A1cf
Gene Detail

Symbol Name ID

A1cf APOBEC1 complementation factor MGI:1917115

Synonyms

1810073H04Rik, ACF, apobec-1 complementation factor

Feature Type

protein coding gene

Genetic Map

Chromosome 19

26.58 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:31868761-31949406 bp, + strand From NCBI annotation of GRCm38   80646 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:16363  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: A1cf

Human homologs

Human Homolog		A1CF, APOBEC1 complementation factor
NCBI Gene ID		29974
neXtProt AC		NX_Q9NQ94
Human Synonyms		ACF, ACF64, ACF65, APOBEC1CF, ASP
Human Chr (Location)		10q11.23; chr10:52559169-52645435 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Embryos homozygous for a targeted deletion of this gene are detectable only until the blastocyst stage (E3.5) and isolated mutant blastocysts fail to proliferate in vitro.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cytidine to uridine editing, mRNA modification, ...
Component	apolipoprotein B mRNA editing enzyme complex, cytoplasm, ...
Function	cytosine deaminase activity, mRNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (22)    Tissues (22)    Images (3)
Theiler Stages: 21, 28

Assay Type	Results
RNA in situ	20
RT-PCR	2

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000052595 (Evidence)
Entrez Gene	69865 (Evidence)
UniGene	87538
DFCI	TC1587359, TC1596839, TC1666809
DoTS	DT.110857339, DT.110857340, DT.40167138, DT.55232998
NIA Mouse Gene Index	U019367
Consensus CDS Project	CCDS37959.1
International Mouse Knockout Project Status	A1cf

Sequences

Length	Strain/Species
genomic	69865	NCBI Gene Model | MGI Sequence Detail	80646	C57BL/6J
transcript	NM_001081074	RefSeq | MGI Sequence Detail	3828	Not Specified
polypeptide	Q5YD48	UniProt | EBI | MGI Sequence Detail	595	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(129 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR014720	Double-stranded RNA-binding-like
InterPro	IPR006535	HnRNP R/Q splicing factor
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
Protein Ontology	PR:000003512	APOBEC1 complementation factor

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)