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Wnk4
Gene Detail
 Symbol
Name
ID
Wnk4
WNK lysine deficient protein kinase 4
MGI:1917097
Synonyms 2010002J11Rik, Prkwnk4
Feature Type protein coding gene
Genetic Map
Chromosome 11
64.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:101260567-101277409 bp, + strand
From VEGA annotation of GRCm38

  16843 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13020  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Wnk4

Human
homologs
Human Homolog WNK4, WNK lysine deficient protein kinase 4
NCBI Gene ID 65266
neXtProt AC  NX_Q96J92
Human Synonyms  PHA2B, PRKWNK4
Human Chr (Location)  17q21-q22; chr17:42780614-42797066 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human WNK4
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion.
 
Human Diseases Modeled Using Mouse Wnk4 (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Wnk4 interacts with 216 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process cellular chloride ion homeostasis, chloride transport, ...
Component cell, cell junction, ...
Function ATP binding, chloride channel inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (102)    Tissues (44)    Images (22)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 102
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002761 (Evidence)
Ensembl Gene ModelENSMUSG00000035112 (Evidence)
Entrez Gene69847 (Evidence)
UniGene23656
DFCITC1581970
NIA Mouse Gene IndexU013361
EC2.7.11.1
Consensus CDS ProjectCCDS25459.1
International Mouse Knockout Project StatusWnk4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002761 VEGA Gene Model | MGI Sequence Detail 16843 C57BL/6J ±  kb
transcript OTTMUST00000005511 VEGA | MGI Sequence Detail 4117 Not Applicable 
polypeptide OTTMUSP00000002621 VEGA | MGI Sequence Detail 1222 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(14) UniProt(8)
Polymorphisms SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology PR:000017434 serine/threonine-protein kinase WNK4
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211079 Castaneda-Bueno M, et al., Modulation of NCC activity by low and high K+ intake: insights into the signaling pathways involved. Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1507-19
All references(58)
Disease annotation references (4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory