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Wnk4 Gene Detail
Summary
  • Symbol
    Wnk4
  • Name
    WNK lysine deficient protein kinase 4
  • Synonyms
    2010002J11Rik, Prkwnk4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917097
    NCBI Gene: 69847
  • Gene Overview
    MyGene.info: WNK4
Location & Maps
more
  • Sequence Map
    Chr11:101260567-101277409 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16843 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    WNK4, WNK lysine deficient protein kinase 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    WNK4, WNK lysine deficient protein kinase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PHA2B, PRKWNK4
  • Links
    NCBI Gene ID: 65266
    neXtProt AC: NX_Q96J92

  • Chr Location
    17q21.2; chr17:42779673-42797066 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Wnk4 mouse models; 1 with human WNK4 associations

Human Disease Mouse Models
       Pseudohypoaldosteronism, Type IIB; PHA2B   OMIM: 614491 View 1 model
       Gitelman Syndrome; GTLMNS   OMIM: 263800 View 1 model
Pseudohypoaldosteronism, Type IIA; PHA2A   OMIM: 145260 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 5 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    5
  • Transgenic
    3
  • Genomic Mutations
    1 involving Wnk4
  • Incidental Mutations
Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002761 VEGA Gene Model | MGI Sequence Detail 16843 C57BL/6J ±  kb
transcript OTTMUST00000005511 VEGA | MGI Sequence Detail 4117 Not Applicable  
polypeptide OTTMUSP00000002621 VEGA | MGI Sequence Detail 1222 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    85 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000017434 serine/threonine-protein kinase WNK4
  • EC
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Molecular
Reagents
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  • All nucleic 24
    cDNA 24

    Microarray probesets 3
References
more
  • Summaries
    All 59
    Developmental Gene Expression 4
    Diseases 5
    Gene Ontology 12
    Phenotypes 21
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:217619 McCormick JA, et al., Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3. J Clin Invest. 2014 Nov;124(11):4723-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory