Nabp2 MGI Mouse Gene Detail - MGI:1917167 - nucleic acid binding protein 2

Symbol

Nabp2
Name

nucleic acid binding protein 2
Synonyms

2610036N15Rik, Nabp2, Obfc2b, SSB1

Feature Type

protein coding gene
IDs

MGI:1917167
NCBI Gene: 69917
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:128401394-128411487 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.55 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

104 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917167	protein coding gene	Chr10:128401394-128411492 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017864	protein coding gene	Chr10:132135107-132145169 (-)
A/J	MGP_AJ_G0017839	protein coding gene	Chr10:126827781-126838582 (-)
AKR/J	MGP_AKRJ_G0017802	protein coding gene	Chr10:130551240-130561296 (-)
BALB/cJ	MGP_BALBcJ_G0017803	protein coding gene	Chr10:127210775-127220837 (-)
C3H/HeJ	MGP_C3HHeJ_G0017626	protein coding gene	Chr10:130714677-130724767 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018258	protein coding gene	Chr10:136612549-136622604 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015936	protein coding gene	Chr10:120762328-120771674 (-)
CAST/EiJ	MGP_CASTEiJ_G0017187	protein coding gene	Chr10:131424568-131437213 (-)
CBA/J	MGP_CBAJ_G0017596	protein coding gene	Chr10:142159216-142169286 (-)
DBA/2J	MGP_DBA2J_G0017702	protein coding gene	Chr10:125889438-125902430 (-)
FVB/NJ	MGP_FVBNJ_G0017697	protein coding gene	Chr10:124818683-124829354 (-)
LP/J	MGP_LPJ_G0017776	protein coding gene	Chr10:132727702-132738544 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017725	protein coding gene	Chr10:144764753-144774876 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018298	protein coding gene	Chr10:130651269-130661660 (-)
PWK/PhJ	MGP_PWKPhJ_G0016972	protein coding gene	Chr10:126149294-126159632 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016761	protein coding gene	Chr10:129745596-129755744 (-)
WSB/EiJ	MGP_WSBEiJ_G0017246	protein coding gene	Chr10:130867094-130877147 (-)

Human Ortholog

NABP2, nucleic acid binding protein 2

Vertebrate Orthologs

7

Human Ortholog

NABP2, nucleic acid binding protein 2
Orthology source: HomoloGene, HGNC
Synonyms

hSSB1, OBFC2B, SOSS-B1, SSB1
Links

HGNC:28412

NCBI Gene ID: 79035

neXtProt AC: NX_Q9BQ15

UniProt: Q9BQ15
Chr Location

12q13.3; chr12:56222039-56229858 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11446
1 human;1 mouse;1 rat;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: NABP2
Gene Tree

Nabp2

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Phenotype Summary

77 phenotypes from 6 alleles in 6 genetic backgrounds
7 phenotypes from multigenic genotypes
11 images
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

36
Gene trapped

26
Targeted

10
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele exhibit complete perinatal lethality, fetal growth retardation, abnormal limb development, abnormal cranium morphology, small rib cage, thin and porous bones, cleft palate, oligodactyly, increased apoptosis at E12.5 and increased genomic instability.

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All GO Annotations

25
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

22
Tissues

13
cDNA Data

62
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nabp2

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Nabp2 interacts with 51 markers (Mir30a, Mir30d, Mir30e, ...) View All

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All Sequences

67
RefSeq

14
UniProt

7
CCDS

CCDS24276.1
UniGene

46614

Ensembl

ENSMUSG00000025374 (Evidence)
NCBI Gene

69917

			Length	Strain/Species	Flank
genomic	69917	NCBI Gene Model \| MGI Sequence Detail	10094	C57BL/6J	± kb
transcript	NM_001358972	RefSeq \| MGI Sequence Detail	1146	C57BL/6
polypeptide	Q8R2Y9	UniProt \| EBI \| MGI Sequence Detail	212	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000011584 SOSS complex subunit B1

(term hierarchy)
InterPro Domains

IPR012340 Nucleic acid-binding, OB-fold

IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type

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All nucleic 63

cDNA 62

Primer pair 1

Microarray probesets 2

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 16
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:277169 Pfeifer M, et al., SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors. J Immunol. 2019 Jun 15;202(12):3423-3433

TSS for Nabp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99871	Chr10:128410532-128410565 (-)	938 bp
Tssr99870	Chr10:128409766-128409862 (-)	1,673 bp
Tssr99869	Chr10:128409319-128409374 (-)	2,140 bp
Tssr99868	Chr10:128409178-128409191 (-)	2,302 bp
Tssr99867	Chr10:128409146-128409176 (-)	2,326 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/01/2019 MGI 6.14