About   Help   FAQ
Fars2 Gene Detail
Summary
  • Symbol
    Fars2
  • Name
    phenylalanine-tRNA synthetase 2 (mitochondrial)
  • Synonyms
    2810431B21Rik, 6720478K01Rik, Fars1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917205
    NCBI Gene: 69955
  • Gene Overview
    MyGene.info: FARS2
Location & Maps
more
  • Sequence Map
    Chr13:36117643-36537595 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      419953 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.44 cM, cytoband A5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FARS2, phenylalanyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FARS2, phenylalanyl-tRNA synthetase 2, mitochondrial
    Orthology source: HGNC, HomoloGene
  • Synonyms
    COXPD14, FARS1, HSPC320, PheRS
  • Links
    NCBI Gene ID: 10667
    neXtProt AC: NX_O95363

  • Chr Location
    6p25.1; chr6:5261018-5771583 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human FARS2 associations

Human Disease Mouse Models
       Combined Oxidative Phosphorylation Deficiency 14; COXPD14   OMIM: 614946
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    33
  • Chemically induced (other)
    1
  • Gene trapped
    30
  • Targeted
    2
  • Genomic Mutations
    1 involving Fars2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69955 NCBI Gene Model | MGI Sequence Detail 419953 C57BL/6J ±  kb
transcript NM_024274 RefSeq | MGI Sequence Detail 1896 C57BL/6  
polypeptide Q99M01 UniProt | EBI | MGI Sequence Detail 451 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3083 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007345 phenylalanine--tRNA ligase, mitochondrial
  • EC
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding
    IPR002319 Phenylalanyl-tRNA synthetase
    IPR004530 Phenylalanyl-tRNA synthetase, class IIc, mitochondrial
Molecular
Reagents
less
  • All nucleic 59
    cDNA 59

    Microarray probesets 2
Other
Accession IDs
less
MGI:1925151
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory