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A1cf Gene Detail
Summary
  • Symbol
    A1cf
  • Name
    APOBEC1 complementation factor
  • Synonyms
    1810073H04Rik, ACF, apobec-1 complementation factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917115
    NCBI Gene: 69865
  • Gene Overview
    MyGene.info: A1CF
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:31868764-31948573 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      79810 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 26.58 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    A1CF, APOBEC1 complementation factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    A1CF, APOBEC1 complementation factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACF, ACF64, ACF65, APOBEC1CF, ASP
  • Links
    NCBI Gene ID: 29974
    neXtProt AC: NX_Q9NQ94
    UniProt: Q9NQ94

  • Chr Location
    10q11.23; chr10:50799409-50885681 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 16363
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: A1CF
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    119 phenotypes from multigenic genotypes
    4 images
    253 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a targeted deletion of this gene are detectable only until the blastocyst stage (E3.5) and isolated mutant blastocysts fail to proliferate in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052595 Ensembl Gene Model | MGI Sequence Detail 79810 C57BL/6J ±  kb
    transcript ENSMUST00000075838 Ensembl | MGI Sequence Detail 2989 Not Applicable  
    polypeptide ENSMUSP00000075235 Ensembl | MGI Sequence Detail 595 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      169 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR034538 ACF, RNA recognition motif 1
      IPR034539 ACF, RNA recognition motif 3
      IPR033111 APOBEC1 complementation factor
      IPR006535 HnRNP R/Q splicing factor
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:3050446
    References
    more
    • Summaries
      All 281
      Developmental Gene Expression 2
      Diseases 8
      Gene Ontology 7
      Phenotypes 253
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:263830 Roe ND, et al., The Role of Diacylglycerol Acyltransferase (DGAT) 1 and 2 in Cardiac Metabolism and Function. Sci Rep. 2018 Mar 21;8(1):4983

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory