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Pcgf1 Gene Detail
Summary
  • Symbol
    Pcgf1
  • Name
    polycomb group ring finger 1
  • Synonyms
    2010002K04Rik, Nspc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917087
    NCBI Gene: 69837
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83054850-83057836 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917087
 protein coding gene Chr6:83047573-83057836 (+)
129S1/SvImJ ENSMUSGG00200054736
 protein coding gene Chr6:80025498-80027777 (+)
129S1/SvImJ ENSMUSG00200010198
 protein coding gene Chr6:80024783-80025377 (+)
A/J ENSMUSGG00195055188
 protein coding gene Chr6:79702248-79704527 (+)
A/J ENSMUSG00195011722
 protein coding gene Chr6:79701540-79702127 (+)
AKR/J ENSMUSGG00220054648
 protein coding gene Chr6:78645688-78647961 (+)
AKR/J ENSMUSG00220001869
 protein coding gene Chr6:78644980-78645567 (+)
BALB/cJ ENSMUSGG00180055366
 protein coding gene Chr6:80078252-80080531 (+)
BALB/cJ ENSMUSG00180009141
 protein coding gene Chr6:80077544-80078131 (+)
C3H/HeJ ENSMUSGG00175054834
 protein coding gene Chr6:97330095-97331834 (-)
C3H/HeJ ENSMUSG00175032884
 protein coding gene Chr6:97331955-97332549 (-)
C57BL/6NJ ENSMUSG00215008658
 protein coding gene Chr6:80074975-80075569 (+)
C57BL/6NJ ENSMUSGG00215055533
 protein coding gene Chr6:80075690-80077969 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028540
 protein coding gene Chr6:79227033-79230183 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055007
 protein coding gene Chr6:79894084-79896363 (+)
CBA/J ENSMUSG00210010427
 protein coding gene Chr6:79893369-79893963 (+)
DBA/2J ENSMUSGG00185057781
 protein coding gene Chr6:80441122-80443401 (+)
DBA/2J ENSMUSG00185000875
 protein coding gene Chr6:80440407-80441001 (+)
FVB/NJ ENSMUSGG00205054598
 protein coding gene Chr6:79119950-79122229 (+)
FVB/NJ ENSMUSG00205017393
 protein coding gene Chr6:79119242-79119829 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055353
 protein coding gene Chr6:81582749-81585028 (+)
LP/J ENSMUSG00230048310
 protein coding gene Chr6:81582034-81582628 (+)
NOD/ShiLtJ ENSMUSG00190001596
 protein coding gene Chr6:79522407-79522994 (+)
NOD/ShiLtJ ENSMUSGG00190054887
 protein coding gene Chr6:79523115-79525394 (+)
NZO/HlLtJ ENSMUSGG00225055558
 protein coding gene Chr6:83490871-83493150 (+)
NZO/HlLtJ ENSMUSG00225016038
 protein coding gene Chr6:83490156-83490750 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010036123
 protein coding gene Chr6:80998326-81000838 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PCGF1, polycomb group ring finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCGF1, polycomb group ring finger 1
  • Synonyms
    2010002K04Rik, NSPC1, RNF3A-2, RNF68
  • Links
    NCBI Gene ID: 84759
    UniProt: Q9BSM1

  • Chr Location
    2p13.1; chr2:74505041-74508361 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display embryonic lethality with impaired heart looping, abnormal embryo turning and abnormal neural tube closure. Mice with loss of expression in the enteric nervous system show reduced postnatal growth and survival.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    113
  • cDNA Data
    32
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069678 Ensembl Gene Model | MGI Sequence Detail 2987 C57BL/6J ±  kb
    transcript ENSMUST00000165164 Ensembl | MGI Sequence Detail 918 Not Applicable  
    polypeptide ENSMUSP00000130614 Ensembl | MGI Sequence Detail 259 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 32
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141577
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 11
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory