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Wnk4
Gene Detail
Symbol

Name
ID
Wnk4
WNK lysine deficient protein kinase 4
MGI:1917097
Synonyms
2010002J11Rik, Prkwnk4
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:101260567-101277409 bp, + strand
From VEGA annotation of GRCm38

  16843 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13020  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: WNK4
Gene Tree: Wnk4

Human
homologs
WNK4, WNK lysine deficient protein kinase 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 65266
neXtProt AC: NX_Q96J92

Human Synonyms: PHA2B, PRKWNK4

Human Chr (Location): 17q21.2; chr17:42779673-42797066 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human WNK4

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(5) Transgenic(1)
Genomic Mutations involving Wnk4 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion.
 
Human Diseases Modeled in Mice Using Wnk4 (3)    Mutations Annotated to Human Diseases (3)   
Interactions
Wnk4 interacts with 215 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular chloride ion homeostasis, chloride transport, ...
Component bicellular tight junction, cell, ...
Function ATP binding, chloride channel inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (102)    Tissues (44)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 102
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wnk4    NEW 
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002761 (Evidence)
Ensembl Gene Model ENSMUSG00000035112 (Evidence)
Entrez Gene 69847 (Evidence)
UniGene 23656
DFCI TC1581970
NIA Mouse Gene Index U013361
EC 2.7.11.1
Consensus CDS Project CCDS25459.1
International Mouse Phenotyping Consortium Status Wnk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002761 VEGA Gene Model | MGI Sequence Detail 16843 C57BL/6J ±  kb
transcript OTTMUST00000005511 VEGA | MGI Sequence Detail 4117 Not Applicable 
polypeptide OTTMUSP00000002621 VEGA | MGI Sequence Detail 1222 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(14) UniProt(8)
Polymorphisms
SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology PR:000017434 serine/threonine-protein kinase WNK4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:217619 McCormick JA, et al., Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3. J Clin Invest. 2014 Nov;124(11):4723-36
All references(59)
Disease annotation references (5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory