Wnk4
Gene Detail

Symbol Name ID

Wnk4 WNK lysine deficient protein kinase 4 MGI:1917097

Synonyms

2010002J11Rik, Prkwnk4

Feature Type

protein coding gene

Genetic Map

Chromosome 11

64.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:101260567-101277409 bp, + strand From VEGA annotation of GRCm38   16843 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13020  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Gene Tree: Wnk4

Human homologs

Human Homolog		WNK4, WNK lysine deficient protein kinase 4
NCBI Gene ID		65266
neXtProt AC		NX_Q96J92
Human Synonyms		PHA2B, PRKWNK4
Human Chr (Location)		17q21-q22; chr17:40932649-40949084 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a null allele display increased Na+, K+ and Cl- urinary excretion, alkalosis and decreased plasma Cl-, K+, Mg2+ and renin levels. Mice homozygous for a point mutation exhibit acidosis, hypertension, increased circulating potassium levels and decreased potassium excretion.

 
Human Diseases Modeled Using Mouse Wnk4 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cellular chloride ion homeostasis, chloride transport, ...
Component	cell junction, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (72)    Tissues (14)    Images (20)
Theiler Stages: 23

Assay Type	Results
RNA in situ	72

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(24)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002761 (Evidence)
Ensembl Gene Model	ENSMUSG00000035112 (Evidence)
Entrez Gene	69847 (Evidence)
UniGene	23656
DFCI	TC1581970
NIA Mouse Gene Index	U013361
EC	2.7.11.1
Consensus CDS Project	CCDS25459.1
International Mouse Knockout Project Status	Wnk4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002761	VEGA Gene Model | MGI Sequence Detail	16843	C57BL/6J
transcript	OTTMUST00000005511	VEGA | MGI Sequence Detail	4117	Not Applicable
polypeptide	OTTMUSP00000002621	VEGA | MGI Sequence Detail	1222	Not Applicable

All sequences(48) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR024678	Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology	PR:000017434	serine/threonine-protein kinase WNK4

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187157 Hossain Khan MZ, et al., Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination. Biochem Biophys Res Commun. 2012 Aug 24;425(2):456-61
All references(48)