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Agk Gene Detail
Summary
  • Symbol
    Agk
  • Name
    acylglycerol kinase
  • Synonyms
    2610037M15Rik, MuLK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917173
    NCBI Gene: 69923
  • Gene Overview
    MyGene.info: AGK
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:40325172-40396762 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 18.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917173
protein coding gene Chr6:40325076-40397570 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030605
protein coding gene Chr6:38779400-38852203 (+)
A/J MGP_AJ_G0030578
protein coding gene Chr6:37070819-37143116 (+)
AKR/J MGP_AKRJ_G0030505
protein coding gene Chr6:38247522-38319806 (+)
BALB/cJ MGP_BALBcJ_G0030588
protein coding gene Chr6:37286179-37358290 (+)
C3H/HeJ MGP_C3HHeJ_G0030301
protein coding gene Chr6:38271705-38345289 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031042
protein coding gene Chr6:39743817-39819459 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028254
protein coding gene Chr6:34940254-35014259 (+)
CAST/EiJ MGP_CASTEiJ_G0029703
protein coding gene Chr6:38193240-38266832 (+)
CBA/J MGP_CBAJ_G0030279
protein coding gene Chr6:41335896-41412227 (+)
DBA/2J MGP_DBA2J_G0030423
protein coding gene Chr6:36881804-36957933 (+)
FVB/NJ MGP_FVBNJ_G0030377
protein coding gene Chr6:36668072-36700074 (+)
LP/J MGP_LPJ_G0030510
protein coding gene Chr6:38782963-38854255 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030413
protein coding gene Chr6:43578656-43579936 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031072
protein coding gene Chr6:38215363-38286693 (+)
PWK/PhJ MGP_PWKPhJ_G0029417
protein coding gene Chr6:36576806-36651361 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029253
protein coding gene Chr6:37929117-38003384 (+)
WSB/EiJ MGP_WSBEiJ_G0029779
protein coding gene Chr6:38160881-38231629 (+)



Homology
more
  • Human Ortholog
    AGK, acylglycerol kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AGK, acylglycerol kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CATC5, CTRCT38, MTDPS10, MULK
  • Links
    NCBI Gene ID: 55750
    neXtProt AC: NX_Q53H12
    UniProt: Q53H12

  • Chr Location
    7q34; chr7:141551278-141655244 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human AGK associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
T cell specific knockout reduces CD8+ T cell proliferation and antitumor immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029916 Ensembl Gene Model | MGI Sequence Detail 71591 C57BL/6J ±  kb
    transcript ENSMUST00000031977 Ensembl | MGI Sequence Detail 2531 Not Applicable  
    polypeptide ENSMUSP00000031977 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 47

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1889847
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:282052 Hu Z, et al., Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8(+) T Cells. Cell Metab. 2019 Aug 6;30(2):290-302.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    02/23/2021
    MGI 6.16
    The Jackson Laboratory