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Slc25a32 Gene Detail
Summary
  • Symbol
    Slc25a32
  • Name
    solute carrier family 25, member 32
  • Synonyms
    2610043O12Rik, Mftc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917156
    NCBI Gene: 69906
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:38954626-38976111 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    325 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917156
 protein coding gene Chr15:38954625-38976213 (-)
129S1/SvImJ ENSMUSG00200026717
 protein coding gene Chr15:35954856-35976326 (-)
A/J ENSMUSG00195033297
 protein coding gene Chr15:35890620-35912115 (-)
AKR/J ENSMUSG00220026620
 protein coding gene Chr15:35804667-35826163 (-)
BALB/cJ ENSMUSG00180031362
 protein coding gene Chr15:35862120-35883611 (-)
C3H/HeJ ENSMUSG00175026425
 protein coding gene Chr15:36056393-36077804 (-)
C57BL/6NJ ENSMUSG00215018488
 protein coding gene Chr15:35868582-35890071 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019756
 protein coding gene Chr15:33818260-33836103 (-)
CAST/EiJ ENSTCUG00005010419
 protein coding gene Chr15:35883158-35904601 (-)
CBA/J ENSMUSG00210017918
 protein coding gene Chr15:35984365-36005858 (-)
DBA/2J ENSMUSG00185034076
 protein coding gene Chr15:35965215-35986704 (-)
FVB/NJ ENSMUSG00205024834
 protein coding gene Chr15:35854999-35876493 (-)
JF1/MsJ ENSUMUG00000021697
 protein coding gene Chr15:35853152-35874642 (-)
LP/J ENSMUSG00230011996
 protein coding gene Chr15:39335883-39357441 (-)
NOD/ShiLtJ ENSMUSG00190024552
 protein coding gene Chr15:35921142-35942566 (-)
NZO/HlLtJ ENSMUSG00225030636
 protein coding gene Chr15:39643480-39664977 (-)
PWK/PhJ ENSLUMG00010029267
 protein coding gene Chr15:36003218-36024707 (-)
SPRET/EiJ ENSMSPG00010012189
 protein coding gene Chr15:36662884-36679558 (-)
WSB/EiJ ENSIUOG00005030251
 protein coding gene Chr15:35970380-35991760 (-)



Homology
more
  • Human Ortholog
    SLC25A32, solute carrier family 25 member 32
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A32, solute carrier family 25 member 32
  • Synonyms
    GLYB, MFT, MFTC, RREI
  • Links
    NCBI Gene ID: 81034
    UniProt: Q9H2D1

  • Chr Location
    8q22.3; chr8:103398635-103415189 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality and fully penetrant cranial neural tube defects that can be partially rescued by maternal calcium formate supplementation. Homozygous KO also results in abnormal folate, amino acid and carnitine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    7
  • cDNA Data
    26
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022299 Ensembl Gene Model | MGI Sequence Detail 21486 C57BL/6J ±  kb
    transcript ENSMUST00000022908 Ensembl | MGI Sequence Detail 5905 Not Applicable  
    polypeptide ENSMUSP00000022908 Ensembl | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 26
      Primer pair 4
      Antibodies 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 12
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:338257 Peng MZ, et al., Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. Cell Mol Life Sci. 2022 Jun 21;79(7):375
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory