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Dnah17 Gene Detail
Summary
  • Symbol
    Dnah17
  • Name
    dynein, axonemal, heavy chain 17
  • Synonyms
    2810003K23Rik, Dnahc17, Dnahcl1, LOC382552
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917176
    NCBI Gene: 69926
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr11:118021723-118130634 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 82.96 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    338 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917176
protein coding gene Chr11:118021723-118130719 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019461
protein coding gene Chr11:122328075-122441239 (-)
A/J MGP_AJ_G0019429
protein coding gene Chr11:116899699-117010680 (-)
AKR/J MGP_AKRJ_G0019399
protein coding gene Chr11:120451506-120560851 (-)
BALB/cJ MGP_BALBcJ_G0019404
protein coding gene Chr11:117266713-117374802 (-)
C3H/HeJ MGP_C3HHeJ_G0019210
protein coding gene Chr11:120749250-120861715 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019853
protein coding gene Chr11:126066829-126186799 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017478
protein coding gene Chr11:113909987-114021454 (-)
CAST/EiJ MGP_CASTEiJ_G0018764
protein coding gene Chr11:122166576-122286539 (-)
CBA/J MGP_CBAJ_G0019181
protein coding gene Chr11:131004966-131125981 (-)
DBA/2J MGP_DBA2J_G0019293
protein coding gene Chr11:116292235-116401124 (-)
FVB/NJ MGP_FVBNJ_G0019285
protein coding gene Chr11:115923191-116038553 (-)
LP/J MGP_LPJ_G0019363
protein coding gene Chr11:122645868-122760545 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019318
protein coding gene Chr11:129971111-130085944 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019892
protein coding gene Chr11:121106655-121220563 (-)
PWK/PhJ MGP_PWKPhJ_G0018530
protein coding gene Chr11:117657970-117769404 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018322
protein coding gene Chr11:120834923-120943518 (-)
WSB/EiJ MGP_WSBEiJ_G0018816
protein coding gene Chr11:121072283-121184277 (-)



Homology
more
  • Human Ortholog
    DNAH17, dynein axonemal heavy chain 17
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DNAH17, dynein axonemal heavy chain 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNAHL1, DNEL2, SPGF39
  • Links
    NCBI Gene ID: 8632
    neXtProt AC: NX_Q9UFH2
    UniProt: Q9UFH2

  • Chr Location
    17q25.3; chr17:78423697-78577430 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DNAH17 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033987 Ensembl Gene Model | MGI Sequence Detail 108912 C57BL/6J ±  kb
    transcript ENSMUST00000106308 Ensembl | MGI Sequence Detail 14973 Not Applicable  
    polypeptide ENSMUSP00000101915 Ensembl | MGI Sequence Detail 4481 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000006561 dynein heavy chain 17, axonemal
    • InterPro Domains
      IPR026983 Dynein heavy chain
      IPR041589 Dynein heavy chain 3, AAA+ lid domain
      IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
      IPR041466 Dynein heavy chain, AAA 5 extension domain
      IPR041658 Dynein heavy chain AAA lid domain
      IPR042219 Dynein heavy chain AAA lid domain superfamily
      IPR024317 Dynein heavy chain, AAA module D4
      IPR035706 Dynein heavy chain, ATP-binding dynein motor region
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR041228 Dynein heavy chain, C-terminal domain
      IPR043160 Dynein heavy chain, C-terminal domain, barrel region
      IPR013594 Dynein heavy chain, domain-1
      IPR013602 Dynein heavy chain, domain-2
      IPR042228 Dynein heavy chain, domain 2, C-terminal
      IPR042222 Dynein heavy chain, domain 2, N-terminal
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
      IPR004273 Dynein heavy chain region D6 P-loop domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
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    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2686024
    References
    more
    • Summaries
      All 30
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:43700 Neesen J, et al., Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene. Gene. 1997 Oct 24;200(1-2):193-202
    • Latest
      J:285088 Zhang B, et al., A DNAH17 missense variant causes flagella destabilization and asthenozoospermia. J Exp Med. 2020 Feb 3;217(2)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/13/2020
    MGI 6.16
    The Jackson Laboratory