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Mzb1 Gene Detail
Summary
  • Symbol
    Mzb1
  • Name
    marginal zone B and B1 cell-specific protein 1
  • Synonyms
    2010001M09Rik, pERp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917066
    NCBI Gene: 69816
  • Gene Overview
    MyGene.info: MZB1
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35647266-35649367 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917066
protein coding gene Chr18:35647265-35649997 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024264
protein coding gene Chr18:33967636-33969737 (-)
A/J MGP_AJ_G0024230
protein coding gene Chr18:32800571-32802672 (-)
AKR/J MGP_AKRJ_G0024198
protein coding gene Chr18:33723845-33725946 (-)
BALB/cJ MGP_BALBcJ_G0024230
protein coding gene Chr18:32845255-32847356 (-)
C3H/HeJ MGP_C3HHeJ_G0023997
protein coding gene Chr18:33750292-33752396 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024671
protein coding gene Chr18:35188989-35191090 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022111
protein coding gene Chr18:32904876-32906979 (-)
CAST/EiJ MGP_CASTEiJ_G0023472
protein coding gene Chr18:33737441-33739525 (-)
CBA/J MGP_CBAJ_G0023965
protein coding gene Chr18:36200388-36202489 (-)
DBA/2J MGP_DBA2J_G0024097
protein coding gene Chr18:32432512-32434613 (-)
FVB/NJ MGP_FVBNJ_G0024064
protein coding gene Chr18:32118632-32120733 (-)
LP/J MGP_LPJ_G0024179
protein coding gene Chr18:34022734-34024835 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024092
protein coding gene Chr18:37437955-37440059 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024720
protein coding gene Chr18:33561681-33563782 (-)
PWK/PhJ MGP_PWKPhJ_G0023216
protein coding gene Chr18:32656086-32658179 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023023
protein coding gene Chr18:33825045-33827159 (-)
WSB/EiJ MGP_WSBEiJ_G0023535
protein coding gene Chr18:33482182-33484283 (-)



Homology
more
  • Human Ortholog
    MZB1, marginal zone B and B1 cell specific protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MZB1, marginal zone B and B1 cell specific protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEDA-7, PACAP, pERp1
  • Links
    NCBI Gene ID: 51237
    neXtProt AC: NX_Q8WU39
    UniProt: Q8WU39

  • Chr Location
    5q31.2; chr5:139387568-139389916 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024353 Ensembl Gene Model | MGI Sequence Detail 2102 C57BL/6J ±  kb
transcript ENSMUST00000025211 Ensembl | MGI Sequence Detail 905 Not Applicable  
polypeptide ENSMUSP00000025211 Ensembl | MGI Sequence Detail 188 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 3
Other
Accession IDs
less
MGI:2147333
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:211639 Rosenbaum M, et al., MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress. Genes Dev. 2014 Jun 1;28(11):1165-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory