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Sis Gene Detail
Summary
  • Symbol
    Sis
  • Name
    sucrase isomaltase (alpha-glucosidase)
  • Synonyms
    2010204N08Rik, Si-s, sucrase-isomaltase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917233
    NCBI Gene: 69983
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:72888557-72967863 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 32.59 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    343 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917233
protein coding gene Chr3:72888554-72967864 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027300
protein coding gene Chr3:72272014-72358813 (-)
A/J MGP_AJ_G0027262
protein coding gene Chr3:70097409-70174221 (-)
AKR/J MGP_AKRJ_G0027230
protein coding gene Chr3:71664855-71740845 (-)
BALB/cJ MGP_BALBcJ_G0027273
protein coding gene Chr3:70002954-70082050 (-)
C3H/HeJ MGP_C3HHeJ_G0027017
protein coding gene Chr3:71923198-72001264 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027719
protein coding gene Chr3:75137250-75222563 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025072
protein coding gene Chr3:66131666-66202514 (-)
CAST/EiJ MGP_CASTEiJ_G0026464
protein coding gene Chr3:71881803-71960111 (-)
CBA/J MGP_CBAJ_G0026992
protein coding gene Chr3:77442492-77539641 (-)
DBA/2J MGP_DBA2J_G0027128
protein coding gene Chr3:69577131-69655275 (-)
FVB/NJ MGP_FVBNJ_G0027096
protein coding gene Chr3:68115523-68189604 (-)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0027777
protein coding gene Chr3:71469184-71548450 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026014
protein coding gene Chr3:70628634-70711033 (-)
WSB/EiJ MGP_WSBEiJ_G0026542
protein coding gene Chr3:71663677-71746502 (-)



Homology
more
  • Human Ortholog
    SI, sucrase-isomaltase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SI, sucrase-isomaltase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 6476
    neXtProt AC: NX_P14410
    UniProt: P14410

  • Chr Location
    3q26.1; chr3:164978898-165078495 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027790 Ensembl Gene Model | MGI Sequence Detail 79307 C57BL/6J ±  kb
transcript ENSMUST00000167334 Ensembl | MGI Sequence Detail 5953 Not Applicable  
polypeptide ENSMUSP00000129116 Ensembl | MGI Sequence Detail 1818 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR011013 Galactose mutarotase-like domain superfamily
    IPR031727 Galactose mutarotase, N-terminal barrel
    IPR000322 Glycoside hydrolase family 31
    IPR025887 Glycoside hydrolase family 31, N-terminal domain
    IPR017853 Glycoside hydrolase superfamily
    IPR013780 Glycosyl hydrolase, all-beta
    IPR030458 Glycosyl hydrolases family 31, active site
    IPR030459 Glycosyl hydrolases family 31, conserved site
    IPR017957 P-type trefoil, conserved site
    IPR000519 P-type trefoil domain
Molecular
Reagents
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  • All nucleic 14
    Genomic 2
    cDNA 10
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-14410, MGI:98303
References
more
  • Summaries
    All 54
    Developmental Gene Expression 18
    Diseases 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:8342 James PS, et al., Evidence for a possible regulatory gene (Suc-1) controlling sucrase expression in mouse intestine. Biochem Genet. 1986 Apr;24(3-4):169-81
  • Latest
    J:256638 Yanai H, et al., Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity. Sci Rep. 2017 Aug 31;7(1):9891

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory