About   Help   FAQ
Fars2
Gene Detail
Symbol

Name
ID
Fars2
phenylalanine-tRNA synthetase 2 (mitochondrial)
MGI:1917205
Synonyms
2810431B21Rik, 6720478K01Rik, Fars1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
14.44 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:36117643-36537595 bp, + strand
From NCBI annotation of GRCm38

  419953 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4788  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FARS2
Gene Tree: Fars2

Human
homologs
FARS2, phenylalanyl-tRNA synthetase 2, mitochondrial
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10667
neXtProt AC: NX_O95363

Human Synonyms: COXPD14, dJ520B18.2, FARS1, HSPC320, PheRS

Human Chr (Location): 6p25.1; chr6:5261018-5771583 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FARS2

Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(30) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Fars2 interacts with 19 markers (Mir20a, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process phenylalanyl-tRNA aminoacylation, translation, ...
Component cytoplasm, mitochondrion
Function aminoacyl-tRNA ligase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(59)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fars2    NEW 
Molecular
reagents
All nucleic(59) cDNA(59)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000021420 (Evidence)
Entrez Gene 69955 (Evidence)
UniGene 70690
DFCI TC1577454, TC1595661, TC1627803, TC1681643
NIA Mouse Gene Index U014728, U148575
EC 6.1.1.20
Consensus CDS Project CCDS26453.1, CCDS26454.1
International Mouse Phenotyping Consortium Status Fars2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 69955 NCBI Gene Model | MGI Sequence Detail 419953 C57BL/6J ±  kb
transcript NM_024274 RefSeq | MGI Sequence Detail 1896 C57BL/6 
polypeptide Q99M01 UniProt | EBI | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(13) UniProt(3)
Polymorphisms
SNPs within 2kb(3103 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3109)
Protein-related
information
ResourceIDDescription
InterPro IPR006195 Aminoacyl-tRNA synthetase, class II
InterPro IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding
InterPro IPR002319 Phenylalanyl-tRNA synthetase
InterPro IPR004530 Phenylalanyl-tRNA synthetase, class IIc, mitochondrial
Protein Ontology PR:000007345 phenylalanine--tRNA ligase, mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(32)
Other
accession IDs
MGI:1925151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory