:72888557-72967863 bp, - strand From VEGA annotation of GRCm38   79307 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Sis

Human homologs

Human Homolog		SI, sucrase-isomaltase (alpha-glucosidase)
NCBI Gene ID		6476
neXtProt AC		NX_P14410
Human Chr (Location)		3q25.2-q26.2; chr3:164696686-164796283 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SI

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	metabolic process
Component	brush border, membrane, ...
Function	beta-fructofuranosidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (140)    Tissues (139)    Images (1)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	94
RT-PCR	46

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) Genomic(2) cDNA(8) Primer pair(1)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000035151 (Evidence)
Ensembl Gene Model	ENSMUSG00000027790 (Evidence)
Entrez Gene	69983 (Evidence)
UniGene	261054
DFCI	TC1628303
DoTS	DT.40146146
NIA Mouse Gene Index	U024150
EC	3.2.1.10
Consensus CDS Project	CCDS38454.1
International Mouse Knockout Project Status	Sis

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035151	VEGA Gene Model | MGI Sequence Detail	79307	C57BL/6J
transcript	OTTMUST00000089508	VEGA | MGI Sequence Detail	5953	Not Applicable
polypeptide	OTTMUSP00000048927	VEGA | MGI Sequence Detail	1818	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(190 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000322	Glycoside hydrolase, family 31
InterPro	IPR025887	Glycoside hydrolase family 31, N-terminal domain
InterPro	IPR017853	Glycoside hydrolase, superfamily
InterPro	IPR011013	Glycoside hydrolase-type carbohydrate-binding
InterPro	IPR000519	P-type trefoil
InterPro	IPR017957	P-type trefoil, conserved site
Protein Ontology	PR:000014858	sucrase-isomaltase, intestinal

References

(Earliest) J:8342 James PS, et al., Evidence for a possible regulatory gene (Suc-1) controlling sucrase expression in mouse intestine. Biochem Genet. 1986 Apr;24(3-4):169-81
(Latest) J:173543 Harper J, et al., The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10585-90
All references(53)

Other accession IDs

MGD-MRK-14410, MGI:98303