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Pla2g12b
Gene Detail
 Symbol
Name
ID
Pla2g12b
phospholipase A2, group XIIB
MGI:1917086
Synonyms 2010002E04Rik, hlb218, Pla2g13
Feature Type protein coding gene
Genetic Map
Chromosome 10
29.54 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:59403660-59421976 bp, + strand
From VEGA annotation of GRCm38

  18317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11356  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pla2g12b

Human
homologs
Human Homolog PLA2G12B, phospholipase A2, group XIIB
NCBI Gene ID 84647
neXtProt AC  NX_Q9BX93
Human Synonyms  GXIIB, GXIIIsPLA2, PLA2G13
Human Chr (Location)  10q22.1; chr10:72934696-72954832 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced mutation exhibit a reduction in serum total and HDL cholesterol levels, decreased serum triglyceride levels, and hepatic steatosis.
 
Phenotype Images(1)
Interactions
Pla2g12b interacts with 53 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cholesterol homeostasis, lipid catabolic process, ...
Component extracellular region
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (115)    Tissues (96)    Images (22)
Theiler Stages: 13, 22, 23
Assay TypeResults
RNA in situ 115
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000027944 (Evidence)
Ensembl Gene ModelENSMUSG00000009646 (Evidence)
Entrez Gene69836 (Evidence)
UniGene30268
DFCITC1585173
DoTSDT.487096
NIA Mouse Gene IndexU011549
EC3.1.1.4
Consensus CDS ProjectCCDS23864.1
International Mouse Knockout Project StatusPla2g12b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027944 VEGA Gene Model | MGI Sequence Detail 18317 C57BL/6J ±  kb
transcript OTTMUST00000069223 VEGA | MGI Sequence Detail 1091 Not Applicable 
polypeptide OTTMUSP00000035125 VEGA | MGI Sequence Detail 195 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(95 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016090 Phospholipase A2 domain
InterPro IPR010711 Phospholipase A2, group XII secretory
Protein Ontology PR:000012797 group XIIB secretory phospholipase A2-like protein
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:187708 Aljakna A, et al., Pla2g12b and Hpn Are Genes Identified by Mouse ENU Mutagenesis That Affect HDL Cholesterol. PLoS One. 2012;7(8):e43139
All references(36)
Other
accession IDs
MGI:2678708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory