About   Help   FAQ
Ppie Gene Detail
Summary
  • Symbol
    Ppie
  • Name
    peptidylprolyl isomerase E (cyclophilin E)
  • Synonyms
    2010010D16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917118
    NCBI Gene: 56031
  • Gene Overview
    MyGene.info: PPIE
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:123127115-123139951 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917118
protein coding gene Chr4:123127114-123140001 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028735
protein coding gene Chr4:124549059-124561689 (-)
A/J MGP_AJ_G0028694
protein coding gene Chr4:119686065-119699456 (-)
AKR/J MGP_AKRJ_G0028647
protein coding gene Chr4:122916291-122931785 (-)
BALB/cJ MGP_BALBcJ_G0028716
protein coding gene Chr4:120268329-120281120 (-)
C3H/HeJ MGP_C3HHeJ_G0028432
protein coding gene Chr4:123031732-123044523 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029158
protein coding gene Chr4:129365222-129377929 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026431
protein coding gene Chr4:112907546-112921997 (-)
CAST/EiJ MGP_CASTEiJ_G0027863
protein coding gene Chr4:121045530-121059636 (-)
CBA/J MGP_CBAJ_G0028397
protein coding gene Chr4:132650371-132664174 (-)
DBA/2J MGP_DBA2J_G0028546
protein coding gene Chr4:120191693-120204484 (-)
FVB/NJ MGP_FVBNJ_G0028513
protein coding gene Chr4:118810280-118822918 (-)
LP/J MGP_LPJ_G0028647
protein coding gene Chr4:124828321-124841091 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028539
protein coding gene Chr4:137592506-137606413 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029196
protein coding gene Chr4:123298479-123311352 (-)
PWK/PhJ MGP_PWKPhJ_G0027585
protein coding gene Chr4:116582776-116596047 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027411
protein coding gene Chr4:119103753-119117630 (-)
WSB/EiJ MGP_WSBEiJ_G0027943
protein coding gene Chr4:123375895-123388659 (-)



Homology
more
  • Human Ortholog
    PPIE, peptidylprolyl isomerase E
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPIE, peptidylprolyl isomerase E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYP33, CYP-33
  • Links
    NCBI Gene ID: 10450
    neXtProt AC: NX_Q9UNP9
    UniProt: Q9UNP9

  • Chr Location
    1p34.2; chr1:39738845-39765698 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Ppie
  • Incidental Mutations
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028651 Ensembl Gene Model | MGI Sequence Detail 12837 C57BL/6J ±  kb
transcript ENSMUST00000030404 Ensembl | MGI Sequence Detail 1188 Not Applicable  
polypeptide ENSMUSP00000030404 Ensembl | MGI Sequence Detail 301 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013079 peptidyl-prolyl cis-trans isomerase E
  • EC
  • InterPro Domains
    IPR029000 Cyclophilin-like domain superfamily
    IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR016304 Peptidyl-prolyl cis-trans isomerase E
    IPR034168 Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 57
    Genomic 2
    cDNA 54
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory