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Spink2
Gene Detail
Symbol

Name
ID
Spink2
serine peptidase inhibitor, Kazal type 2
MGI:1917232
Synonyms
1700007F22Rik, acrosin-trypsin inhibitor, HUSI-II
Feature Type
protein coding gene
Genetic Map
Chromosome 5
41.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:77205107-77211471 bp, - strand
From VEGA annotation of GRCm38

  6365 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134017  Vertebrate Homology Class
1 mouse; 2 rat

Protein SuperFamily: pancreatic secretory trypsin inhibitor
Gene Tree: Spink2

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(42) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trap allele exhibit reduced male fertility associated with oligozoospermia, teratozoospermia, male germ cell apoptosis, and small testis.
 
Phenotype Images(5)
Interactions
Spink2 interacts with 48 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process apoptotic process, cell differentiation, ...
Component acrosomal vesicle, cytoplasm, ...
Function peptidase inhibitor activity, serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(46) cDNA(46)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000026576 (Evidence)
Ensembl Gene ModelENSMUSG00000053030 (Evidence)
Entrez Gene69982 (Evidence)
UniGene46106
DFCITC1579396
DoTSDT.101392295, DT.94220701
NIA Mouse Gene IndexU026331
Consensus CDS ProjectCCDS39121.1
International Mouse Knockout Project StatusSpink2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026576 VEGA Gene Model | MGI Sequence Detail 6365 C57BL/6J ±  kb
transcript OTTMUST00000065750 VEGA | MGI Sequence Detail 631 Not Applicable 
polypeptide OTTMUSP00000032810 VEGA | MGI Sequence Detail 86 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
Protein Ontology PR:000015533 serine protease inhibitor Kazal-type 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:175913 Lee B, et al., Impaired spermatogenesis and fertility in mice carrying a mutation in the Spink2 gene expressed predominantly in testes. J Biol Chem. 2011 Aug 19;286(33):29108-17
All references(30)
Other
accession IDs
MGI:2141109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory