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Sis Gene Detail
Summary
  • Symbol
    Sis
  • Name
    sucrase isomaltase (alpha-glucosidase)
  • Synonyms
    2010204N08Rik, Si-s, sucrase-isomaltase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917233
    NCBI Gene: 69983
Location & Maps
more
  • Sequence Map
    Chr3:72888557-72967863 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      79307 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 32.59 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    SI, sucrase-isomaltase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SI, sucrase-isomaltase
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 6476
    neXtProt AC: NX_P14410

  • Chr Location
    3q25.2-q26.2; chr3:164978893-165078495 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SI associations

Human Disease Mouse Models
       Sucrase-Isomaltase Deficiency, Congenital; CSID   OMIM: 222900
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Sis
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035151 VEGA Gene Model | MGI Sequence Detail 79307 C57BL/6J ±  kb
transcript OTTMUST00000089508 VEGA | MGI Sequence Detail 5953 Not Applicable  
polypeptide OTTMUSP00000048927 VEGA | MGI Sequence Detail 1818 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    343 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR011013 Galactose mutarotase-like domain
    IPR031727 Galactose mutarotase, N-terminal barrel
    IPR000322 Glycoside hydrolase family 31
    IPR025887 Glycoside hydrolase family 31, N-terminal domain
    IPR017853 Glycoside hydrolase superfamily
    IPR030458 Glycosyl hydrolases family 31, active site
    IPR030459 Glycosyl hydrolases family 31, conserved site
    IPR017957 P-type trefoil, conserved site
    IPR000519 P-type trefoil domain
Molecular
Reagents
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  • All nucleic 13
    Genomic 2
    cDNA 9
    Primer pair 2

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-14410, MGI:98303
References
more
  • Summaries
    All 49
    Developmental Gene Expression 16
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:8342 James PS, et al., Evidence for a possible regulatory gene (Suc-1) controlling sucrase expression in mouse intestine. Biochem Genet. 1986 Apr;24(3-4):169-81
  • Latest
    J:212415 Kinzel B, et al., Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice. Dev Biol. 2014 Jun 15;390(2):181-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory