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Spink2 Gene Detail
Summary
  • Symbol
    Spink2
  • Name
    serine peptidase inhibitor, Kazal type 2
  • Synonyms
    1700007F22Rik, acrosin-trypsin inhibitor, HUSI-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917232
    NCBI Gene: 69982
  • Gene Overview
    MyGene.info: SPINK2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:77205107-77211471 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 41.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917232
protein coding gene Chr5:77205106-77216257 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029655
protein coding gene Chr5:77456042-77464742 (-)
A/J MGP_AJ_G0029623
protein coding gene Chr5:74473973-74481191 (-)
AKR/J MGP_AKRJ_G0029571
protein coding gene Chr5:76921059-76927011 (-)
BALB/cJ MGP_BALBcJ_G0029632
protein coding gene Chr5:75214834-75220662 (-)
C3H/HeJ MGP_C3HHeJ_G0029355
protein coding gene Chr5:77276056-77283968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030086
protein coding gene Chr5:80545417-80551231 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027327
protein coding gene Chr5:70198764-70204782 (-)
CAST/EiJ MGP_CASTEiJ_G0028763
protein coding gene Chr5:76502814-76508623 (-)
CBA/J MGP_CBAJ_G0029324
protein coding gene Chr5:83204822-83214934 (-)
DBA/2J MGP_DBA2J_G0029469
protein coding gene Chr5:74533709-74540137 (-)
FVB/NJ MGP_FVBNJ_G0029430
protein coding gene Chr5:73737955-73743973 (-)
LP/J MGP_LPJ_G0029556
protein coding gene Chr5:77874967-77882450 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029458
protein coding gene Chr5:86310586-86318063 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030119
protein coding gene Chr5:76466122-76472629 (-)
PWK/PhJ MGP_PWKPhJ_G0028486
protein coding gene Chr5:73552966-73559245 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028321
protein coding gene Chr5:75832549-75838110 (-)
WSB/EiJ MGP_WSBEiJ_G0028843
protein coding gene Chr5:76787894-76795439 (-)



Homology
more
  • Human Ortholog
    SPINK2, serine peptidase inhibitor, Kazal type 2
  • Vertebrate Orthologs
    3
  • Human Ortholog
    SPINK2, serine peptidase inhibitor, Kazal type 2
    Orthology source: HGNC
  • Synonyms
    HUSI-II, SPGF29
  • Links
    NCBI Gene ID: 6691
    neXtProt AC: NX_P20155
    UniProt: P20155

  • Chr Location
    4q12; chr4:56809860-56822210 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    5 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Chemically induced (other)
    2
  • Gene trapped
    42
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Spink2
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a gene trap allele exhibit reduced male fertility associated with oligozoospermia, teratozoospermia, male germ cell apoptosis, and small testis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053030 Ensembl Gene Model | MGI Sequence Detail 6365 C57BL/6J ±  kb
transcript ENSMUST00000065216 Ensembl | MGI Sequence Detail 631 Not Applicable  
polypeptide ENSMUSP00000067117 Ensembl | MGI Sequence Detail 86 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141109
References
more
  • Summaries
    All 35
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:255306 Kherraf ZE, et al., SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes. EMBO Mol Med. 2017 Aug;9(8):1132-1149

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory