Fars2
Gene Detail

Symbol Name ID

Fars2 phenylalanine-tRNA synthetase 2 (mitochondrial) MGI:1917205

Synonyms

2810431B21Rik, 6720478K01Rik, Fars1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

14.44 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:36117411-36537592 bp, + strand From Ensembl annotation of GRCm38   420182 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4788  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fars2

Human homologs

Human Homolog		FARS2, phenylalanyl-tRNA synthetase 2, mitochondrial
NCBI Gene ID		10667
neXtProt AC		NX_O95363
Human Synonyms		COXPD14, dJ520B18.2, FARS1, HSPC320, PheRS
Human Chr (Location)		6p25.1; chr6:5261584-5771816 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FARS2

Alleles and phenotypes

All alleles(32) : Targeted(2) Gene trapped(30)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	phenylalanyl-tRNA aminoacylation, translation, ...
Component	cytoplasm, mitochondrion
Function	aminoacyl-tRNA ligase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (12)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) cDNA(58)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000021420 (Evidence)
Entrez Gene	69955 (Evidence)
UniGene	70690
DFCI	TC1577454, TC1595661, TC1627803
NIA Mouse Gene Index	U014728, U148575
EC	6.1.1.20
Consensus CDS Project	CCDS26453.1, CCDS26454.1
International Mouse Knockout Project Status	Fars2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021420	Ensembl Gene Model | MGI Sequence Detail	420182	C57BL/6J
transcript	ENSMUST00000021857	Ensembl | MGI Sequence Detail	2125	Not Applicable
polypeptide	ENSMUSP00000021857	Ensembl | MGI Sequence Detail	451	Not Applicable

All sequences(25) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(2751 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006195	Aminoacyl-tRNA synthetase, class II
InterPro	IPR005121	Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding
InterPro	IPR002319	Phenylalanyl-tRNA synthetase
InterPro	IPR004530	Phenylalanyl-tRNA synthetase, class IIc, mitochondrial
Protein Ontology	PR:000007345	phenylalanyl-tRNA synthetase, mitochondrial

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(33)

Other accession IDs

MGI:1925151