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A1cf Gene Detail
Summary
  • Symbol
    A1cf
  • Name
    APOBEC1 complementation factor
  • Synonyms
    1810073H04Rik, ACF, alphaMHC-Cre-Mer-Cre, alpha-MHC-MerCreMer, apobec-1 complementation factor, MCM, mer, MerCreMer, Tg(Myh6-cre/Esr1)1Jmk, Tg(Myh6-cre/Esr1*)1Jmk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917115
    NCBI Gene: 69865
  • Gene Overview
    MyGene.info: A1CF
Location & Maps
more
  • Sequence Map
    Chr19:31868761-31949406 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80646 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 26.58 cM, cytoband C3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    A1CF, APOBEC1 complementation factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    A1CF, APOBEC1 complementation factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACF, ACF64, ACF65, APOBEC1CF, ASP
  • Links
    NCBI Gene ID: 29974
    neXtProt AC: NX_Q9NQ94

  • Chr Location
    10q11.23; chr10:50799409-50885675 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 16363
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: A1CF
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    94 phenotypes from multigenic genotypes
    2 images
    177 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Embryos homozygous for a targeted deletion of this gene are detectable only until the blastocyst stage (E3.5) and isolated mutant blastocysts fail to proliferate in vitro.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052595 Ensembl Gene Model | MGI Sequence Detail 80646 C57BL/6J ±  kb
transcript ENSMUST00000075838 Ensembl | MGI Sequence Detail 3828 Not Applicable  
polypeptide ENSMUSP00000075235 Ensembl | MGI Sequence Detail 595 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    169 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003512 APOBEC1 complementation factor
  • InterPro Domains
    IPR033111 APOBEC1 complementation factor
    IPR014720 Double-stranded RNA-binding domain
    IPR006535 HnRNP R/Q splicing factor
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 14
    cDNA 13
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:3050446
References
more
  • Summaries
    All 203
    Developmental Gene Expression 2
    Diseases 3
    Gene Ontology 7
    Phenotypes 177
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231727 Harkins S, et al., Chromosomal mapping of the alphaMHC-MerCreMer transgene in mice reveals a large genomic deletion. Transgenic Res. 2016 May 10;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory