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Sis
Gene Detail
 Symbol
Name
ID
Sis
sucrase isomaltase (alpha-glucosidase)
MGI:1917233
Synonyms 2010204N08Rik, Si-s, sucrase-isomaltase
Feature Type protein coding gene
Genetic Map
Chromosome 3
32.59 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr3:72888557-72967863 bp, - strand
From VEGA annotation of GRCm38

  79307 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37424  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Sis

Human
homologs
Human Homolog SI, sucrase-isomaltase (alpha-glucosidase)
NCBI Gene ID 6476
neXtProt AC  NX_P14410
Human Chr (Location)  3q25.2-q26.2; chr3:164978898-165078495 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SI
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Sis interacts with 166 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process metabolic process
Component brush border, membrane, ...
Function beta-fructofuranosidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (147)    Tissues (141)    Images (1)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 98
RT-PCR 49
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(2) cDNA(9) Primer pair(2)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000035151 (Evidence)
Ensembl Gene ModelENSMUSG00000027790 (Evidence)
Entrez Gene69983 (Evidence)
UniGene261054
DFCITC1628303
DoTSDT.40146146
NIA Mouse Gene IndexU024150
EC3.2.1.10
Consensus CDS ProjectCCDS38454.1
International Mouse Knockout Project StatusSis
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035151 VEGA Gene Model | MGI Sequence Detail 79307 C57BL/6J ±  kb
transcript OTTMUST00000089508 VEGA | MGI Sequence Detail 5953 Not Applicable 
polypeptide OTTMUSP00000048927 VEGA | MGI Sequence Detail 1818 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(346 from dbSNP Build 137)    SNPs within 2kb including multiple locations(348)
Protein-related
information
ResourceIDDescription
InterPro IPR011013 Galactose mutarotase-like domain
InterPro IPR000322 Glycoside hydrolase, family 31
InterPro IPR025887 Glycoside hydrolase family 31, N-terminal domain
InterPro IPR017853 Glycoside hydrolase, superfamily
InterPro IPR000519 P-type trefoil
InterPro IPR017957 P-type trefoil, conserved site
Protein Ontology PR:000014858 sucrase-isomaltase, intestinal
References (Earliest) J:8342 James PS, et al., Evidence for a possible regulatory gene (Suc-1) controlling sucrase expression in mouse intestine. Biochem Genet. 1986 Apr;24(3-4):169-81
(Latest) J:201436 Chang I, et al., Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
All references(54)
Other
accession IDs
MGD-MRK-14410, MGI:98303

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory