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Slc25a32 Gene Detail
Summary
  • Symbol
    Slc25a32
  • Name
    solute carrier family 25, member 32
  • Synonyms
    2610043O12Rik, Mftc
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917156
    NCBI Gene: 69906
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:38954626-38976111 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.39 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    325 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917156
 protein coding gene Chr15:38954625-38976213 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021813
 protein coding gene Chr15:37513818-37534071 (-)
A/J MGP_AJ_G0021773
 protein coding gene Chr15:36065698-36084108 (-)
AKR/J MGP_AKRJ_G0021754
 protein coding gene Chr15:37142509-37160965 (-)
BALB/cJ MGP_BALBcJ_G0021780
 protein coding gene Chr15:36101252-36119947 (-)
C3H/HeJ MGP_C3HHeJ_G0021554
 protein coding gene Chr15:37072269-37090701 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022219
 protein coding gene Chr15:38952981-38975334 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019756
 protein coding gene Chr15:33818260-33836103 (-)
CAST/EiJ MGP_CASTEiJ_G0021071
 protein coding gene Chr15:37511061-37530450 (-)
CBA/J MGP_CBAJ_G0021523
 protein coding gene Chr15:40313671-40332125 (-)
DBA/2J MGP_DBA2J_G0021647
 protein coding gene Chr15:35893885-35912449 (-)
FVB/NJ MGP_FVBNJ_G0021625
 protein coding gene Chr15:35300802-35319244 (-)
LP/J MGP_LPJ_G0021717
 protein coding gene Chr15:37382593-37402371 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021649
 protein coding gene Chr15:43186995-43205425 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022242
 protein coding gene Chr15:37270887-37289578 (-)
PWK/PhJ MGP_PWKPhJ_G0020816
 protein coding gene Chr15:35954021-35973159 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020653
 protein coding gene Chr15:36964064-36982509 (-)
WSB/EiJ MGP_WSBEiJ_G0021126
 protein coding gene Chr15:37212457-37231689 (-)



Homology
more
  • Human Ortholog
    SLC25A32, solute carrier family 25 member 32
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A32, solute carrier family 25 member 32
  • Synonyms
    GLYB, MFT, MFTC, RREI
  • Links
    NCBI Gene ID: 81034
    neXtProt AC: NX_Q9H2D1
    UniProt: Q9H2D1

  • Chr Location
    8q22.3; chr8:103398635-103415189 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality and fully penetrant cranial neural tube defects that can be partially rescued by maternal calcium formate supplementation. Homozygous KO also results in abnormal folate, amino acid and carnitine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    7
  • cDNA Data
    26
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022299 Ensembl Gene Model | MGI Sequence Detail 21486 C57BL/6J ±  kb
    transcript ENSMUST00000022908 Ensembl | MGI Sequence Detail 5905 Not Applicable  
    polypeptide ENSMUSP00000022908 Ensembl | MGI Sequence Detail 316 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 26
      Primer pair 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:338257 Peng MZ, et al., Mitochondrial FAD shortage in SLC25A32 deficiency affects folate-mediated one-carbon metabolism. Cell Mol Life Sci. 2022 Jun 21;79(7):375
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory