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Tspan18 Gene Detail
Summary
  • Symbol
    Tspan18
  • Name
    tetraspanin 18
  • Synonyms
    2610042G18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917186
    NCBI Gene: 241556
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:93032105-93164850 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 51.37 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1039 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917186
 protein coding gene Chr2:93032105-93164898 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026174
 protein coding gene Chr2:94693368-94825445 (-)
A/J MGP_AJ_G0026135
 protein coding gene Chr2:90844557-90973382 (-)
AKR/J MGP_AKRJ_G0026116
 protein coding gene Chr2:93382262-93519821 (-)
BALB/cJ MGP_BALBcJ_G0026144
 protein coding gene Chr2:91035295-91168709 (-)
C3H/HeJ MGP_C3HHeJ_G0025895
 protein coding gene Chr2:93659599-93794463 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026595
 protein coding gene Chr2:97916706-98058969 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023986
 protein coding gene Chr2:87330511-87464143 (-)
CAST/EiJ MGP_CASTEiJ_G0025360
 protein coding gene Chr2:94241653-94382296 (-)
CBA/J MGP_CBAJ_G0025873
 protein coding gene Chr2:101319738-101465773 (-)
DBA/2J MGP_DBA2J_G0026009
 protein coding gene Chr2:90453800-90585076 (-)
FVB/NJ MGP_FVBNJ_G0025972
 protein coding gene Chr2:89565868-89699644 (-)
LP/J MGP_LPJ_G0026113
 protein coding gene Chr2:94893612-95036473 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025998
 protein coding gene Chr2:104257643-104398527 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026649
 protein coding gene Chr2:93460462-93599677 (-)
PWK/PhJ MGP_PWKPhJ_G0025095
 protein coding gene Chr2:90196045-90329171 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024896
 protein coding gene Chr2:93031933-93164708 (-)
WSB/EiJ MGP_WSBEiJ_G0025427
 protein coding gene Chr2:94077045-94209478 (-)



Homology
more
  • Human Ortholog
    TSPAN18, tetraspanin 18
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TSPAN18, tetraspanin 18
  • Synonyms
    TSPAN
  • Links
    NCBI Gene ID: 90139
    neXtProt AC: NX_Q96SJ8
    UniProt: Q96SJ8

  • Chr Location
    11p11.2; chr11:44726310-44932423 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a hemostasis defect, impaired histamine-induced von Willebrand Factor (vWF) release, and decreased susceptibility to induced thrombosis in vWF-dependent thrombo-inflammatory models.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    47
  • cDNA Data
    8
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027217 Ensembl Gene Model | MGI Sequence Detail 132746 C57BL/6J ±  kb
    transcript ENSMUST00000111265 Ensembl | MGI Sequence Detail 3751 Not Applicable  
    polypeptide ENSMUSP00000106896 Ensembl | MGI Sequence Detail 248 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:3035432
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:295079 Noy PJ, et al., Tspan18 is a novel regulator of the Ca(2+) channel Orai1 and von Willebrand factor release in endothelial cells. Haematologica. 2019 Sep;104(9):1892-1905
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory