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Spink2 Gene Detail
Summary
  • Symbol
    Spink2
  • Name
    serine peptidase inhibitor, Kazal type 2
  • Synonyms
    1700007F22Rik, acrosin-trypsin inhibitor, HUSI-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917232
    NCBI Gene: 69982
Location & Maps
more
  • Sequence Map
    Chr5:77205107-77211471 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6365 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 41.53 cM
  • Mapping Data
    2 experiments
Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    2
  • Gene trapped
    42
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Spink2
  • Incidental Mutations
    APF
Mice homozygous for a gene trap allele exhibit reduced male fertility associated with oligozoospermia, teratozoospermia, male germ cell apoptosis, and small testis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026576 VEGA Gene Model | MGI Sequence Detail 6365 C57BL/6J ±  kb
transcript OTTMUST00000065750 VEGA | MGI Sequence Detail 631 Not Applicable  
polypeptide OTTMUSP00000032810 VEGA | MGI Sequence Detail 86 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    20 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015533 serine protease inhibitor Kazal-type 2
  • InterPro Domains
    IPR002350 Kazal domain
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141109
References
more
  • Summaries
    All 27
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:215026 Dietz JA, et al., Spink2 modulates apoptotic susceptibility and is a candidate gene in the Rgcs1 QTL that affects retinal ganglion cell death after optic nerve damage. PLoS One. 2014;9(4):e93564

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory